the next generation four modality pre-clinical imaging platform SPECT/MRI, PET/MRI, SPECT/CT, PET/CT nanoScan® products are the first in the following: - achieve the breakthrough 10,000 cps/MBq SPECT sensitivity - 275 µm visible resolution for SPECT - 700 µm visible resolution for PET - quantification accuracy over 97% for SPECT & PET - in-line SPECT/MRI multimodality system - in-line PET/MRI multimodality system

MEDISO Medical Imaging Systems Traditions in research and development Mediso Medical Imaging Systems with headquarters in Budapest is a dynamic supplier of nuclear medicine and modern hybrid imaging techniques to healthcare and research institutes around the world. The company was founded in 1990 by experts of the leading research and manufacturing company of the region carrying on their proficiency in developing and producing nuclear equipment since 1960. At present Mediso continue its legacy in researching innovative medical imaging technologies and developing cutting edge preclinical and clinical...

Family concept Unique versatility in molecular imaging modalities nanoScan® - the four modality in vivo molecular imaging platform Members of the nanoScan® Family combine the industry’s highest performing microscopy level of NM imaging supported by excellent MRI and CT performance. The ultimate versatility and in-line combinations of the systems are based on common software, common animal handling platform and easy on-site upgrade possibility, thus fulfil all demands of your growing and long term research requirements. With the nanoScan® Family Mediso designed a platform that can satisfy the...

Family MRI* - 100 µm resolution - 500 mT/M gradient - maintenance free magnet MRI SPECT - 275 µm visible resolution - over 97% quantification accuracy - up to 10,000 cps/MBq sensitivity by 100 pinholes nanoScan® SPECT/CT - 30 µm resolution - 80 W X-ray power - ultra low dose acquisition protocol

Common Versatile Platform 1. MRI MRI of a 30 g Nu/Nu mouse with flank tumor xenograft imaged post i.v. injection of iron oxide particulate contrast agent using a T1-weighted GRE sequence, imaging duration 6.5 min. 2. PET/MRI 18 F-FDG PET in a 30 g Nu/Nu mouse with flank tumor xenograft imaged in the last 10 minute frame of a 60 min. dynamic scan post i.v. injection of 4 MBq of radioactivity. MRI acquisition details as in image 1. 3. PET 18 F-FDG biodistribution image in a 32 g mouse during a 5 minute scan, immediately after i.v. injection of 3.4 MBq of radioactivity. Vascular system is visible....

Shared components NuclineTM 2.0 - all modality acquisition software - Common acquisition platform for all four modalities - Integrates wide range of functionalities of acquisition, calibration, data management, reconstruction and visualization. - DICOM standard images stored in DICOM server - Flexible and easily customized daily workflow protocols. 3D SPECT / PET - reconstruction software Tera-TomoTM 3D SPECT reconstruction principle with on the fly system matrix generation position dependent intrinsic resolution PSF model Monte Carlo detector crystal model realistic pinhole collimator simulation...

Data Workflow / Workstations Acquisition / Processing WS - NuclineTM - Tera-TomoTM 3D SPECT - Tera-TomoTM Real time CT - InterViewTM FUSION Post-processing WS - InterViewTM FUSION - Tera-TomoTM 3D SPECT - Tera-TomoTM Post CT - Online archiving Tera-TomoTM 3D PET „real“ reconstruction Tera-TomoTM 3D PET „post“ reconstruction Windows based SPECT / MRI / CT modalities Post-processing / reconstruction / archiving unit Linux based PET modality Real time acquisition / Processing / reconstruction unit MultiCell Animal Anesthesia / Imaging Chamber - Multimodality imaging for PET+CT+SPECT+MRI modalities...

Worldwide installed base of pre-clinical and clinical systems developed and manufactured by Mediso 86 countries 100 pre-clinical systems 900 clinical systems Conformance Statement Product design, development, production and services comply with ISO 9001:2001 and with ISO 13485:2004. The nanoScan multimodality molecular imaging family conforms to EC Directive 93/42/EEC; Annex II, Article 3 Full Quality Assurance System Medical Devices Design and safety testing has been performed in accordance with IEC 60601-1 and IEC 60601-1-2 EMC standards. ® Safety labels are attached to appropriate places on...