Introducing: NeuroSENSE® Monitor With WAVCNS Bilateral Indices Because monitoring

Our Mission Develop, manufacture, and market patient monitoring NeuroWave is proud to introduce the NeuroSENSE® NS-701 products using advanced Monitor - the next generation brain function monitor for assessing signal processing of brain the adequacy of anesthesia and sedation in the operating room, waves for Neurology, Critical Care, Anesthesia intensive care unit, and emergency room. The system offers clinicians a quantitative guide to aid in better titration of anesthetic or sedative drugs according to patient-specific needs. and Emergency Medicine clinical applications, to Powered by leading-edge...

Known Benefits of Brain Function Monitoring Accurate patient-specific drug administration allows for adequate anesthesia/sedation and may lead to the following benefits: • Improved outcomes — patients can: – Wake up faster and more predictably – Recover faster and be eligible for earlier discharge – Have decreased post-surgical nausea and vomiting • Reduced likelihood of excessive depth of • Reduced drug consumption and associated costs Clinical quality EEG provides the user with continuous information about the patient’s brain function to guide clinical decisions a

NeuroSENSE® Product Patented delay-free tracking of patient state via low-noise WAVCNS bilateral indices [1] • WAVCNS (Wavelet Anesthetic Value for Central Nervous System) activity. It acquires and displays two frontal EEG signals, and calculates a indices react instantaneously to changes in patient state • Automatic trending facilitates immediate response without increasing the index noise bilateral WAVCNS indices — wavelet-based quantifiers of brain activity. True bilateral monitoring with great inter-hemispheric • Increased reliability due to redundancy – Pronounced asymmetry between indices...

Superior discrimination between consciousness and • Accurately determines patient state to support clinical decision Linear response to increasing EEG suppression [4] • More accurate quantification of deeper anesthetic states Compliant with the guidelines of International Federation of Clinical Neurophysiology (IFCN) and American Clinical Neurophysiology Society (ACNS) • High-resolution clinical EEG tracings suitable for interpretation and processed data trends • Accessible during both live case monitoring and archived electrodes require only minor patient preparation, and are affordably priced....

NeuroSENSE® Clinical Guidelines The recommended WAVCNS range for general anesthesia is between 40 and 60 as within this range there is a very low probability of a patient being either awake or in a deep anesthetic state as characterized by the presence of burst suppression [5]. In the absence of unilateral brain pathology and with good signal quality, the level of agreement between the WAVCNS bilateral indices for the left and right cerebral hemispheres is typically within ±8 units with Increasing probability Low probability of burst suppression Increasing probability ► Published and biologically...

NeuroSENSE® Technical 2 EEG channels (4 electrodes) for bilateral monitoring Display Specifications: Processed Variables (per hemisphere): – WAVCNS index (Wavelet-based Anesthetic Value for Central Nervous System) – 10.4" resistive touch screen – Simple pole mount – Electrode-skin contact impedances Touch screen interface – Signal quality indicators Protected against water ingress (IPX3) – Density spectral array, Spectral powers, MEF, SEF Archived Data: Sampling Frequency: 900 S/s per channel – File Format: EDF+ Device Connectivity: Continuous measurement of electrode-skin contac

HARNESSING THE POWER OF EEG For more information, visitwww.neurowavesystems.com NeuroSENSE® is compliant with the following standards/regulations for medical devices: Available for Sale in Canada, Europe and other markets where CE Mark is recognized ^