Medizym® anti-GAD M

Product catalog summary

Product Overview
Medizym® anti-GAD M is an ELISA test designed for the quantitative determination of antibodies against glutamic acid decarboxylase (GAD65) in human serum. It serves as a serological marker for autoimmune diabetes mellitus type 1, offering high diagnostic efficiency with excellent sensitivity and specificity. The test is automatable and uses recombinant human GAD65 for high specificity.

Diabetes Mellitus Type 1
Type 1 diabetes is a chronic autoimmune disease characterized by the destruction of insulin-producing beta cells in the pancreas, leading to high blood sugar levels. Genetic predispositions and viral infections are risk factors, though the exact causes remain unclear. Islet cell antibodies (ICA), including those against GAD65, are present in 70-80% of patients and serve as prognostic markers for the disease.

Antibodies Against GAD65
GAD65 is an enzyme involved in synthesizing the neurotransmitter GABA. Antibodies against GAD65 are common in patients with type 1 diabetes and those in the prediabetic phase. These antibodies are crucial for diagnosing diabetes mellitus type 1.

Technical Specifications
The Medizym® anti-GAD M assay uses recombinant human GAD65 and is calibrated with the international standard NIBSC code 97/550. Results are expressed in IU/mL. The test demonstrates high precision, with intraassay and interassay variations detailed in the document.

Diagnostic Performance
The test shows a sensitivity of 98.4% and a specificity of 95.3%, based on the analysis of pretested samples from patients suspected of having diabetes mellitus type 1 and unselected blood donors.

Product Features

Ready-to-use reagents, except for the wash buffer
Color- and barcoded reagents for ease of use
Room temperature incubation
CE marked and fully automatable

Contact Information
Medipan GmbH, Ludwig-Erhard-Ring 3, 15827 Blankenfelde-Mahlow OT Dahlewitz, Germany. Phone: +49 (0) 33708 4417 0, Email: [email protected], Website: www.medipan.de

Catalog excerpts

Medizym® anti-GAD M ELISA for the quantitative determination of antibodies against glutamic acid decarboxylase (GAD65) Product Highlights • Serological marker for autoimmune diabetes mellitus type 1 • Excellent diagnostic efficiency with high sensitivity and specificity • Automat

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YOUR RELIABLE PARTNER IN AUTOIMMUNE DIAGNOSTICS 30 Years of Experience, 150 Partners in more than 100 Countries Antibodies against Glutamic Acid Decarboxylase and their Importance in the Diagnosis of Diabetes mellitus Type 1 Diabetes mellitus Type 1 considered important prognostic markers to identify Diabetes mellitus type 1 is a chronic autoimmune patients with an increased risk of developing diabetes disease in which the insulin-producing beta cells mellitus type 1. The combined detection of antibodies of the islets of Langerhans in the pancreas are against GAD65, IA2, ZnT8 and insulin is considered...

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Medizym® anti-GAD M - Enzyme Immunoassay for the Determination of Antibodies against Glutamic Acid Decarboxylase (GAD65) Antigen The Medizym® anti-GAD M immunoassay is based on the use of recombinant human glutamic acid decarboxylase (GAD65). Calibration The Medizym® anti-GAD M immunoassay is calibrated using the international standard preparation NIBSC code 97/550. Quantitative results are expressed in IU/mL. Precision The precision of test results was assessed by the determination of the intra- and interassay variation by the analysis of multiple samples with different antibody activities.

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Product Information Medizym® anti-GAD M Enzyme immunoassay for the quantitative determination of antibodies against glutamic acid decarboxylase (GAD65) in human serum HIGH QUALITY - MADE IN GERMANY • Use of recombinant human glutamic acid decarboxylase (GAD65) for a high specificity • Ready-to-use (exception: wash buffer), color- and barcoded reagents • Quality assured handling in routine laboratories • Incubation at room temperature • Quantitative determination of antibodies against glutamic acid decarboxylase (GAD65) • Calibrated with the international WHO standard preparation NIBSC code 97/550...

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