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Clinical studies

Clinical studies
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Clinical studies

Product catalog summary
Overview of Clinical Studies on Low Level Laser Therapy (LLLT)
Introduction: This document provides a comprehensive overview of clinical studies evaluating the efficacy of Low Level Laser Therapy (LLLT) or Photobiomodulation Therapy (PBMT) in treating various musculoskeletal and other disorders.
Key Findings:
  • Pain and Inflammation Reduction: LLLT has been shown to decrease pain and inflammation, as evidenced by studies conducted by Cotler et al. and Walski et al.
  • Tissue Regeneration: The therapy increases the rate of hyaline cartilage and skeletal muscle fiber regeneration, promoting faster recovery from injuries.
  • Blood Flow and Healing: LLLT enhances blood flow, angiogenesis, and neovascularization, which are critical for wound healing and recovery.
  • Stem Cell Proliferation: The therapy stimulates stem cell proliferation, aiding in tissue repair and regeneration.
  • Recovery and Scarring: It reduces recovery time, swelling, and scar tissue formation, as supported by studies from Fisher et al. and Alsharnoubi et al.
Clinical Applications: Over 1200 human clinical trials have demonstrated the benefits of LLLT in treating conditions such as arthritis, tendinopathies, sprains, strains, wound healing, fractures, peripheral neuropathies, and more.
Clinically Proven Benefits:
  • Improved pain relief and earlier discontinuation of NSAIDs and opioids.
  • Decreased edema, scarring, and recurrence of injury.
  • Increased patient satisfaction and range of motion.
  • Faster return to daily activities and work without side effects.
Conclusion: The BIOFLEX® family of photobiomodulation medical devices offers significant clinical benefits, making it a valuable tool in medical treatments.
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Catalog excerpts

Clinical studies-1

Clinically Proven Benefits + Improved pain relief + Earlier discontinuation of NSAIDs and opioids + Decreased edema and stiffness + Decreased scarring + Decreased recurrence of injury + Increased patient satisfaction + Decreased recovery time and subsequent return to work + Increased range of motion + Faster return to activities of daily living No side effects Over 1200 human clinical trials have been published in peer reviewed journals evaluating the benefits of low level laser therapy (LLLT) or photobiomodulation therapy (PBMT) for arthritis, tendinopathies, sprains, strains, wound healing, fractures, peripheral neuropathies, injured nerves, traumatic brain injuries, temporomandibular joint and numerous other disorders. As a result of these studies, there are 10 clinically proven benefits claims for the BIOFLEX® family of photobiomodulation medical devices. 1. Decreases pain 13 6. Increases angiogenesis and neovascularization 3. Increases rate of hyaline cartilage regeneration 8. Reduces time to recovery 5 4. Increases rate of skeletal muscle fibre regeneration 9. Decreases swelling 6 5. Increases blood flow 7 10. Reduces scar tissue formation 8 H B Cotler, R T Chow, M R Hamblin, J Carroll. The Use of Low Level Laser Therapy (LLLT) For Musculoskeletal Pain. MOJ Orthop Rheumatol 2015;2(5):00068 T Walski, K D^browska, A Drohomirecka, N J^druchniewicz, N Trochanowska-Pauk, W Witkiewicz, M Komorowska. The effect of red-to-near-infrared (R/NIR) irradiation on inflammatory processes. Int J Radiat Biol. S GN, Kamal W, George J, Manssor E. Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia. Lasers Med Sci. 2017 Feb;32(2):297-303. J Nakano, H Kataoka, j Sakamoto, T Origuchi, M Okita, T Yoshimura. Low-level laser irradiation promotes the recovery of atrophied gastrocnemius skeletal muscle in rats. Exp Physiol. 2009 Sep;94(9):1005-15. SR Fisher, JH Rigby, JA Mettler, KW McCurdy. The Effectiveness of Photobiomodulation Therapy Versus Cryotherapy for Skeletal Muscle Recovery: A Critically Appraised Topic. J Sport Rehabil. 2019 Jul 1;28(5):526-531. Apostolos Stergioulas. Low-level laser treatment can reduce edema in second degree ankle sprains. J Clin Laser Med Surg. 2004 Apr;22(2):125-8. doi: 10.1089/104454704774076181. I Frangez, K Cankar, H Ban Frangez, DM Smrke. The effect of LED on blood microcirculation during chronic wound healing in diabetic and non-diabetic patients-a prospective, double-blind randomized study. j Alsharnoubi, ke Shoukry, MW Fawzy, O Mohamed. Evaluation of scars in children after treatment with low-level laser. Lasers Med Sci. 2018 Dec;33(9):1991-1995.

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