Lorrca
Lorrca
The Lorrca is an advanced ektacytometer developed by RR Mechatronics for analyzing the rheology of red blood cells (RBCs). It is crucial in researching diseases like sickle cell disease, malaria, and diabetes, and is used in over 20 countries.
Scope and Applications
The Lorrca's capabilities are expanding, particularly in diagnosing stomatocytosis and sickle cell disease. It is used for research into RBC deformability, drug effects, and quality control at blood banks.
Key Features
- Differentiation of Disorders: The Lorrca uniquely differentiates between stomatocytosis and spherocytosis, reducing the risk of inappropriate treatments like splenectomy.
- Sickle Cell Research: It measures RBC sickling tendencies, aiding in medication development and patient monitoring.
Measurement Techniques
- Deformability: Measures RBC elongation under shear stress, indicating blood quality and potential organ failure risks.
- Osmotic Resistance: Assesses RBC deformability across osmotic conditions, useful for diagnosing membrane disorders.
- Aggregation: Evaluates rouleaux formation and dispersion, important for blood bank quality control and clinical trials.
Additional Capabilities
The Lorrca can adjust modalities like viscosity and acidity, enhancing its versatility in various research applications.
Customer Base
The Lorrca is utilized by hematologists, blood banks, pharmaceutical companies, and research institutes focused on blood rheology and related diseases.
Social Responsibility
RR Mechatronics collaborates with the scientific community to advance knowledge in hereditary membrane disorders, positioning the Lorrca as a gold standard diagnostic tool.
Company Overview
RR Mechatronics, founded in 1986 in The Netherlands, specializes in medical analytic instruments, particularly for RBC analysis. It is a leader in automated Westergren ESR instruments and collaborates globally with distributors and OEM partners.
Global Network
Active in over 40 countries, RR Mechatronics ensures local service through certified distributors, emphasizing instrument uptime and maintenance.
Contact Information
For more details, visit www.rrmechatronics.com.
Catalog excerpts
The analysis of the rheology (flowing capacity) of red blood cells is a very specific task. It is vital in the research of some very serious diseases like sickle cell disease, malaria, diabetes, hereditary blood disorders, and other abnormalities that are linked to red blood cells. In close collaboration with our science and technology partners, RR Mechatronics has developed the Lorrca: an ektacytometer with added capabilities. Scientists in over 20 countries use the Lorrca to contribute to research, often in research environments. The Lorrca is also used clinically, especially in the field of...
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Applications Deformability is a measure of the RBC’s condition. It is a good indicator of the blood quality at blood banks but can also indicate future organ failure, among others in diabetics, and allows for the assessment of oxidative stress-related complications. Sickle cells blocking blood flow Sticky sickle cells How Does the Lorrca Work? To evaluate the rheology of blood in different parts of the body it is important to have a technique available that can accurately measure RBC properties such as deformability, stability, and aggregation. The Lorrca incorporates a variety of techniques...
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Aggregation v=au) 0 Ttop Shape recovery stage Disaggregation stage How is it measured? The rouleaux formation is revealed by measuring the change in light absorption following a sudden stop in the applied shear stress on the RBC’s. The rouleaux dispersion threshold value is measured by varying the shear stress until rouleaux formation is only just prevented. This point is marked by the lowest possible amount of light reflection. What does it measure? The Lorrca measures the speed at which rouleaux formation occurs and the minimal shear force at which rouleaux remain dispersed. Other Measurements...
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Our Customers The Lorrca is of great use for hematologists at large laboratories, blood banks, pharmaceutical companies and contract research organizations, scientific research institutes specialized in blood rheology, for research on sickle cell disease and malaria, for oxidative stress related research and so on. The Lorrca is a versatile small footprint instrument that fits on every desk. Social Responsibility The unique collaboration between the scientific world and our R&D department enabled us to develop the Lorrca. The medical world regards the technique used by the Lorrca to be the gold...
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Mechatronics Instruments B.V. De Corantijn 13, 1689 AN Zwaag, The Netherlands P.O. Box 225, 1620 AE Hoorn, The Netherlands T + 31 229 291 129 [email protected] www.rrmechatronics.com Mechatronics USA LLC 20 Altieri Way, Unit 4 Warwick, RI 02886 USA T + 1 401 431-6101 [email protected] www.rrmechatronics.com
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