Quantify Magnetic Resonance Image distortion for the entire 3D field of view... automatically! QUASAR™ MRID3D is a new, patent pending, cost-effective QA system for quantifying geometric distortion in 3D MR images. Analysis is performed on images for diagnostic and guidance applications. Unlike other distortion analysis products, which only sample a few imaging planes, QUASAR™ MRID3D analyzes the entire 3D field of view in a single acquisition. The system is based on a method that uses harmonic analysis to map the distortion vector field by analyzing the location of control points in images of the phantom. The results have been verified by comparison to a custom high density 3D grid phantom. A submission to Medical Physics is pending publication. The large, lightweight phantom is easy to setup in MRI scanners and comes with quick and easy-to-use image analysis software. ± Quantify, in full 3D, the geometric distortion of MR images ± Novel method based on 3D harmonic analysis of distortion ± Designed for MR image guidance and diagnostic imaging ± Large field of view (37cm diameter x 32cm long) ± Light weight phantom (<17Kg) ± System includes automated image analysis software The QUASAR™ MRID3D Phantom contains an array of mineral oil filled control points on the surface of a hollow twin walled closed acrylic cylinder that weighs less than 17 kg. The mineral oil is susceptibility matched to acrylic to minimize susceptibility artefact. The physical dimensions of the phantom are 38 cm diameter by 34 cm long – with a hollow internal volume of ~25 liters. A small insert at the center of the phantom includes an orientation cube to facilitate initial 3 plane MR Image localizing and establish a frame of reference. This central insert can be replaced with task specific objects for image guidance applications. Above: 3D comparison of control point image location (red) vs truth (green, meshed grid derived from CAD data). Distortion vector field at the phantom boundary is calculated from the difference between control point image location and truth, results are easily visualized in 3D. The QUASAR™ MRID3D software automatically identifies the location of the control points in an image of the phantom and uses proprietary algorithms based on harmonic analysis to derive a complete volumetric mapping of the distortion vector field within the phantom boundary control points. The results are shown graphically in a 3D display and numerically in a spreadsheet. The software is compatible with Window 7 or higher operating systems. Accuracy. Confidence. © 2014 Modus Medical Devices Inc. All Rights Reserved. Specifications subject to change without notice. Modus is not responsible for errors or omissions. Modus makes no warranties or commitments concerning the availability of future products or versions that may be planned or under development. PDS#100-1018, REV#09/16

Accuracy. Confidence. Above: Software GUI screenshots are taken from the QUASAR™ MRID3D Alpha release using simulated data. MINIMUM SYSTEM REQUIREMENTS ± Operating System: Windows 7 ± Processor: Intel Core™ i5, Intel Core™ i7 or later ± Hard disk space: 10 GB (64-bit) ± RAM: 8 gigabyte (GB) or more ± Screen Resolution: 1280 x 720 pixels or higher ± Graphics card: Intel HD Integrated Graphics or Nvidia GeForce GTX 750 or better MRI DATA ACQUISTION REQUIREMENTS ± ± ± ± 3D T1 weighted sequence (GE-FLASH, Philips-Fast Field Echo, SIEMENS-VIBE) with 1 NEX ~ 40 minute acquisition time @ 1.5T, ~20 minute...