CE96
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The CardioExcyte 96. Contractility. Electrophysiology. Viability.

CardioExcyte 96 Label-free cardiac safety screening The CardioExcyte 96 is a hybrid device supporting highly cell viability monitoring. It has a small footprint and performs fully automated recordings from 96 wells in parallel. With embedded control electronics and sophisticated sensor technology, the CardioExcyte 96 screening and long-term monitoring of cell viability. The CardioExcyte 96 has been validated with stem cell-derived cardiomyocytes from several providers Different concentrations of compounds induced effects on beat rate, amplitude, beat irregularity in Cor.4U cells (NCardia,...

. Versatile data analysis & data handling. The CardioExcyte 96 control software supports online software package is an independent software package to load and analyze data recorded Function automatically visualizes the average of beat on the CardioExcyte 96 or FLEXcyte 96. Customized traces from one well, enveloped by the standard export formats of analysis results are integrated. deviation, indicating the consistency of the beat pattern Supporting standardized processes, analysis templates within the recording well, i.e. if the cellular network is can be saved and re-loaded. Normalization...

96-well live view showing dynamic impedance and impedance baseline. Averaged trace: Single-well detailed view allowing zoom in 16-well group view: mean beat traces and trace selection, here showing mean (and SD in red) from selected wells. beat signals. Red traces show the standard deviation from the mean. time Cellular monolayer Standard 96-well plate format optional stimulation electrode and Planar, bipolar circular gold electrodes Supports recordings from 2D and 3D structures Hybrid sensor design for both EFP and impedance recordings transparent substrates ) ZCM ZE Sensing & reference...

CardioExcyte 96 Imp: 1-10 ms, 0-500 Hz / EFP: 0.1-1ms, 0.1Hz-5kHz 0.1-100 kHz multi-sensor temperature control Cor.4U®, iCell® , Cytiva , Cor.At® 96 integrated Incubation System electrical and optical (optional) standard plates; stimulation plates; transparent plates The CardioExcyte 96 bridges the gap between in vivo cardiotoxicity compound screening by offering relevant means for in vitro recordings from intact, synchronously beating networks of cardiomyocytes. Altered beating patterns give an indication of what ion channel is affected potentials. contractility investigations from a...

Smart tools for ion channel research “We are happy to have acquired the CardioExcyte 96 from Nanion and look forward to publishing the first of many papers. We looked at several different devices on the market but were impressed by the resolution and ease-of-use of the CardioExcyte 96 and Nanion’s enthusiasm and friendly customer support. I was particularly intrigued by the pacing feature, the single electrode design giving better signal to noise ratio, the dual EFP + impedance capability, and the environmental chamber so that you can run everything on the benchtop. The new optical pacing...