itit Volume ImmisealDural Sealant System M EDPRIN 4 Quick gel-forming 4 Absorbable 4 Low swelling ratio A Easy application 4 Water-tight seal 4 Shorter surgery time Medprin Biotech GmbH Address: GutleutstraGe 163-167, 60327 Frankfurt Email: [email protected]

| CSF leakage prevention Immisear 11dural sealant system is an absorbable synthetic sealant, applied as an adjunct to duraplasty repair such as suturing or onlay of autologous dura or non-autologous dural substitute. The application of the Immiseal™ could prevent CSF leakage from incisions and provides a barrier to minimize dural adhesion with minimum swelling. Immiseal™ is composed of synthetic materials. Upon mixing these materials with water, electrophilic and nucleophilic reactions would occur, leading to the formation of a hydrogel. Pressure tests were performed in pre-clinical canine model...