PORCINE BONEGRAFT NATURAL BONE SUBSTITUTE

Manufactured by /1/lGdPafk PORCINE BONEGRAFT . ggBBH Original technology which has been passed clinical test (3rd phase) Sepcifications High blood permeability, similar pH to body fluids, rapid new bone formation without inflammatory reactions Sticky bone formation through PRF and CGF with independent process technology Selection of proper size of graft materials for suitable environment for bone regeneration Increased micropores allows the migration of osteoblasts for increasing new bone formation ■ Enhanced hydrophilicity allows user to manipulate easily ■ Applicable to various indication such...

[ Osteoblasts Differentiation Test ] [ Osteoblast Attachment ] Pre-clinical case New bone formation test (H&E Stain) : Small Animal (Rat) 4 weeks weeks 10. Histologic sections ofa,b,e,f,i,j ( ) Bio-Oss8 and Figure c,d,g,h,k,l ( 10. Histologic ) Bone-XPsections groups at ofa,b,e,f,i,j 4( weeks ) Bio-Oss andc,d,g,h,k,l ( 30 ) Bone-XP groups at 4 weeks post-surgery. a,c,e,g,i,k ( ) haematoxylin and eosin (H&E) post-surgery. stained slides; a,c,e,g,i,k ( b,d,f,h,j,l) ( ) haematoxylin Masson’sand eosin (H&E) stained slides; b,d,f,h,j,l) ( Masson’s trichrome (MT) stained slides; Arrowhead: originaldefect...

• Conducting clinical trials with 19 test groups and 18 control groups through random allocation (Total 37 subjects) • 19 test groups (POSS), 18 control groups (Product 'B') • Clinical study results identification of equal abnormality with ‘B’ product Inorganic ingredients similar to human bones Phase name

Case 1 Preoperative X-ray Application of POSS Fixture placement Application of Membrane Case 2 Preoperative X-ray Fixture placement Application of POSS Application of Membrane >07 WIT 2nd Surgery after 3 months Temporary prosthesis • Jung-Wook Shin et al., 2004, In vitro study of osteogenic differentiation of bone marrow stromal cells on heat-treated porcine trabecular bone blocks, Biomaterials 25 (2004) 527 535 • Jung-Wook Shin et al., 2009, Biocompatibility Evaluation of Heat-treated Mineralized Porcine Cancellous Bone-Using animal & Clinical Study, J. of Korean Orthopaedic ResearchSociety...

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