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LIFE IS DIFFERENT WITH PRO, Evolut™ PRO System
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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 1

LIFE IS DIFFERENT WITH PRO Evolut™ PRO System

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 2

YOUR PATIENTS DESERVE A PRO The Evolut™ PRO system combines exceptional valve design and advanced sealing with an excellent safety profile.

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 3

BUILT ON A PROVEN PLATFORM. 1.7% Mortality 1.7% Stroke 11.7% Permanent Pacemaker Forrest, et al., TCT, 2017 Evolut PRO 6-month data. Supra-annular valve design Self-expanding nitinol frame

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 4

ADVANCED SEALING. Evolut PRO 30-day and 6-month Outcomes 0% Moderate or Severe PVL Forrest, et al., TCT, 2017 Evolut PRO 6-month data.

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 5

UNSURPASSED HEMODYNAMICS. Supra-annular valve design maximizes leaflet coaptation and promotes single digit gradients and large EOAs. 6.4 mmHg single digit gradients 2.0 cm2 large EOA Evolut PRO Clinical Study, 60 patients, 30-day outcomes.

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 6

CONTROL. ACCESS. CONFIDENCE. Recapture and Reposition Lowest Delivery Profile Acute Performance

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 7

GO FURTHER WITH A PRO. At Medtronic, we are committed to collaborating with TAVR Heart Teams to improve patient outcomes, expand access, and improve efficiencies. As a global leader in medical technology, services, and solutions, we’re working with others to take on the industry’s greatest challenges

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 8

INDICATIONS The Medtronic CoreValve™ Evolut™ R and CoreValve™ Evolut™ PRO systems are indicated for relief of aortic stenosis in patients with symptomatic heart disease due to severe native calcific aortic stenosis who are judged by a heart team, including a cardiac surgeon, to be at intermediate or greater risk for open surgical therapy (i.e., predicted risk of surgical mortality ≥ 3% at 30 days, based on the Society of Thoracic Surgeons (STS) risk score and other clinical comorbidities unmeasured by the STS risk calculator). The Medtronic CoreValve Evolut R and CoreValve Evolut PRO...

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LIFE IS DIFFERENT WITH PRO, Evolut™  PRO System - 9

710 Medtronic Parkway Minneapolis, MN 55432-5604 USA Tel: (763) 514-4000 Fax: (763) 514-4879 Toll-free: (800) 328-2518 LifeLine CardioVascular Technical Support Tel: (877) 526-7890 Tel: (763) 526-7890 Fax: (763) 526-7888 rs.cstechsupport@medtronic.com ©2017 Medtronic. All rights reserved. Medtronic, Medtronic logo and Further, Together are trademarks of Medtronic. TM *Third party brands are trademarks of their respective owners. All other brands are trademarks of a Medtronic company. UC201710255a EN 12/2017

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