multi-LOC 6F Poster LINC 2014

Product catalog summary

Introduction:
The document discusses the Multi-Loc stenting technology, which aims to minimize damage to the biomechanical properties of stented arterial segments, enable anatomically controlled release of short stents, reduce fractures and lumen loss, and optimize cost-effectiveness by stenting multiple segments with one device.

Method:
After ethical approval, up to five Multi-Loc short stent segments were implanted into the left femoral arteries of six domestic pigs. Long commercially available helical stents were used as controls on the contralateral side. After four weeks of survival under clopidogrel medication, control angiography was performed, and histological evaluation of the stented segments was conducted.

Results:
No fractures were observed in Multi-Loc stents, whereas three out of six control stents fractured. Occlusion was noted in one control limb. The length and degree of stenosis in Multi-Loc stented segments were significantly lower compared to controls.

Conclusion:
Animal experiments demonstrated the technical feasibility of the Multi-Loc stent delivery system. Exact anatomically controlled implantation of short stents is possible, and short stents in actively bent arterial segments do not fracture. Patency of arterial segments after stenting with multiple short stents is superior to single long stent implantation.

Graph Analysis:
The graph compares radial force across different stent designs, indicating that Multi-Loc stents have competitive radial force characteristics.

Catalog excerpts

Mul0-‐Loc: new technology for sten0ng femoro-‐popliteal artery: Proof of concept Klaus Amendt(1), Oliver Dudeck(2), Johannes Jung(3), Heinz Kölble(4) (1): Klinik für Angiologie, Kardiologie, Diakonissenkrankenhaus Mannheim, Germany, (2): Klinik für Radiologie und Nuklearmedizin, Universitätsklinik Magdeburg, Magdeburg, Germany, (3): medicut Stent Technology GmbH Pforzheim, Germany, (4): endoscout GmbH Freiburg, Germany radial force / stentdesigns Newton (N) Right side: 5x 80 mm (Endoscout) Result: 27 d survival aAer implanta7on: 21.02.2013 Method: AAer permission by ethical commi^ee, implanta7on of up to ﬁve Mul0-‐Loc individual short stent segments (13mm long) into the leA femoral arteries of 6 domes7c pigs. As a control, long (60 to 80 mm) commercially available helical stents were implanted into the artery of contralateral side. AAer 4 weeks survival under medica7on with clopidogrel (75mg/d), control angiography was performed, the animals were sacriﬁced and histological (HE-‐staining) evalua7on of the stented arterial segments was performed (→). Animal nr.: 5 domes0c pig. Sten0ng SFA Introduc4on: The idea behind Mul0-‐Loc Sten7ng is: 1. To minimize damage of biomechanical proper7es of stented arterial segments by reducing biomechanical stress between arterial wall and stent especially in close proximity to joints. 2. This new device should enable an exact anatomically controlled release of single (1 to 12) short (10-‐18 mm in length) stents (spot sten7ng) without watermelon seeding eﬀect. 3. To achieve a reduc7on of fractures and lumen loss in the stented segment by myo-‐in7mal hyperplasia. 4. At least to op7mize cost eﬀec7veness, mul7ple femoro-‐popliteal segments can be stented with only one device. Design - Stent-Größe Mul0-‐Loc Results: There was no fracture of Mul0-‐Loc stents compared to 3 out of 6 fractured control stents. Occlusion of the femoro-‐ popliteal axis was observed in one control limb, distal to the stented segment. Length and degree of stenosis in the Mul0-‐Loc stented arterial segments were signiﬁcantly lower compared to control (custom length stent). Conclusion: 1. Animal experiments show technical feasibility of the mul7 stent delivery system (MSDS): Mul0-‐Loc. 2. Exact anatomically controlled implanta7on of

Open the catalog to page 1

multi-LOC 6F Poster LINC 2014

multi-LOC 6F Poster LINC 2014

Catalog excerpts

All Medicut Stent Technology catalogs and technical brochures