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Maturation of iPSC-CM

Maturation of iPSC-CM
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CardioExcyte 96 continuous pacing • Full control of beating rate • 96 channel electrical pacing • Continuous pacing induces further maturation of iPSC-CM • Improved responses to inotropic compounds in mature iPSC-CM Functional maturation of iPSC - CM by pacing with CardioExcyte 96 Electrical pacing and combined investigation of contractility, extracellular ﬁeld potentials and viability. The CardioExcyte 96 device supports highly resolved impedance-based contractility measurements, MEAlike extracellular ﬁeld potential (EFP) and viability recordings. It has a small footprint and allows for automated recordings from 96 wells in parallel. The beneﬁt of iPSC-CM (induced pluripotent stem cell -derived cardiomyocytes) due to their predictive power Fined-tuned user interface. Pace rate, Pulsewidth and Intensity settings can be deﬁned. Electrode design of 96-well stimulation plates with recording (Rec), reference (Ref) and stimulation (stim) electrode. in drug safety assays is well established. There are however challenges to overcome due to relative immaturity of the cells, before the cells can be utilized as an all-round predictive model for drug safety assays. Pacing at physiological heart rates can improve paced functionality of iPSC-CM and responses to inotropic compounds. The CardioExcyte 96 allows for two independent pacing options. Electrical pacing via stimulus electrode or the stimulating optical lid, CardioExcyte 96 SOL, which uses Extracellular ﬁeld potentials in paced and non-paced iPSC-CM. LEDs for spatially uniform stimulation of cells transfected with light-gated ion channels such as Channelrhodopsin2 (ChR2). Nanion Technologies info@nanion.de Phone: +49 89 2 190 95072 www.nanion.de

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