regenerative solutions creos xenogain and creos xenoprotect

A comprehensive range of regenerative solutions A reliable foundation of sufficient bone is key to improving patients’ quality of life with dental implant treatment. With creos, we offer an outstanding regenerative solutions portfolio. The creos xenogenic assortment features an extensive range of options for a wide variety of clinical indications and preferences. For your peace of mind, our creos xenogenic products are manufactured according to Medical Device Quality System Standards1, resulting in quality products that enable effective and reliable GBR and GTR procedures.2 creos xenogain creos...

creos xenoprotect Natural, resorbable and non-chemically cross-linked membrane. It’s composed of a network of interwoven, highly purified porcine collagen and elastin fibers. Three sizes Whether for larger bone augmentations or smaller periodontal defects, the optimal fit can be found without extensive trimming, limiting waste and minimizing costs for you and your patient

creos™ xenogain – the natural framework for bone formation The creos xenogain portfolio comprises an extensive range of bovine bone substitutes for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. creos xenogain bone substitute Easy handling Treat your patients with confidence –– Available in a vial, a syringe or a bowl for fast and easy application. –– Two granule sizes and a variety of ­volumes. –– Biocompatible.6 – 9 –– Unique processing methods remove bovine proteins and lipids.3,10 –– Ca/P ratio similar to human bone.3,5,11 The scaffold for successful regeneration...

1 week after implant placement “What impressed me about this product was the variety of sizes and dosage forms, each offering very good handling properties.” creos xenoprotect Dr. Bastian Wessing, Aachen (Germany) Chemically cross-linked collagen membranes Non-chemically cross-linked collagen membranes creos xenoprotect The creos xenogain bone substitute is biocompatible 6 – 9 and unique processing methods remove the bovine proteins and lipids.3,10 With a calcium phosphate ratio that reflects the composition in human bone and a low 22– 32% crystalline structure, creos xenogain is accepted by...

creos xenoprotect 20 weeks Chemically cross-linked collagen membranes Non-chemically cross-linked collagen membranes Chemically cross-linked collagen membranes Suitable framework for new bone formation creos xenogain is a non-sintered xenogenic bone substitute, characterized by 0.5 micro- and interconnected macropore structures and a large specific surface area.3,4,10 A scaffold for successful regeneration p <0.050 creos xenogain offers a suitable environment for new bone formation.3,6,7 Time (days)  ALP activity  Calcium content ALP = Alkaline phosphatase Absorbed water mass (g) Pro-collagen...

Chemically cross-linked collagen membranes creos xenoprotect (n=6) “After using the non-sintered creos xenogain 39 – 64 % bone substitute, I appreciated its handling area [%] area [%] properties and I see its high hydrophilicity as a p <0.050 biological advantage in peri-implant defect regeneration and sinus grafting.” Univ.-Prof. DDr. Werner Zechner, Vienna (Austria) 250 Preserved macro- and micropore structures3 50 0.2 Micropores support liquid uptake due to capillary forces. Mesenchymal stem cells, osteoblasts and capillaries are able 0 0 to enter macropores of a bone substitute particle....

A solid foundation for implant treatment creos xenogain acts as a slowly resorbing scaffold and maintains space for bone regeneration.7 The graft integrates with the newly formed bone, building a basis for successful implant placement. New bone formation visible nine months after grafting procedure in the sinus 7 G: graft NB: new bone CT: connective tissue OT: osteoid Human histology based on undecalcified sample taken with a trephine bur in the posterior maxilla prior to implant insertion. Embedded in formalin solution, multiple staining, photographed with optical microscope. ­

creos™ xenogain collagen Clinical case Right upper first premolar of a 60-year-old male patient is regeneration of the bony defect and re-establish necessary bone extracted due to chronic periodontitis. One month after volume for implant placement. After nine months of uneventful extraction, GBR surgery with a creos xenogain collagen block healing, a dental implant is placed in an optimized position in the and a resorbable collagen membrane is performed to support the regenerated bone. Radiographic view before surgery. Extraction socket when raising the flap. Grafting using creos xenogain collagen...

creos™ xenoprotect – the natural barrier creos xenoprotect is a resorbable non-cross-linked collagen membrane for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. creos xenoprotect collagen membrane Outstanding handling High mechanical stability –– Easy to reposition and unfold. –– Rehydrates in seconds and adheres well to the defect shape. –– Minimal increase in size when hydrated.14 –– Outstanding mechanical strength ­properties.15 –– Resistant to stress.16 Extended barrier function –– Highly resistant to degradation for p ­ rolonged protection of the graft site.15...

“I really like the handling of this material. The fact that it does not lose all of its shape when you place it in conjunction with the tissue is a great benefit. It gives you the possibility to remove the membrane for trimming. After a minute or so, when it is soaked, it attaches very nicely to the bone.” Prof. Christer Dahlin, Gothenburg (Sweden) Lateral view showing a dense meshwork, primarily composed of highly inter­ woven collagen fibers. Magnification 482 x. (SEM image © Schupbach Ltd, ­ witzerland) S Outstanding handling properties Once moistened, creos xenoprotect does not stick to the...