nanoScan PET/CT
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in vivo molecular and preclinical imager The first sub-half mm3 PET volumetric resolution PET/CT with exceptional image quantification - accuracy over 97 % Preclinical Line

PET/CT Introduction To unveil fine and accurate details of living organisms, scientists need high resolution, high-sensitivity, time-dependent quantitation. Definition of kinetic constants of biological processes also became a basic scientific aim. Offering solutions for modern-day science, Molecular Imaging has gone a long way in a relatively short time to become an indispensable tool for virtually any scientist. One of the most established methods in the field, Positron Emission Tomography (PET) remains the cutting edge and it is still the gold standard in Molecular Imaging. The reasons...

Relying on proven excellence The gold standard of Molecular Imaging using Mediso's PET/CT technology Animal imaging studies are performed to provide reliable quantitative results. Moreover, those studies often demand a low limit of detection with high sensitivity. As imaging modality, PET will remain the gold standard of quantitation in biology. This is due to PET's proven measurement accuracy throughout several orders of magnitude and exceptional, unparalelled biological sensitivity inherent in isotopic tracing. PET's leadership in quantitation and sensitivity is established by robust...

PET/CT Acquisition / Gantry Touchscreen User Interface - Shared interface for PET and CT - Touch-controlled bed movements - Online animal monitoring - On the fly PET persistence scope function MultiCell Animal Anesthesia / Imaging Bed - Automated positioning with µm accuracy - Closed circuit anesthesia system integrated into a pathogen-free imaging chamber - One-click dockable PET / CT / SPECT / MRI compatible imaging chamber - Integrated heating / temperature control and monitoring - Respiratory and ECG gating and monitoring ® - Compatible with NanoSPECT/CT systems Fast and Easy Instrument...

No compromise in image quality PET Detector Ring - LYSO crystal full ring geometry - 1.12 x 1.12 x 13 mm3 pixel size - 512 ch/module flat panel sensor - 12 cm transaxial FOV - Aperture: 16 cm - 0.3 mm3 spatial resolution by Tera-TomoTM 3D PET DOI engine X-Ray CT System - Wide energy range X-Ray tube - 7 µm focal spot size - High DQE at low dose detector - Variable zoom (35 mm - 120 mm FOV) - Closed box X-Ray system High Precision Gantry - Very precise and robust rotational bearing and drive - Exceptionally stable gantry with 4 axis movements - Large bore size with 16 cm opening - Open...

PET Subsystem Structure Mediso's traditions in nuclear detection technology and fine precision mechanics date back almost a century. Leveraged by our expertise gathered across generations of patented, cutting-edge instrument innovations, the company has designed and built the most advanced PET detector present in the market. Mediso nanoScan® PET/CT's LYSO crystal pins are the most tightly packed (92%) and smallest in the industry, minimizing dead detector space. Large-surface modular detector design together with the large detector ring diameter (largest among currently available PET/CT...

0.3 mm resolution by Tera-Tomo 3D PET engine Ultra-fast PET data flow and processing The combination of Mediso high-end PET detector with a very advanced 3D Teraflop Computing for Tomography: Tera-TomoTM 3D PET reconstruction engine, also developed by Mediso leads to a PET resolution very near the physical limits. Data collected by the PET detector are sorted and processed using a proprietary, custom-designed circuit and application specific FPGA chip. The data stream is transmitted to the image reconstruction engines, based on a cluster of GPUs. These ultra-high performance systems enable...

Quantitative reconstruction with high sensitivity This is available to every nanoScan® PET/CT user. Receptor binding potential or high precision SUV studies are robustly performed on the nanoScan® PET/CT. Axial distance from center (mm) Activity concentration linearity for quantification Absolute sensitivity according to NEMA NU 4-2008: > 8.0% Maximum sensitivity: > 9.0% (1 50-750 keV window) Representation of quantitative accuracy of the nanoScan® PET/CT's PET component over 2 orders of magnitude. The radioactivity measured in the syringes is well repeated by the reconstructed values. 700...

Exclusive PET Imaging Performance Three plane sections of a Nude mouse bearing FaDu xenograft tumor. 34 MBq of 64Cu-labelled antibody fragment injected i.v., imaging 24 h post injection for 20 min. Note the accumulation in kidney cortex and the tumor uptake inhomogeneities. MIP image of the same Nude mouse. F-fluoro-deoxy-glucose uptake in rat brain, PET/CT MIP image. 30 MBq of 18F-FDG injected into awake rat and imaged 50 min p.i. for 20 min.

CT Subsystem Fine structures revealed in high quality at low dose Mediso designed a low-dose, ultra-fast but high quality zoomable cone-beam X-ray CT to complement nanoScan®'s exceptional PET image qualities. Indeed the X-ray CT alone is a whole-body imaging system on its own right. Offering a very large detector surface and large bore with helical scanning possibility, variable zoom (1.25-7.6) and high power X-ray source (up to 80W) gives the ability to the CT of nanoScan® PET/CT to image the largest variety of species in the industry including larger animals or a whole body mouse scan in...

MultiCell Animal Anesthesia / Imaging Chamber Continuous digital temperature control: by closed circuit airflow integrated into the wall of the chamber – avoiding the side effect of the open airflow (dehydration of the eyes, contamination by pathogens etc.) Embedded anesthetic gas connection: for any isoflurane system through dockable connection to the mouse /rat nose cone via closed circuit tubes integrated into the wall of the chamber Integrated animal head mounting: for precise and reproducible animal positioning 4D/5D imaging accessories: dockable connections for ECG and respiratory...