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Preclinical Imaging Systems SPECT/MRI SPECT/CT High throughput versatile imaging system with absolute quantification

Preclinical imaging systems nanoScan® Family With the nanoScan® Family concept Mediso provides a unique and flexible solution for the demands of your imaging facility. Members of the nanoScan® Family share the user friendly Nucline™ acquisition software platform for all modalities, with intuitive workflow and effortlessly customizable protocols. Both post-processing programs of InterView™ FUSION and VivoQuant™ are able to co-register and analyze multiple images across all modalities. Main advantages of the nanoScan® SPECT systems -- More than 100+ installed SPECT-based cameras worldwide --...

nanoScan® SPECT subsystem Mediso has 15 years of experience in SPECT development supported by strong and reliable team and several international cooperation partners. Thanks to this high-level knowledge and experience, Mediso has a proven, sizeable installation base from its SPECT-based cameras. Proprietary and patented* multi-pinhole aperture technology -- Cutting-edge aperture design resulting in market leading imaging performance -- Versatile, well-balanced, multi-pinhole apertures providing large single position field of view, high sensitivity and sub-mm resolution at the same time --...

nanoScan® SPECT subsystem SPECT performance Exclusive imaging performance with ultra-low activity MIP images of whole-body helical mouse scan. Injected: 99mTC MDP 4 hours p.i. Scan time: 45 min Fine details reserved even with 0.9 MBq activity in the animal. Market leading absolute quantification even with 125I injected in rat Absolute quantitative SPECT images are the result of a fully integrated SPECT and CT/MRI modality and state-of-the-art, robust SPECT reconstruction engine. The highest level of integration means not only a perfectly co-registered multimodality system, but also the...

nanoScan® SPECT subsystem Packages for specific applications - from animal preparation to sophisticated/ automatized evaluation Beside the core application capabilities nanoScan SPECT/CT or SPECT/MRI offers a large number of specific application options. Mediso provides application packages including dedicated HW components, acquisition protocol, optimized reconstruction parameters, high-end evaluation solution and a comprehensive application note describing the whole imaging procedure from animal preparation to available publications in the field. Highest throughput three-mouse imaging...

MRI subsystem High imaging performance - Excellent soft tissue contrast Easy-to-use workflow Several 2D and 3D pulse sequences The ease of use of the MRI subsystems matched with their powerful imaging capabilities, makes it simple to correlate functional SPECT data with anatomical morphology. Whole-body mouse Whole-body rat Dedicated coils for mouse brain (optional) Dedicated coils for rat brain (optional) 3D Localiser Quick sagittal Localiser Spin Echo (SE) 2D and 3D Fast Spin Echo (FSE) 2D and 3D Gradient echo 3D (GRE) Inversion Recovery Echo (IR-SE, IR-GRE) Angiography with contrast...

Animal handling Available MultiCellTM imaging chambers Mouse Standard* Inner space: 36 x 290 mm Outer dimensions: 40 x 460 mm Up to 80 g Rat Standard* Inner space: 65 x 440 mm Outer dimensions: 70 x 540 mm Up to 600 g Two-Mouse Inner space: 2 x 24 x 260 mm Outer dimensions: 56 x 470 mm Up to 2 x 35 g Three-Mouse Inner space: 3 x 24 x 220 mm Outer dimensions: 60 x 500 mm Up to 3 x 35 g Rat - XXL Inner space: 102 x 510 mm Outer dimensions: 110 x 650 mm Up to 1.5 kg Rabbit Inner space: 150 x 600 mm Outer dimensions: 160 x 760 mm Up to 6.5 kg * Dimensions are valid for the standard SPECT/CT...

Under the hood SPECT/MRI Touchscreen interface - - - - Shared interface for SPECT and MRI Bed movement control through touchscreen interface or from the acquisition workstation Online animal vital function monitoring SPECT persistence scope function 1 Tesla permanent magnet Gradient strength: 450 mT/m < 5 ppm homogenity 100 μm spatial resolution Integrated gradient coil Integrated RF shielding Back door access for easy coil exchange Multiple solenoid coils available 35 mm Tx/Tr for mouse whole body imaging 60 mm Tx/Tr for rat whole body imaging Custom coils available upon request Animal...

Under the hood SPECT/CT Touchscreen interface - - - - SPECT Detector Shared interface for SPECT and CT Bed movement control through touchscreen interface or from the acquisition workstation Online animal vital function monitoring SPECT persistence scope function Up to 250 mm transaxial FOV 300 µm spatial resolution 13 000 cps/MBq sensitivity Patented M3 multi-pinhole technology Up to 144 pinholes Upgrade with PET subsystem to an integrated triple modality nanoScan® SPECT/CT/PET PET Subsystem Coincidence based full LYSO ring PET subsystem with various detector configurations (module /...

Operating hardware Researcher’s room Acquisition room nanoScan® gantry Acquisition workstation Electronic cabinet Post-Processing workstation Room requirements - - - - - - - - - Minimum room size: 12 m2 Weight: 1880 / 830 kg Size (W x D x H): 1136 x 2177 x 1550 mm / 1345 x 1757 x 1678 mm No additional RF shielding required Single phase operation 115 / 230 V Power consumption 2500 W / 1700 W No cryogen or water cooling required Ordinary air conditioning is sufficient Ethernet connection for remote servicing (parameretrs refer to SPECT/MRI and SPECT/CT respectively) Electronic cabinet Only...

Software solutions Nucline™ all modality acquisition software Nucline™ is an easy to use and intuitive interface for high throughput workflow across all the nanoScan® Family systems - there is no need to learn different software solutions. In a 21CFR Part 11 compliant data management environment predefined and customizable acquisition protocols make experiments daily routine. The integrated gantry with common coordinates gives the opportunity to seamlessly co-register images allowing for accurate image quantification. Furthermore, list mode data collection provides wide range of flexibility...