in vivo molecular and preclinical imager The first integrated preclinical whole-body PET/MRI with 700 µm PET and 100 µm MRI spatial resolution Preclinical Line

PET/MRI Introduction Welcome to a fascinating new world of images that will change your research. Welcome to a stunning interplay of anatomy and function. Welcome to nanoScan® PET/MRI. By combining the world's highest-performing PET system and breakthrough compact MRI technology, nanoScan® PET/MRI gives you the power to plan discoveries with no precedent. With the first member of the new nanoScan® imaging family, Mediso is pleased to provide again a revolutionary new platform for the life scientists. Using the one-of-a-kind, easy but powerful MRI technology of nanoScan® PET/MRI, soft tissue images...

The routine research tool of the future Combining the best of both modalities to answer your biological questions Flexible and affordable, the nanoScan® integrated PET/MRI offers the industry's best performance, quantitative highresolution PET imaging combined to great anatomical details of the MRI – all in one in-line system. A single, integrated PET/MRI scanner has the ability to fulfill all the imaging needs of your laboratory. If your work focuses on PET, the nanoScan® PET/MRI will improve resolution, sensitivity and quantitation for you with its unique high-end PET component. Besides the...

PET/MRI MRI Magnet - 1 Tesla permanent magnet - Gradient strength: 450 mT/m - < 5 ppm homogenity - 100 µm spatial resolution - Integrated gradient coil - Integrated RF shielding RF Coils - Multiple solenoid coils available - 35 mm Tx/Tr for mouse whole body imaging - 60 mm Tx/Tr for rat whole body imaging - Mouse head coil: ~ Ø 22-25 mm - Custom coils available upon request Fast, Easy Instrument Installation - Cryogen-free design - Compact size: 800 x 1200 x 1400 mm - Weight: 1170 kg - Zero magnetic fringe field - No need for additional RF shielding in the lab

No compromise in image quality PET/MRI Acquisition / Gantry Touchscreen User Interface - Common interface for PET and MRI - Touch-controlled bed movements - Online animal monitoring - On the fly persistence monitor function PET Detector Ring - LYSO crystal full ring geometry - 1.12 x 1.12 x 13 mm pixel size - 512 ch/module flat panel sensor - 12 cm transaxial FOV - 700µm spatial resolution by Tera-TomoTM 3D PET engine MultiCell Animal Anesthesia / Imaging Bed - Automated positioning with µm accuracy - 100% RF shielding for MRI imaging - Closed circuit anesthesia system integrated into a pathogen-free...

PET Subsystem Structure Mediso's traditions in nuclear detection technology and fine precision mechanics date back almost a century. Leveraged by our expertise gathered across generations of patented, cutting-edge instrument innovations, the company has designed and built the most advanced crystal-based PET detector present in the market. The fine crystal pins and highest packing fraction combined with a series of innovations in optical design has led to a PET detector with unmatched combination of sensitivity and resolution. Due to the multilayered magnetic shielding of the PET-ring supported...

700µm resolution by Tera-TomoTM 3D PET engine Ultra-fast PET data flow and processing The combination of Mediso high-end PET detector with advanced 3D Teraflop Computing for Tomography: Tera-TomoTM 3D PET reconstruction engine leads to a PET resolution near the physical limits. Data collected by the PET detector are sorted and processed using a proprietary, custom-designed circuit and application specific FPGA chip. The data stream is transmitted to the image reconstruction engines, based on a cluster of GPUs. This ultra-high performance system enable you to simultaneously acquire and reconstruct...

PET Subsystem Quantitative reconstruction with high sensitivity This is available to every nanoScan® PET/MRI user. Receptor binding potential or high precision SUV studies are robustly performed on the nanoScan® PET/MRI. Absolute sensitivity (%) Axial distance from center (mm) Activity concentration linearity for quantification Quantitative accuracy: > 97% Absolute sensitivity according to NEMA NU 4-2008: > 8.0% Maximum sensitivity: > 9.0% (150-750 keV window) Representation of quantitative accuracy of the nanoScan® PET/MRI's PET component over 2 orders of magnitude. The radioactivity measured...

Exclusive PET Imaging Performance Left ventricle Brown fat Left ventricle Right ventricle Spinal marrow Right ventricle Whole body PET imaging of glucose utilization in a mouse (10 MBq 18F-FDG, 50 min p.i., 30 min imaging time). Tissues with high glucose utilization rate (heart muscle, brown fat, spinal bone marrow, Harderian glands) are visible. Image courtesy of Karolinska Institute Olfactory bulb Harderian gland Ventricle Cortex Cerebellum Cortex Lateral ventricle Thalamus Mouse brain F-FDG (20 MBq i.v., 30 min PET, 23 min MRI) PET/MRI study in an anesthetized animal. Besides obvious cortical...

MRI Subsystem The MRI component: designed to meet the needs of every scientist The MRI subsystem is tuned to meet all the anatomical imaging needs of even the most discerning scientists. The compact, high-performance magnet system is developed by the pioneer in the field of compact permanent MRI systems – Aspect Imaging. The 1 Tesla is optimized to perform fast, routine studies and obtain high resolution (routinely up to 100 microns) soft tissue images with appropriate signal to noise ratio. In fact, a majority of MRI imaging applications can be performed with this compact MRI system but at a...

100µm resolution by compact MRI technology An MRI system that is easy to use and efficient in soft tissue contrast The MRI system's simplicity of operation matched with its powerful imaging capabilities makes it easy to correlate functional PET data with anatomical morphology. The subsystem is unusually quiet as its whisper gradients generate less than 20 dB of noise. No brain study will be affected by excessive MRI-generated operating noise, notwithstanding the fact that nanoScan® PET/MRI is such a silent system that the whole staff of an imaging laboratory will like to use it. A variety of...