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Medizym® anti-IA2 M

Medizym® anti-IA2  M

Medizym® anti-IA2 M

Product catalog summary
Product Overview
Medizym® anti-IA2 M is an enzyme immunoassay designed for the quantitative determination of antibodies against protein tyrosine phosphatase (IA2) in human serum. It serves as a serological marker for autoimmune diabetes mellitus type 1, offering high diagnostic efficiency with excellent sensitivity and specificity. The assay is automatable and uses recombinant human protein tyrosine phosphatase for high specificity.
Diabetes Mellitus Type 1
This chronic autoimmune disease results in the destruction of insulin-producing beta cells in the pancreas, leading to high blood sugar levels. Genetic predispositions and viral infections are risk factors, though exact causes remain unclear. Islet cell antibodies (ICA) are present in 70-80% of patients and serve as prognostic markers for the disease.
Antibodies against Tyrosine Phosphatase (IA2)
IA2 is a major autoantigen in type 1 diabetes, with antibodies detectable in most patients and many prediabetic individuals. Their presence correlates with rapid disease progression.
Assay Specifications
The Medizym® anti-IA2 M assay uses recombinant human IA2 and is calibrated with the international standard NIBSC code 97/550. Results are expressed in IU/mL. The assay demonstrates high precision, with intraassay and interassay variations detailed for multiple samples.
Diagnostic Performance
The assay's sensitivity is 94.2%, and specificity is 93.1%, based on analysis of pretested samples from patients and blood donors.
Product Features
The assay is CE marked, fully automatable, and includes ready-to-use reagents (except wash buffer). It is designed for quality-assured handling in routine laboratories, with incubation at room temperature.
Contact Information
Medipan GmbH, Ludwig-Erhard-Ring 3, 15827 Blankenfelde-Mahlow OT Dahlewitz, Germany. Phone: +49 (0) 33708 4417 0, Email: [email protected], Website: www.medipan.de
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Catalog excerpts

Medizym® anti-IA2  M-1

ELISA for the quantitative determination of antibodies against protein tyrosine phosphatase (IA2) Product Highlights • Serological marker for autoimmune diabetes mellitus type 1 • Excellent diagnostic efficiency with high sensitivity and specificity • Automat

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Medizym® anti-IA2  M-2

YOUR RELIABLE PARTNER IN AUTOIMMUNE DIAGNOSTICS 30 Years of Experience, 150 Partners in more than 100 Countries Antibodies against Protein Tyrosine Phosphatase and their Importance in the Diagnosis of Diabetes mellitus Type 1 Diabetes mellitus Type 1 of elevated blood sugar levels and are therefore also Diabetes mellitus type 1 is a chronic autoimmune considered important prognostic markers to identify disease in which the insulin-producing beta cells patients with an increased risk of developing diabetes of the islets of Langerhans in the pancreas are mellitus type 1. The combined detection...

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Medizym® anti-IA2  M-3

Antigen The Medizym® anti-IA2 M immunoassay is based on the use of recombinant human protein tyrosine phosphatase (IA2). Calibration The Medizym® anti-IA2 M immunoassay is calibrated using the international standard preparation NIBSC code 97/550. Quantitative results are expressed in IU/mL. Precision The precision of test results was assessed by the determination of the intra- and interassay variation by the analysis of multiple samples with different antibody activities.

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Medizym® anti-IA2  M-4

Product Information Medizym® anti-IA2 M Enzyme immunoassay for the quantitative determination of antibodies against protein tyrosine phosphatase (IA2) in human serum HIGH QUALITY - MADE IN GERMANY • Use of recombinant human protein tyrosine phosphatase (IA2) for a high specificity • Ready-to-use (exception: wash buffer), color- and barcoded reagents • Quality assured handling in routine laboratories • Incubation at room temperature • Quantitative determination of antibodies against human protein tyrosine phosphatase (IA2) • Calibrated with the international WHO standard preparation NIBSC code...

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