Preclinical Imaging Systems PET/MRI PET/CT High performance systems optimized for absolute quantification and high throughput scanning

Preclinical imaging systems nanoScan® Family With the nanoScan® Family concept Mediso provides a unique and flexible solution for the demands of your imaging facility. Members of the nanoScan® Family share the user friendly Nucline™ acquisition software platform for all modalities, with intuitive workflow and effortlessly customizable protocols. Both post-processing programs of InterView™ FUSION and VivoQuant™ are able to co-register and analyze multiple images across all modalities. MultiScan LFER 150 PET/CT The MultiScan Family aims to provide imaging tools for non-human primate, large animal...

nanoScan® PET subsystems Main advantages -- More than 100 installed PET-based cameras worldwide: -- ensuring reliable systems with matured technology -- supported by proven and experienced service and application network -- Highest PET resolution (using the industry’s most advanced pixelated modular LYSO detectors) -- Exceptionally high count rate tolerance supporting high activity studies of multiple animals or short half-life isotopes -- State-of-the-art Tera-TomoTM 3D PET image reconstruction engine -- Easy access to the animal from both the front and the back of the PET/CT gantry -- High...

nanoScan® PET subsystems Tera-TomoTM 3D PET reconstruction engine Monte Carlo based full detector modelling and DOI estimation Modelling of detector geometry Advanced corrections for energy, position, time, random deadtime etc. CT/MRI-based attenuation, scatter and positron range correction Optimized reconstruction protocols for various applications Count rate [kcps] Mouse Rat Four-mouse scan scan scan 1000 Count rate [kcps] Count rate [kcps] Mouse Rat Four-mouse Mouse Rat Four-mouse scan scan scan scan scan scan Uniform volumetric resolution in axial direction using Tera-TomoTM 3D PET Uniform...

nanoScan® PET subsystems Exclusive PET imaging performance Three plane sections of a nude mouse bearing FaDu xenograft tumor. 34 MBq of 64Cu-labelled antibody fragment injected i.v., imaging 24 h post injection.Note the accumulation in kidney cortex and the tumor uptake inhomogeneities. MIP image of the same nude mouse. F-Fallypride (D2/D3 receptor antagonist) uptake in rat brain. PET/MRI image and corresponding Time Activity Curve of the accumulation. Injected activity 11.7MBq. CT subsystem To complement the nanoScan® PET’s exceptional qualities Mediso designed unique combination of low dose,...

MRI subsystem: 3T cryogen-free or 1T permanent High imaging performance 3T MRI – Excellent resolution with high sensitivity on translational 3T field strength Mediso accepts no compromises in the imaging performance of the nanoScan® PET/MRI 3T system. Due to tailor-made shielding, developed as an integral part of the specially designed and shimmed, low fringe field cryogen-free magnet, the supreme performance of the well-established PET subsystem remains intact. The nanoScan® MRI 3T system delivers images with excellent resolution together with high sensitivity. Thanks to its clinical magnetic...

Animal handling Available MultiCellTM imaging chambers Mouse Standard Inner space: 36 x 290 mm Outer dimensions: 40 x 460 mm Up to 80 g Rat Standard Inner space: 65 x 440 mm Outer dimensions: 70 x 540 mm Up to 600 g Two-Mouse Inner space: 2 x 24 x 260 mm Outer dimensions: 56 x 470 mm Up to 2 x 35 g Four-Mouse Inner space: 4 x 30 x 194 mm Outer dimensions: 85 x 524 mm Up to 4 x 60 g Rat - XXL Inner space: 102 x 510 mm Outer dimensions: 110 x 650 mm Up to 1.5 kg Rabbit Inner space: 150 x 600 mm Outer dimensions: 160 x 760 mm Up to 6.5 kg PrepaCell™ Preparation station ------ Two one-click docking...

Under the hood PET/MRI MRI Magnet Touchscreen interface 3 Tesla cryogen-free - Gradient strength: > 450 mT/m - +/- 0.5 ppm over 50 mm DSV - Stability: <0.05 ppm/hour - ≤ 50 µm spatial resolution - Integrated RF and magnetic shielding – low floor space requirement and no need of a dedicated room -- Shared interface for PET and MRI -- Imaging chamber movement control through touchscreen interface or from the acquisition workstation -- Continuous physiological monitoring -- PET persistence scope function LYSO crystal full ring geometry Up to 12 cm transaxial FOV Aperture: up to 16 cm Up to 0.3 mm3...

Under the hood PET/CT Touchscreen interface -- Shared interface for PET and CT -- Imaging chamber movement control through touchscreen interface or from the acquisition workstation -- Continuous physiological monitoring -- PET persistence scope function LYSO crystal full ring geometry Up to 12 cm transaxial FOV Aperture: up to 16 cm Up to 0.3 mm3 spatial resolution by Tera-TomoTM 3D PET reconstruction engine Animal handling High Precision Gantry -- Direct access to the animal during scan -- Zero dead space: easy manipulation of the animal (injection, blood sampling, etc.) -- Automated imaging...

Operating hardware Researcher’s room Acquisition room Acquisition workstation nanoScan® gantry Electronic cabinet Room requirements Post-Processing workstation Acquistion Room All nanoScan® PET-based systems Minimum acquisition room size: 10 m2 Single phase operation 115 / 230 V No additional RF shielding required No additional magnetic shielding required – self shielded systems 4000 mm System specific parameters Researcher’s room nanoScan® PET/CT Size (W x D x H): 1300 x 1910 x 1590 mm Weight: 1210 kg No cryogen or water cooling required Standard air conditioning is sufficient -- Size (W x D...

Software solutions Nucline™ all modality acquisition software Nucline™ is an easy to use and intuitive interface for high throughput workflow across all the nanoScan® Family systems - there is no need to learn different software solutions. In a 21CFR Part 11 compliant data management environment predefined and customizable acquisition protocols make experiments daily routine. The integrated gantry with common coordinates gives the opportunity to seamlessly co-register images allowing for accurate image quantification. Furthermore, list mode data collection provides wide range of flexibility in...