BOVINE BONEGRAFT NATURAL BONE SUBSTITUTE

Manufactured by /l/lsdPafk BOVINE BONEGRAFT Bovine bonegraft manufactured by Sintering Technology of MedPark r \ ■ High blood permeability, similar pH to body fluids, rapid new bone formation without inflammatory reactions ■ Sticky bone formation through PRF and CGF with independent process technology ■ Selection of proper size of graft materials for suitable environment for bone regeneration ■ Increased micropores allows the migration of osteoblasts for increasing new bone formation ■ Enhanced hydrophilicity allows user to manipulate easily ■ Applicable to various indication such as Socket Preservation,...

Perforations similar to human bones High pore rate confirmed by the Porosimeter Test Rough surface of microstructure makes osteoblast stick to the surface easily (* Measure the size and pore rate of pores present on the sample surface by adsorbing mercury on the specimen) Excellent bone formation & biocompatibility Product ‘B’ Cell viability (%) [ Osteoblasts Differentiation Test ] [ Cytotoxicity Test ] · Safe and stable bonegrafts without toxicity · Cell survival rate was equivalent to that of the Product ‘B' · Complete safety and stability verification as bonegraft · Excellent biocompatibility,...

Pre-clinical case Space maintenance test (Micro CT) : Small Animal (Rat) · Superior space provision after 4 and 8 weeks in defect when compared to product 'B' New bone formation test (H&E Stain) : Large Animal (15 Dogs, Beagle) After 4 weeks Newly formed bone (%) Newly formed bone (%)

Case 1 Preoperative X-ray Incision of the affected part Fixture placement Postoperative X-ray Application of CGF Membrane Temporary Prosthesis Fixture placement Preoperative X-ray Postoperative X-ray After 3 months 2nd Surgery X-ray After 2nd Surgery (Detection of keratinized tissues) (Successful Bone formation) ■ M. Figueiredo et al., 2010, Effect of the calcination temperature on the composition and microstructure of hydroxyapatite derived from human and animal bone, Ceramics International 36 (2010) 2383-2393 ■ AntoR Murugan et al., 2002, Heat-deproteinated xenogeneic bone from slaughterhouse...