Powerful analysis software CMOS-MEA-Tools Offline analysis of CMOS data can be done in the program CMOSMEA-Tools. Results can be exported in ASCII or HDF5 format to other applications. General characteristics Dimensions (W x D x H) multiple filtering options, as well as spike detection, spike triggered average movies, and fully automated spike sorting. Amplifier Data resolution Number of recording channels Stimulus generator Number of stimulation patterns Activity summary Filter pipeline The one-click activity summary generates a A filter pipeline can be assembled from a number of spatial Signal shapes Freely programmable (monophasic, biphasic, bursts, sinusoidal) or Ground temporal and spatial overview of the activity and temporal filters to optimize signal quality before spike in the file and allows easy navigation to the Output voltage interesting times and areas. 3.4 V amplitude with 10 µs rise time for high capacitive currents Data converter and USB interface Control interface Sampling rate per channel Heating element and temperature sensor Heating element impedance Spike detection and sorting Temperature sensor type PT 100 with 4 wire connection CMOS-MEA-Tools features a fully automated spike sorting. The spike sorting algorithm implemented in the software is based on the work published in Leibig et al., J.Neurosci. Operating system Meth., 2016. It allows unsupervised identification of English and German versions supported CMOS-MEA-Control software CMOS-MEA-Tools software Data format Data acquisition neuronal units with a single mouse click. A client software allows to run performance intensive sorting tasks on several computers in a network simultaneously. Spike triggered average movies Spike triggered averages allow to detect • Active microelectrode arrays for recording and stimulation repetitive events correlated to each spike on a specific electrode, like axonal signals, which are usually hidden in the noise. The travelling axonal signals can be visualized and exported as a movie. Extracellular recordings and stimulation at the highest resolution logy visit: ctrophysio ions for ele te solut For comple hys.com .smart-ep www Developed in cooperation with Prof. Roland Thewes, TU Berlin, and Dr. Günther Zeck, Natural and Medical Sciences Institute (NMI), Reutlingen, Germany © February 2019 Multi Channel Systems MCS GmbH Product information is subject to change without notice. Products that are referred to in this document may be either trademarks and/or registered trademarks of the respective owners. The publisher and the author make no claim to these trademarks. • 4,225 recording and 1,024 stimulation sites • Outstanding signal quality Multi Channel Systems MCS GmbH • Recordings at sub-cellular level Aspenhaustrasse 21 72770 Reutlingen Germany • Powerful recording and analysis software

Highest resolution with active arrays Recording electrode Based on the complementary metal-oxide semiconductor technology, the CMOS- Stimulation site MEA5000-System from Multi Channel Systems opens up new possibilities in electrophysiological research. With more than 4,000 recording sites, each of them sampled at 25 kHz, the chip allows extracellular recordings at a very high spatio-temporal resolution. By including amplification on the chip itself, noise is minimized and a high signal quality is guaranteed. As stimulation sites are included in the chip and a stimulus generator in the headstage,...

Highest resolution with active arrays Recording electrode Based on the complementary metal-oxide semiconductor technology, the CMOS- Stimulation site MEA5000-System from Multi Channel Systems opens up new possibilities in electrophysiological research. With more than 4,000 recording sites, each of them sampled at 25 kHz, the chip allows extracellular recordings at a very high spatio-temporal resolution. By including amplification on the chip itself, noise is minimized and a high signal quality is guaranteed. As stimulation sites are included in the chip and a stimulus generator in the headstage,...

Highest resolution with active arrays Recording electrode Based on the complementary metal-oxide semiconductor technology, the CMOS- Stimulation site MEA5000-System from Multi Channel Systems opens up new possibilities in electrophysiological research. With more than 4,000 recording sites, each of them sampled at 25 kHz, the chip allows extracellular recordings at a very high spatio-temporal resolution. By including amplification on the chip itself, noise is minimized and a high signal quality is guaranteed. As stimulation sites are included in the chip and a stimulus generator in the headstage,...

Powerful analysis software CMOS-MEA-Tools Offline analysis of CMOS data can be done in the program CMOSMEA-Tools. Results can be exported in ASCII or HDF5 format to other applications. General characteristics Dimensions (W x D x H) multiple filtering options, as well as spike detection, spike triggered average movies, and fully automated spike sorting. Amplifier Data resolution Number of recording channels Stimulus generator Number of stimulation patterns Activity summary Filter pipeline The one-click activity summary generates a A filter pipeline can be assembled from a number of spatial Signal...

Powerful analysis software CMOS-MEA-Tools Offline analysis of CMOS data can be done in the program CMOSMEA-Tools. Results can be exported in ASCII or HDF5 format to other applications. General characteristics Dimensions (W x D x H) multiple filtering options, as well as spike detection, spike triggered average movies, and fully automated spike sorting. Amplifier Data resolution Number of recording channels Stimulus generator Number of stimulation patterns Activity summary Filter pipeline The one-click activity summary generates a A filter pipeline can be assembled from a number of spatial Signal...