medorex Axial stirring system Energy-saving stirring bioreactors Ideal for sensitive cell cultures medorex has optimised the axial stirring principle since 1986 for medicine, biotechnology, research, food and pharmaceutical industry. The special advantages of medorex axial systems are appreciated and used by many users also internationally. meanwhile. It is offered from medorex as a standard system with the option to equip the available stirring wave by user wish also with other stirring tools. Advantages of the axial system in edited version: • Optimum control ability, quick corrections • Ideally, e.g., for temperature profiles • A gentle, careful and homogeneous mixing of the cell culture • Extensive avoidance of the shear-stress which can damage the cells • Low foam development • High oxygen use • Impulse-energy-saving up to 60% • prevent of ground depositions • drillings in the leading pipe with optimised diameter allow the use of the equipment also with different filling heights The driving power in an Axially stirring reactor is available completely to the biological activities of the cells. The axial flow works powersaving with the help of the leading pipe and the stirrer. The free falling vortex falls back in the centre of the vessel and caused a homogeneous and optimal mixing of the medium without loss of energy. The addition of anti-foam reagents can be reduced by constant resumption of the foam. The optimal CO2 emission avoids a reduction of the oxygen admission. The constant resumption of the foam can reduce the use of anti-foam reagents. By the leading pipe generated axial stirring guidance in combination with the axially arranged heat exchangers from steel, improve the warmth assignment. They guarantee quick temperature corrections with high exactness and are ideal for generating of temperature profiles. The Post-heating and the temperature sluggishness which are caused through the double coat vessel from thick Glass arise not. medorex e.K. • Industriestrasse 2 37176 Noerten-Hardenberg • Germany Phone +49 (0)5503-8086-62 • Fax -32 Owner Dr. S. Mohazzeb email: [email protected] http://www.medorex.com Kreis-Sparkasse Northeim Kto-Nr. 11825 • BLZ 262 500 01

In contrast to the medorex axial system comes with the conventional sheet stir system to a rotation circular movement of the substrate with a concurrent deceleration of mixing. The results are: loss of energy, superfluously high impulse use, unwanted high shear stress and foam development and under unfavourable circumstances rotation stratifications and ground depositions. The Bioreactor Medorex Bio-Reactors are made of a vessel of Duran-Glas and a temperature stable and complete acid and alkali resistible Lid of PEEK. They have up to 16 ports for Sensors, Electrodes and Probes depending to their...

Control Unit FCU 05 The Control-Unit FCU 05 is the Brain of the Bioreactor. In a small 19“cabinet there are all measurement amplifiers for the Sensors and additional analogue and binary in- and outputs for the complete control of the reactor. Sensors and additional in- and output signals are connected with encoded Plugs for safety contact. The Signals are converted in Standard values (0-10V, 24V) and transferred by a serial field bus-system. By using this serial field bus-system is it very easy to add several additional parameters like Redox, Conductivity e.g. The Control-Unit FCU 05 is connected...

Process Control Software WinErs The complete supervising, controlling, documentations and data storage are done by the PC or Laptop with the Control Software WinErs which works with Windows 2000/XP. All measured data are displayed numerical and graphical in intuitive and easy useable Process pictures. There is no need for reading boring manuals or long training on cryptic commands! All measured data are collected and stored on Hard Disk and can be archivated, and exported to other programs for editing and visualisation like Excel, MathLab e.g. also data from former experiments can be evaluated...

WinErs works as a Soft-SPS, all measurements and controls are commanded by the PC. For example: For growing relevant parameters like temperature and pH are controlled and regulated by the Programme. For all analog inputs is a two-point calibration in the visualization integrated. Changes of the measured signals by drifting of the sensors can be easy corrected. medorex e.K. • Industriestrasse 2 37176 Noerten-Hardenberg • Germany Phone +49 (0)5503-8086-62 • Fax -32 Owner Dr. S. Mohazzeb email: [email protected] http://www.medorex.com Kreis-Sparkasse Northeim Kto-Nr. 11825 • BLZ 262 500 01