All-on-4® treatment concept Scientific evidence © Nobel Biocare Services AG, 2019. All rights reserved. Nobel Biocare, the Nobel Biocare logotype and all other trademarks are, if nothing else is stated or is evident from the context in a certain case, trademarks of Nobel Biocare. Please refer to nobelbiocare.com/trademarks for more information. Product images are not necessarily to scale. Disclaimer: Some products may not be regulatory cleared/released for sale in all markets. Please contact the local Nobel Biocare sales office for current product assortment and availability. For prescription use only. Caution: Federal (United States) law restricts this device to sale by or on the order of a licensed dentist. See Instructions for Use for full prescribing information, including indications, contraindications, warnings and precautions. GMT 60409

The All-on-4® treatment concept – Long track record and extensive experience − Up to 7.5 years mean follow-up in the mandible and 7.0 years mean follow-up in the maxilla.1,2 − Excellent mean implant survival of 98% in 38* studies with a mean follow-up of 1–7.5 years.3 − Optimized use of existing bone and maximized anterior– posterior spread of the implants.4-7 − The scientifically proven treatment concept with tilted implants for full-arch cases.8-10 − No significant differences in crestal bone-level changes around axial versus tilted implants (p≤0.05).9 TiUnite-surface implants Continuously...

The solution proven to benefit patients and your practice − High patient satisfaction, with phonetic, masticatory and esthetic outcomes at one year being rated excellent or very good by up to 78%, 91% and 83% of patients, respectively.1,2 − Substantially reduced time and cost in comparison to alternative full-arch rehabilitation reported in a study in the USA.3 satisfied with their new teeth.3 recommend this treatment.4 74% extremely satisfied definitely recommended − Multi-unit Abutment Plus with snap functionality is designed to reduce the time needed for chairside denture conversion or creation...

100% survival and excellent bone maintenance with NobelActive® implants supporting the All-on-4® treatment concept − 100% survival at 3-year follow-up of NobelActive implants supporting All-on-4® treatment concept. − The mean marginal bone-level change at last follow-up (from implant insertion) was −0.02 mm ± 0.90 mm. Patients with bone gain or no bone − The excellent bone response was independent of the jaw (maxillary and mandibular) or implant orientation (axial and tilted). 33.3% − 100% of patients had healthy peri-implant mucosa. Patients with < −1.0 mm bone remodeling − No adverse events...

Patient cooperation is key for treatment success - The All-on-4® treatment concept with immediately loaded NobelActive implants is a predictable restorative solution for the maxilla and mandible. - Implant survival rate at two years follow-up was 99.1% in maxilla and 100% in mandible. - One set of four implants in a single non-compliant1 patient failed. - The author concludes that “patient compliance regarding diet, hygiene, and recall appointments is essential for treatment success.” ffttlttflfttltlf ffffftftftftftft ffffftftftftftft ffffffffffffffff ffffftftftftftft ♦♦♦♦♦♦♦♦♦♦♦♦♦♦♦♦ 1 non-compliant...

References − Agliardi E, et al. Immediate loading of full-arch fixed prostheses supported by axial and tilted implants for the treatment of edentulous atrophic mandibles. Quintessence Int 2010;41(4):285-293. − Babbush CA. Post-treatment quantification of patient experiences with full-arch implant treatment using a modification of the OHIP-14 questionnaire. J Oral Implantol 2012;38(3):251-260. − Babbush CA, et al. Patient-related and financial outcomes analysis of conventional full-arch rehabilitation versus the All-on-4 concept: a cohort study. Implant Dent 2014;23(2):218–224. − Drago C. Frequency...