SpectraMax L Microplate ReaderA flexible, sensitive luminometer for 96- and 384-well microplates BENEFITS • Detect dim samples with unsurpassed sensitivity • Avoid saturation issues with 9 orders of dynamic range • Enable robust performance with autorinse injectors • Ensure compliance with IQ/OQ and FDA CFR 21 Part 11 compliance tools • Easy set-up and analysis with industry-leading SoftMax Pro Software The SpectraMax® L Microplate Luminometer from Molecular Devices offers the sensitivity, reliability, flexibility, upgradability, automation options, and validation tools required by today’s leading laboratories. The reader is ideal for measuring flash and glow assays, including dual luciferase reporter gene, G protein-coupled receptor (GPCR) via aequorin, bioluminescence resonance energy transfer (BRET), and acridinium ester flash assays, in both 96- and 384-well plates. The SpectraMax L reader is upgradeable to dual-channel configurations for a 2-fold increase in throughput for medium throughput and secondary screening laboratories. Industry-leading SoftMax® Pro Microplate Data Acquisition and Analysis Software eliminates the need to export data to spreadsheet programs, and manages instrument control and results generation in a GxP environment. SoftMax Pro GxP Software and its software validation package provide comprehensive documentation and extensive data sets to meet FDA 21 CFR Part 11 and GxP compliance requirements. Reduced noise Ultra-fast photon counting technology amplifies the PMT signal with a fast pulse amplifier. This reduced noise capability enables a higher signal-to-noise ratio and the lowest crosstalk in laboratory assays. Nine orders of dynamic range The simultaneous analog and photon counting capability provides a dynamic range of more than nine orders of magnitude, eliminating the need to dilute bright samples while maintaining excellent sensitivity for dim samples. Up to 2-times faster The SpectraMax L reader is available in 1- and 2-channel (Photomultiplier Tube) configurations. The 2-channel configuration is available with 0, 2, or 4 injectors. The 4 injector configuration enables flash and glow BRET assays and a 2-fold improvement in speed for traditional flash and glow assays.

The 2-injector configuration enables flash and glow BRET assays, a 2-fold increase in speed for traditional glow assays, and normal speed for traditional flash assays. The 0-injector configuration enables BRET assays and a 2-fold increase in speed for traditional glow assays. Automatic and manual PMT calibration The SpectraMax L reader offers two methods to correct inherent PMT spectral response variability in multi-channel configurations. The automatic PMT calibration method is based on readings of 4 internal LEDs at 395, 470, 527, and 570 nm. The manual PMT calibration method is based on readings...