neuroConn closed-loop solutions for researchers The simultaneous application of non-invasive brain stimulation (NIBS) and EEG has significantly advanced our comprehension of NIBS-induced local and network effects, as well as the functional role of brain oscillations. The manipulation of individual parameters, such as intensity, frequency, and phase, can influence the outcomes of NIBS. State-dependent NIBS allows researchers to precisely control these parameters and influence brain activity with high temporal and spectral precision. neuroConn LOOP-IT This hardware platform is perfect for realtime data acquisition, analysis, and the control of neuro-modulatory stimulation. It enables state-dependent and closed-loop controlled experiments, Temporal Interferance stimulation and neuromuscular stimulation - all simultaneously and synchronously and within one box. LOOP-IT ensures minimized constant delays between data acquisition, analysis, event detection, and derived parameters for the output module (e. g., tES or FES current source, trigger of TMS). Functioning as a multi-channel stimulator for 2 or 4 transcranial and/or peripheral stimulations, our current sources exhibit low noise, high temporal precision, and galvanic isolation. This setup is specifically designed for temporal interference stimulation as well as pairing transcranial and neuromuscular stimulation, providing a comprehensive solution for advanced neuroscience research. neurocare group AG Albert-Einstein-Str. 3 | 98693 Ilmenau | Germany T +49 3677 68 9790 [email protected] www.neurocaregroup.com

• galvanically isolated modules with different functionality: • EEG / ECG / EMG biosignal acquisition (up to 1 ksps) • tDCS / tACS / tRNS current sources (low 1/f noise, < 5 mApp, < 5 kHz bandwidth) • neuromuscular electrical stimulation (NMES) (< 200 kHz, full scale rise time: 1 ps; high-power (+/- 40 mA) and high speed application up to 1 ms duration in constant current applications (+/- 15 mA) • multichannel digital I/O (TMS, event-related potentials) • sensor interface for non-electrical biosignals (e. g. movement, breathing, blood flow, temperature) • based on a real-time data processing...