microfluidic ChipShop Lab-on-a-Chip Catalogue Lab-on-a-Chip Catalogue 10/2019

microfluidic ChipShop The lab on the chip - miniaturized solutions as easier and faster analytical tools for the life sciences, diagnostics, analytical sciences, and chemistry are at the heart of microfluidic ChipShop's business. The company, started in 2002 as a spin-off from the Fraunhofer Institute for Applied Optics and Precision Engineering and the Application Center for Microtechnology Jena, has become a world leader in this rapidly growing technology field. Specialists from microfluidics, precision engineering, polymer microtechnology, medical technology, chemistry, biology, and diagnostics...

Miniaturized solutions for diagnostics, analytical sciences, and life sciences Miniaturization has already transformed the world of electronics and became a driver for many markets. Now it‘s a driving force for an innovation in the life sciences, diagnostics, analytical sciences, and chemistry, which is labeled “lab-on-a-chip.” The use of micro- and nano-technologies allows the development of fast, portable, and easy-to-use systems with a high level of functional integration for applications such as point-of-care diagnostics, forensics, the analysis of biomolecules, environmental or food analysis,...

microfluidic ChipShop – Our infrastructure In May 2011, microfluidic ChipShop moved into its new corporate headquarter, which was extended with a second buiding in 2015. On a space of approx. 4.700 sqm (approx. 52.000 sqft) the purpose-built facility, located in one of Jena‘s new industry parks conveniently close to the autobahn, contains all the required infrastructures for your one-stop-shopping in microfluidic development and production. The buildings are organized in four main areas: The first wing contains the precision mechanic workshops. In this area, the design and generation of molding...

For the manufacturing of polymer parts using injection molding and hot embossing, a temperature controlled clean space of approx. 400 sqm (4.300 sqft) is provided. The injection molding machines are housed in clean-room hoods in order to reduce the particle load. From this area, the parts are transported into a class 7 cleanroom area of 500 sqm (5.400 sqft) for back-end processing. In this area, processes like surface functionalization, integration of wet and dry reagents, spotting, assembly and packaging takes place. Optical measurement stations including a confocal white-light interferometer...

The Lab-on-a-Chip Catalogue – Shortcut to the world of microfluidics Offering catalogue devices and development platforms, fulfilling common laboratory standards in their dimensions and interfaces, microfluidic ChipShop allows users a quick, low-cost, and low-risk entry into the innovative field of microfluidics. The chips offered within microfluidic ChipShop‘s Lab-on-a-Chip Catalogue cover a range of applications from simple liquid handling, electrophoresis, extraction, or mixing up to sample preparation and complete analytical tasks. Please enjoy our Lab-on-a-Chip Catalogue as your roadmap...

1 microfluidic ChipShop‘s Lab-on-a-Chip Catalogue 3 Microfluidic chips – Polymers 3.1 Introduction to microfluidic chips 3.2 Straight channel chips – Microscope slide format 3.3 Straight channel chips – Microtiter-plate format 3.4 Cross-shaped channel chips 3.5 H-shaped channel chips 3.7 Waste chamber chips 3.11 Titer plates in microscopy slide format 3.12 Droplet generator chips and integrated droplet generation solutions 3.13 Meander and continuous-flow PCR chips 3.14 ample preparation chips S

Contents 3.17 Particle & cell sorting chips 96 3.20 Field-flow fractionation chips 101 3.21 Turning valve chip 102 3.22 Blister test chips 103 4 Microfluidic devices for customization and sensor integration 1 09 4.1 Open chip platforms for self-assembly 110 4.2 Self-sealing and releasable chips - slide format 112 4.3 Sensor integration chips 113 5 Microfluidic chips - Integrated chips 123 6 Microfluidic chips - Glass 133 9 Polymer substrates and foils 183 10 ChipGenie® editions - Instruments and applications 189 11 Special instruments 201 12 Pumps and pressure controllers 211

14 Application development: Assay & reagent implementation 253 15 Application notes 17 Finally – Some examples 18 One for all – A universal diagnostic platform 18.1 ne for all – A partnership with Stratos Product O Development for the Bill & Melinda Gates foundation 18.2 n continuation – The ChipGenie® edition Dx series – I The universal diagnostic platform

1 microfluidic ChipShop‘s Lab-on-a-Chip Catalogue Our mission at microfluidic ChipShop is to shrink the biological and chemical laboratory and to bring lab-on-a-chip systems into daily laboratory life. This catalogue is part of our service to make our mission happen: From off-the-shelf microfluidic chips to complete lab-on-a-chip systems, our products serve a wide range of customer needs. Whether you need a single chip or thousands, in the following pages you will find the essential components for an easy route into the world of microfluidic handling and manipulation. Be it for the first steps...

Materials in microfluidics Material matters – and a large choice of different materials is at hand ranging from a wide variety of polymers, to glass, silicon, ceramics or metals. All materials have their pros and cons, looking e.g. at cost or geometrical freedom polymers are dominating. This chapter gives guidance through the material choice. Off-the shelf devices are at hand in polymers and in glass, custom-designs can be offered in all kind of materials and material combinations.

2.1 Materials in microfluidics In microfluidics, a wide variety of materials is in use. Historically, microfluidics and the use as lab-on-a-chip for applications in life sciences or analytical sciences started with technologies being available from semiconductor industries. Consequently, since these technologies were available and allowed for microstructuring, they were used for the first microfluidic devices. Materials that were applicable to be structured by technologies used in semiconductor industries were glass and silicon. First microfluidic devices, besides ink jet printer heads for non-life...