Beta Cell Screening

Beta Cell Screening

Beta Cell Screening

Product catalog summary
Introduction
This document provides an overview of the use of in vitro electrophysiology for diabetes research, focusing on a MEA-based parallelized screening system for intact islets of Langerhans. It highlights two configurations for either long-term, incubator-ready chronic or non-invasive acute recordings.
Specifications
The MCS-IFB 3.0 multiboot interface board supports a range of MCS in vitro and in vivo headstages, allowing cost-effective adaptation to various lab needs. The MEA2100-Beta-Screen-System facilitates non-invasive, fast electrophysiological recordings of up to 40 islets simultaneously, with beta cell-specific analysis software included. The MEA2100-Mini-System is designed for chronic recordings, offering a small footprint and low heat emission, suitable for continuous recordings in an incubator.
Procedures
Acute recordings are performed using the MEA2100-Beta-Screen-System, which is easy to use and allows for medium throughput screening. Chronic recordings are conducted with the MEA2100-Mini-System, ideal for undisturbed recordings and stimulation of samples in controlled environments.
Software
The Beta-Screen software is tailored for long-term and acute beta cell recordings, providing tools for spike/burst analysis and dose response experiments on pancreatic beta cells.
Applications
Electrophysiological recordings of multiple islets of Langerhans are crucial for diabetes research, particularly in understanding glucose-dependent electrical oscillatory activity in beta cells. This technology supports drug development for type 2 diabetes mellitus and elucidates beta cell pathophysiology.
Advantages
The MEA technology offers a non-invasive method for long-term in vitro research, with simpler handling and higher throughput than conventional methods. It is suitable for diabetes research and drug development, providing measurements from intact islets.
Conclusion
MEA-based parallelized screening systems offer significant advantages for diabetes research, enabling detailed study of beta cell physiology and pathophysiology, and supporting the development of new therapeutic drugs.
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Catalog excerpts

Beta Cell Screening-1

recordings of up to 40 islets simultaneously • Non-invasive and fast, medium throughput screening device Beta cell specific analysis software included Islets secured using suction Drug screening also possible with human beta cells Chronic recordings with incubator-ready system MEA2100-Mini-System • Small footprint, low heat emission Possibility for parallel operation of many headstages Ideal solution for continuous, undisturbed recordings and stimulation of samples in the incubator or on a microscope stage with environmental control specifically designed for long-term and acute beta cell recordings. It is a specialized tool set for spike/ burst (oscillation) analysis and dose response experiments on pancreatic beta cells in islets of Langerhans. Interface board multiboot Beta Cell Screening The MCS-IFB 3.0 multiboot is a new generation of interface board, which enables you to operate a wide range of MCS in vitro and in vivo headstages: MEA2100-HS, MEA2100-Mini-HS, MEA2100- Acute and chronic recordings of glucose induced electrical activity in pancreatic beta cells Beta-Screen-HS, Multiwell-MEA-HS, CMOS-MEA-HS, W2100-RE, and ME2100-HS. This allows you to cost-effectively adapt the system to your lab’s needs by pairing only one interface board with multiple recording systems. • In vitro electrophysiology for diabetes research ation visit: ore inform For m en.com .beta-scre www • MEA-based parallelized screening system for intact islets of Langerhans Multi Channel Systems MCS GmbH © April 2018 Multi Channel Systems MCS GmbH Product information is subject to change without notice. Products that are referred to in this document may be either trademarks and/ or registered trademarks of the respective owners. The publisher and the author make no claim to these trademarks. Aspenhaustrasse 21 72770 Reutlingen Germany Phone Fax [email protected] www.multichannelsystems.com • Two configurations for either long-term, incubatorready chronic or non-inv

 Open the catalog to page 1
Beta Cell Screening-2

MEA-based parallelized screening of islets of Langerhans Glucose-dependent electrical oscillatory activity in beta cells within diabetes research on beta cells. Electrophysiological recordings of multiple islets of Langerhans for islets of Langerhans is important for understanding their physiology and pathophysiology. Electrophysiological recordings are both time consuming and technically challenging thus limiting academic research and industrial drug development. We offer MEA-based parallelized recording systems for multiple acute recordings on primary or stem cell derived islets of Langerhans...

 Open the catalog to page 2
Beta Cell Screening-3

MEA-based parallelized screening of islets of Langerhans Glucose-dependent electrical oscillatory activity in beta cells within diabetes research on beta cells. Electrophysiological recordings of multiple islets of Langerhans for islets of Langerhans is important for understanding their physiology and pathophysiology. Electrophysiological recordings are both time consuming and technically challenging thus limiting academic research and industrial drug development. We offer MEA-based parallelized recording systems for multiple acute recordings on primary or stem cell derived islets of Langerhans...

 Open the catalog to page 3
Beta Cell Screening-4

recordings of up to 40 islets simultaneously • Non-invasive and fast, medium throughput screening device Beta cell specific analysis software included Islets secured using suction Drug screening also possible with human beta cells Chronic recordings with incubator-ready system MEA2100-Mini-System • Small footprint, low heat emission Possibility for parallel operation of many headstages Ideal solution for continuous, undisturbed recordings and stimulation of samples in the incubator or on a microscope stage with environmental control specifically designed for long-term and acute beta cell recordings....

 Open the catalog to page 4
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