HCA

HCA

HCA

Product catalog summary
Overview: Nikon's High Content Microscope System integrates the Eclipse Ti inverted microscope with NIS-Elements HC Software, offering a comprehensive solution for high content acquisition and analysis. This system is designed to support both small-scale discovery experiments and large-scale screening assays without requiring adjustments to focusing methods, wavelengths, filters, or camera settings.
Key Features:
  • Scalability: The system supports both initial discovery phases and high-volume assay runs on the same platform, minimizing setup time and variability.
  • Flexibility: Offers a wide range of hardware choices, including optics, light sources, and detectors, allowing customization for various applications.
  • Integration: NIS-Elements HC interface coordinates high-performance components, facilitating experimental design and data collection.
  • Usability: New software tools enhance the microscope's capabilities, making high content screening more accessible.
System Components:
  • Microscope: Motorized inverted microscope ECLIPSE Ti-E.
  • Image Acquisition: Multichannel, time-lapse, and multidimensional imaging with a speed of 2 minutes per 96-well plate.
  • Data Visualization: Includes plate view, sample labeling, and heat maps for trend detection.
  • Optional Modules: High-speed piezo Z-objective positioner and automatic plate loader.
Applications:
  • Live Cell Imaging: Useful for monitoring and analyzing cell-mediated assays.
  • 2D/3D Imaging: Supports novel 3D culturing methods and bioengineered matrices.
  • Stem Cell Screening: Assesses heterogeneity in cultures through large field of view images.
  • Microfluidics: Custom culturing formats for new imaging assays.
  • Functional Assays: Capture and analyze calcium ion flux events.
Conclusion: Nikon's High Content Microscope System is a versatile and scalable solution for high content analysis, integrating advanced imaging technologies with powerful software to enhance experimental workflows and data analysis.
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Catalog excerpts

HCA-1

HCA High Content Analysis System Acquire Visualize Analyze Database

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HCA-2

Nikon’s High Content Microscope System pairs the Eclipse Ti inverted microscope with NIS-Elements HC Software to provide a dedicated interface for high content acquisition and analysis routines. Wi pw\« Job Run Treatment 15 vs Treatment 23 info Performance From early discoveries to scaled up assays all on one system. Imagine one scalable imaging station that performs small scale discovery experiments and functions as the workhorse for large scale screening assays without the need to adjust focusing method, wavelengths, filters and camera settings. Break away from the restrictions of inflexible...

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HCA-3

Interchangeable hardware components extend imaging possibilities and experimental assay design options. Flexibility The ultimate spectrum of hardware choices from optics to light sources to detectors. Acquisition routines can be tailored to address any application. Scalability Facilitating initial discovery phase and high volume assay runs on the same familiar platform minimizes set up time and variability. Usability / Accessibility Fast device triggering all controlled by NIS-Elements New software tools for high content screening are software. No single component compromises speed. easy-to-operate...

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HCA-4

Well Plates Intuitive Workflow Image Analysis Plates Handling Light Source NIS-Elements HC Imaging Software Robotic Plate Loader High Content Analysis Confocal CFI60 Infinity Optics Perfect Focus P6RF6CT Built on an Eclipse Ti inverted microscope with Perfect Focus, Nikon’s High Content Microscope System provides a dedicated interface for acquisition and image analysis routines. Interchangeable options for high-speed piezo-based 3D imaging, plate handling, light sources, fast wavelength switching as well as the full range of NIS-Elements supported camera models are offered to extend the imaging...

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HCA-5

Fully integrated NIS-Elements High Content (HC) software offers streamlined HCA workflow & real-time analysis feedback. Better Workflows. Greater Efficiencies. Generating and reviewing data is the focus of the Nikon High Content platform. The software’s streamlined navigation enables easy experimental set up and advanced automation functions allow acquisition of more data points. Useful layouts provide an instant view and monitor building data with heat maps and analysis results. Automate the delivery of up to 20 plates to the imaging station. Use the same platform for a small-scale experiment...

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HCA-6

Intelligent Acquisition Intelligent Acquisition combines all aspects of performing an imaging assay or experiment, including designing custom acquisition routines and advanced image analysis procedures. A breakthrough technology, researchers can now embed real-time image analysis steps as variables to automatically adapt the acquisition protocol based on calculated results. A complete experimental design can be tailored to include sample labeling while visualization tools provide a new user experience for viewing quantitated data presented in well plate form. Plate View is the centralized location...

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HCA-7

Multiple peripheral device options enable users to customize a high content analysis system perfectly suited for their applications and future projects. Live Cell, Kinetic Time-Lapse Imaging the same cells over time provides a method for cellular characterization useful for monitoring and analyzing cell mediated killing assays for new immunotherapy models. Lab-on-a-Chip Microfluidics Designing custom culturing formats enables imaging bioengineered substrates or perfusion chambers and opens the possibility for new imaging assays. 2D / 3D Imaging Tools for 2D and 3D volume measurement, tracking...

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HCA-8

■ Specifications High Content Analysis System ■ Optional Hardware Module High-Speed Piezo Z-objective Positioner Z travel range Automatic Plate Loader N.B. Export of the products* in this brochure is controlled under the Japanese Foreign Exchange and Foreign Trade Law. Appropriate export procedure shall be required in case of export from Japan. *Products: Hardware and its technical information (including software) Number of well plates TO ENSURE CORRECT USAGE, READ THE CORRESPONDING MANUALS CAREFULLY BEFORE USING YOUR EQUIPMENT. Page 7 (Application Focus) Image Credits gg Photo of CellASIC® ONIX...

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All Nikon Instruments catalogs and technical brochures

  1. DS-Fi3

    16  Pages

  2. TI-E

    32  Pages

  3. ECLIPSE TS2

    8  Pages

  4. ECLIPSE TS2R

    8  Pages

  5. N-SIME

    6  Pages

  6. N-SIM N-STORM

    24  Pages

  7. ECLIPSE Ti2

    24  Pages

  8. Eclipse Ti

    32  Pages

  9. C2 Plus

    16  Pages

  10. SMZ18

    16  Pages

  11. N-SIM E

    4  Pages

*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.