creos™
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but it’s your reality THAT DRIVES US. creos™ is the Nobel Biocare regenerative product portfolio, built to meet your everyday needs. Join us and experience the carefully designed, easy-to-use, effective solutions. We aim to be the trusted regenerative partner for you and your patients, because you are what we stand for.

creos™ xenoprotect A membrane with outstanding handling that facilitates bone gain Outstanding handling1,2 ‒ Does not stick to instruments ‒ Repositioning in-situ possible ‒ Low surface expansion when hydrated ‒ Both sides can face the defect High mechanical strength2,3,4 ‒ Excellent suture retention ‒ Highly tear-resistant Enduring resistance to degradation in vivo*3 ‒ Manufacturing process intended to preserve the natural structure of the collagen fiber network, to confer a high resistance to degradation. Facilitates bone gain2,3,5,6,7,8 ‒ Excellent tissue compatibility3 “What I like is...

High mechanical strength In an in vitro study aiming to compare the mechanical strength of commonly used native non-chemically cross-linked and chemically cross-linked collagen membranes4. ‒ creos™ xenoprotect demonstrated the highest force at break, wet (21.2 N). ‒ creos™ xenoprotect had the highest suture retention, wet (6.1 N). Enduring resistance to degradation in vivo without chemical cross linking3 Manufacturing process intended to preserve the natural structure of the collagen fiber network, to confer a high resistance to degradation.3 In an animal model, after 20 weeks, the...

creos™ xenogain 3 methods of application to meet all your bone grafting needs Regenerating bone for 15 years Three different methods of application: Similar to human bone ‒ Chemical composition: Ca/P ratio ‒ Interconnected macropores9,10 Easy handling ‒ Homogenous particle size9 ‒ Hydrophilic for fast rehydration1,12 Solid foundation for dental implant treatment “I appreciated its handling properties and I see its high hydrophilicity as a biological advantage in sinus grafting and peri-implant defect regeneration” Dr. Werner Zechner, Austria ‒ Osteoconductive properties10 ‒ Long-term volume...

Scaffold for successful regeneration Preserved natural features of bone through optimized manufacturing process.10 Calcium Phosphate Ratio 2.0 1.679 Chemical composition With a calcium phosphate ratio that reflects the composition in human bone and a structure with low crystallinity. The body accepts creos™ xenogain as a suitable framework for bone formation.9 creos™ xenogain Human bone Particle size ‒ Homogenous particle size9 ‒ Maintains space for bone regeneration12 Photographic micrograph of creos™ xenogain and reference product showing the particle size distribution (magnification 20x)...

creos™ mucogain Unique oriented porous structure designed for guided soft tissue regeneration Substitutes the need for a second surgical site17,18,19 Patented manufacturing method ‒ Open interconnecting porous structure. ‒ Designed to promote soft tissue regenerationthrough the migration of cells and blood vessels into the matrix.20,21,22 Variety of choices ‒ A choice of different sizes and thicknesses. Excellent handling ‒ Easy to use23 ‒ High suture retention and stress resistance23 ‒ Memory effect after hydration and cycling loading in vitro20 “It felt like an autogenous tissue graft and...

creos™ mucogain creos™ mucogain is intended to be used for soft tissue augmentation indications in the oral cavity around teeth or implants: ‒ Guided tissue regeneration (GTR) procedures in recession defects for root coverage. ‒ Localized gingival augmentation to increase keratinized tissue around teeth and implants. Unique oriented porous structure Initial volume 1. Matrix structure Interconnecting porous structure, produced by a patented process.20,21,22 Back to initial volume 2. Mechanical properties After hydration and compression in 49 cycles in vitro, the graft regains its initial...

creos™ syntoprotect Your easy choice of dense PTFE membranes to expand grafting options syntoprotect PTFE membrane Purposely leave the membrane exposed Preservation of the soft tissue architecture and keratinized mucosa 100% dense (non-expanded) PTFE Impervious to bacteria - pore size less than 0.3 µm Soft tissue attaches, but doesn’t grow through the membrane Will not resorb prematurely you dictate healing time Exposed membrane allows for non-surgical removal; no anesthesia required syntoprotect Ti-reinforced PTFE membrane Delicate, lightweight framework Handling options Easy to trim and...

Unique properties of dense PTFE membranes Dense PTFE Expanded PTFE SEM image courtesy of Schüpbach Ltd, Switzerland. SEM image courtesy of Schüpbach Ltd, Switzerland. Dense PTFE was designed to withstand exposure in the oral environment, which represents an improvement to earlier versions of expanded PTFE in applications such as socket preservation where deliberate membrane exposure offers several advantages. Designed to aid in membrane stabilization Although PTFE is inherently a non-stick material, cells attach to the outside of the dense PTFE membranes. Cellular adhesion is important to...

Products creos™ xenoprotect Porcine collagen membrane creos™ xenogain Deproteinized bovine bone matrix Granule size creos™ xenogain collagen creos™ xenogain + 10% porcine collagen type I Block size Syringe size creos™ mucogain Porcine collagen matrix Block size

creos™ syntoprotect PTFE membrane Shape Designed specifically for extraction site grafting and augmentation procedures where exposure to the oral cavity is common creos™ syntoprotect Ti-reinforced PTFE membrane Shape Designed for narrow single-tooth extraction sites, especially where one bony wall is missing Designed for single-tooth extraction sites, especially where one or more bony walls are missing Designed for large buccal defects Designed for large extraction sites and limited ridge augmentation Designed for large extraction sites and limited ridge augmentation in the anterior maxilla...