Leukocyte Apheresis for Autoimmune Diseases such us Ulcerative Colitis,Crohn Disease, Rheumatic Arthritis and others THE COLUMN FOR THERAPEUTIC LEUKOCYTE APHERESIS DEVELOPED BY MEDICA SPA, WITH CUTTING-EDGE FEATURES: • EFFECTIVE AND SELECTIVE REMOVAL OF LEUKOCYTES AND PLATELETS; • EXCELLENT BIOCOMPATIBILITY THANKS TO ITS HIGHLY HYDROPHILIC MediSulfone® MEMBRANE; • STERILIZATION BY BETA RADIATION; NO GAS RESIDUAL; • VERY LOW TOTAL PRIMING VOLUME: 120 ML; PROTOCOL: ONE SESSION PER WEEK FOR FIVE WEEKS

LEUKOCYTE ADSORBER LA25 Blood parameters during each apheresis session (means of 10 patients; samples from leukocyte adsorber outflow) Blood parameters during each apheresis session (means of 10 patients; samples from leukocyte adsorber outflow) Baseline Baseline Treatment 1 2 3 Treatment 4 4 Treatment Treatment 5 5 Treatment Treatment 2 Treatment Treatment 3 Treatment Leukocytes Leukocytes Neutrophils Lymphocytes Monocytes Neutrophils Lymphocytes Monocytes Platelets Platelets SCHEMATIC DRAWING OF EXTRACORPOREAL CIRCULATION CLAMP ACCESS VENOUS CHAMBER BLOOD PUMP ARTERIAL CHAMBER Blood pump flow...