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Medizym® T.R.A. human

Medizym® T.R.A. human

Medizym® T.R.A. human

Product catalog summary
Product Overview
Medizym® T.R.A. human is a third-generation ELISA designed for the quantitative determination of antibodies against the thyrotropin (TSH) receptor (TRAb), primarily used in diagnosing Graves' disease. It offers high diagnostic efficiency with excellent sensitivity and specificity and is suitable for automation.

Graves' Disease
Graves' disease is an autoimmune disorder affecting the thyroid gland, leading to goiter and excessive production of thyroid hormones T3 and T4. It is the most common cause of hyperthyroidism in iodine-sufficient regions, affecting women more than men. Symptoms include insomnia, irritability, weight loss, and exophthalmos. Diagnosis involves clinical assessment and laboratory tests for TSH receptor antibodies.

Diagnosis and Therapy
Diagnosis is confirmed by detecting TRAb, which indicates Graves' disease. In the absence of TRAb, other antibodies like TPO and Tg are assessed. Treatment involves antithyroid drugs, with surgery or radioiodine therapy as potential options if remission occurs.

Product Specifications
The Medizym® T.R.A. human assay uses recombinant human TSH receptor and monoclonal antibodies. It is calibrated with the international standard NIBSC code 08/204, with results expressed in IU/L. The assay demonstrates high precision and is CE marked.

Performance and Precision
The assay's diagnostic sensitivity is 95%, and specificity is 99%, based on tests with patients and blood donors. Intraassay and interassay precision are evaluated with CV percentages provided for different samples.

Contact Information
Medipan GmbH, Germany. Phone: +49 (0) 33708 4417 0, Email: [email protected], Website: www.medipan.de
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Catalog excerpts

Medizym® T.R.A. human-1

Medizym® T.R.A. human ELISA for the quantitative determination of antibodies against thyreotropin (TSH) receptor (TRAb) Product Highlights • ELISA of the third generation for diagnosis of Graves´ disease • Excellent diagnostic efficiency with high sensitivity and specificity • Automa

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Medizym® T.R.A. human-2

YOUR RELIABLE PARTNER IN AUTOIMMUNE DIAGNOSTICS 30 Years of Experience, 150 Partners in more than 100 Countries Antibodies against Thyreotropin (TSH) Receptor and their Importance in the Diagnosis of Graves´ Disease Graves´ Disease Graves’ disease is an autoimmune disease of the The diagnosis of Graves’ disease is made on the thyroid gland that leads to enlargement (goiter) basis of the clinical symptoms and confirmed by and an excessive production of the thyroid laboratory diagnostics by determining antibodies hormones triiodothyronine (T3) and thyroxine against the thyrotropin receptor (thyroid-stimu-...

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Medizym® T.R.A. human-3

Medizym® T.R.A. human - Enzyme Immunoassay for the quantitative Determination of Antibodies against the TSH receptor (TRAb) Antigen and Antibody The competitive Medizym® T.R.A. human immunoassay is based on the use of recombinant human TSH receptor and monoclonal antibodies. Calibration The Medizym® T.R.A. human immunoassay is calibrated using the international standard preparation NIBSC code 08/204. Quantitative results are expressed in IU/L. Precision The precision of test results was assessed by the determination of the intra- and interassay variation by the analysis of multiple samples with...

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Medizym® T.R.A. human-4

Product Information Medizym® T.R.A. human Competitive enzyme immunoassay for the quantitative determination of antibodies against the TSH receptor (TRAb) in human serum HIGH QUALITY - MADE IN GERMANY • Use of a combination of recombinant human TSH receptor and monoclonal antibody • Ready-to-use (exception: conjugate and wash buffer) and barcoded reagents • Quality assured handling in routine laboratories • Incubation at room temperature • Quantitative determination of antibodies against the human TSH receptor (TRAb) • Calibrated with the international standard preparation NIBSC code 08/204 •...

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