SyncroPatch® 384PE. Patch clamp finally goes HTS. Smart tools for ion channel research SyncroPatch® 384PE Technical Specifications: average whole cell-stability successful whole-cell recordings seal resistance series resistance chip resistance ~3 MΩ (different ranges available) perfusion time constant minimum exposure time compatible liquid handling robots Biomek FX (Beckman-Coulter), CyBi-FeliX (CyBio) amplifier channels HTS screening of stem cell-derived cardiomyocytes ‘The SyncroPatch® 384PE is a landmark in the history of automated patch clamping. It follows a completely revolutionary concept: a truly ­ odular m and HTS-capable automated patch clamp device that will integrate into your existing or planned screening process line, rather than being a closed, stand-alone system. No other platform on the market is c ­ apable of recording 384 to 768 cells in parallel, let alone with ­ iga-seals. g In development, we have carefully listened to key customers from i ­ndustrial pharma high throughput screening laboratories to fulfil their requirements of HTS-settings. We are extremely excited and ­ nthusiastic e about our new platform, and so are the first customers who recently invested in several SyncroPatch® 384/768PE instruments.’ Benefit from our experience The SyncroPatch 384PE is based on proven, successful technology and more than 10 years’ experience in d ­ evelopment of automated patch clamp (APC) s ­ ystems. Recordings are stable and success rates are high (>85%) for diverse cells and targets. Assay d ­ evelopment Niels Fertig, CEO and founder of Nanion Technologies, Munich Germany a ­ daptable from other APC platforms, also for special applications such as stem cell-derived ­ ardiomyocytes. c Nanion works closely together with Beckman-Coulter Approximately 300 stem cell-derived cardiomyocytes are required for a swift and seamless integration into your ­ TS H per recording well (Cor.4U, Axiogenesis). Just 1.5 million stem cells f ­ acilities, and to promptly respond to ­ ustomer c r ­equest. Contact us for the Formula 1 experience of ion ­ hannel c screening – schedule your demo today! The SyncroPatch® 384PE includes: • Biomek FX with a 384-pipettor arm and gripper • 1-2 Patch Engine Modules • 1-2 amplifiers (384-channels) • atchControl® 384 and P DataControl® 384 software suite Nanion Technologies Medi Analytika India Pvt. Ltd Bronjo Medi 6, Adyar Bridge road p ­ ipettor arm, automatically picking up the Screen 100% of the compounds! The ­ All-Compounds-Screened’ ­unction (ACS) ‘ f compounds of those wells which did not • Temperature-controlled cell hotel match the set quality criteria. It places them in • Barcode scanner • NPC®-384 borosilicate recording plates c ­ ompounds is automatically scheduled on a Nanion Technologies China Quantum Design Korea Sunpoint Scientific Instrument Room 337, Building 6, Yard No.1 517-18 Kyungbin Bldg. 4F, Dogok-dong • ptional 8-channel pipetting head O for ACS function later occasion. The ACS function keeps Kangnam-gu, Seoul r ­edundancy at a minimum and increases the Haidian District, Beijing, 100085 China

SyncroPatch® 384PE. Patch clamp finally goes HTS. 420mm Gesamt 628 SyncroPatch® 384PE Technical Specifications: • 84 – 768 cells in parallel 3 (modular approach) • 5% success rates 8 (completed recordings) • Giga-seal recordings • eliable data from diverse R ion channel targets average whole cell-stability successful whole-cell recordings seal resistance series resistance <1 s Biomek FX (Beckman-Coulter), CyBi-FeliX (CyBio) 384 or 768 Fully HTS-compatible automated patch clamp minimum exposure time • ingle- and multi-hole S recording substrates ~3 MΩ (different ranges available) perfusion time...

SyncroPatch® 384PE. Patch clamp finally goes HTS. DataControl® 384 software suite. Efficient data handling and export. PatchControl® 384 • 20,000 data points per day • Cost-efficient high throughput screening the overview on the right, the recording wells are i ­nformation, and quality control parameters are v ­ isualized and color-coded based on ­ ser-defined u e ­ xported together in a user-defined export format, automatically generating pdf-reports, and preparing and capacitance. With one mouse click, the view the data for further database integration. This process s ­ witches to online analysis...

SyncroPatch® 384PE. Patch clamp finally goes HTS. Smart tools for ion channel research SyncroPatch® 384PE Technical Specifications: average whole cell-stability successful whole-cell recordings seal resistance series resistance chip resistance ~3 MΩ (different ranges available) perfusion time constant minimum exposure time compatible liquid handling robots Biomek FX (Beckman-Coulter), CyBi-FeliX (CyBio) amplifier channels HTS screening of stem cell-derived cardiomyocytes ‘The SyncroPatch® 384PE is a landmark in the history of automated patch clamping. It follows a completely revolutionary concept:...