Bioactive Bone Substitute Synthetic Bone Substitutes Bioactive Glass Technology

BIOMATERIALS FOR TRUE BONE REGENERATION NORAKER® has been involved in biomaterial development since 2005. It’s today an innovative manufacturer of medical implants for bone regeneration, with its core technology: the BIOACTIVE GLASS, a synthetic bioresorbable ceramic. The bone substitutes Activioss ® Granules and Activioss® Putty are made of bioactive glass. This ceramic is composed of Silicium, Calcium, Sodium and Phosphorous, minerals naturally present in the human body. The natural composition allows an excellent biocompatibility. 1 2 3 The Bioactive glass has been classified by Dr Larry Hench...

Activioss® range : Injectable Putty and Granules Injectable Putty To mix with patient’s blood, patient’s bone or saline solution 1. Easy to use Granules: Very cohesive and hydrophilic when mixed with serum, blood or autologous bone. Injectable Putty: Ready to use ,can be injected through the syringe. 2. Ionic exchanges At 14 days: formation of an active biological mineral layer of calcium phosphate, with similar composition and structure as human bone.1 3 5 3. Activation phase At 21 days: The increased concentration of minerals improves the differenciation and proliferation of osteoblasts in...

Did you know? Bone substitutes are classified into an Index of Bioactivity.8 Matrix for the bone colonization + Stimulation of stem cells Matrix for the bone colonization Adhesion and Proliferation of mesenchymal stem cells hMSC on Activioss .9 (in vitro study) ® Stem cells adhesion ® on the surface of Activioss (dark dots) Multiplication and differentiation of the stem cells (dark spider web) Extracellular matrix and natural hydroxyapatite in formation Dense extracellular matrix; cells differentiated in osteoblasts Blood Vessel Biomaterial 4. Bone Regeneration Osteoid At 6.5 months, mineralized...

Clinical Results Examples 1: Sinusal bone augmentation using bioactive glass and bone flap repositioning Baly Private clinic Villeurbanne - France A retrospective study evaluated the success rate of implantation after sub-sinusian bone augmentation performed by the modified Tatum technique with repositioning of the bone flap and using the bioactive glass 45S5 (Activioss®) as a bone substitute. The surgical technique is described in an iconographic case: Fifty-eight consecutive cases in fifty-eight patients have been operated with this technique. One hundred eleven dental implants were placed...

Granule size Activioss Injectable Putty ACT-IP1.0 ACT-IP2.5 It is indicated in adults and children (oral surgery only) in case of loss or lack of bone substance for bone defects of traumatic, pathological or surgical origin, in dental/ oral surgery when autologous solutions are not applicable or sufficient.10 Tsigkou, O. et al. Biomaterials. 2009;30:3542-50 Oonishi, H. et al. J. Biomed. Mater Res. 2000;51:37-48. Jones, J.R. Acta Biomaterialia. 2013;9:4457-4486. Xynos, I.D. et al. Calcif Tissue Int. 2000;67:321-9. Hench, L.L. J. Mater Sci: Mater Med. 2006;17:967-978. Jell, G. et al. J Mater Sci:...