one Bioactive Bone Substitute Synthetic Bone Substitutes Bioactive Glass Technology

BIOMATERIALS FOR TRUE BONE REGENERATION NORAKER® has been involved in biomaterial development since 2005. It’s today an innovative manufacturer of medical implants for bone regeneration, with its core technology: the BIOACTIVE GLASS, a synthetic bioresorbable ceramic. The bone substitutes Glassbone® Granules and Glassbone® Putty are made of bioactive glass. This ceramic is composed of Silicium, Calcium, Sodium and Phosphorous, minerals naturally present in the human body. The natural composition allows an excellent biocompatibility. 1, 2, 3 The Bioactive glass has been classified by Dr Larry...

Glassbone® range : Injectable Putty and Granules Injectable Putty Granules To mix with patient’s blood, patient’s bone or saline solution Open & Press! Granules: very cohesive and hydrophylic when mixed with serum, blood or autologous bone. At 14 days: formation of an active biological mineral layer of calcium phosphate, with similar composition and structure as human bone. 1, 3, 5 Injectable Putty: Ready to use, can be injected through the syrin

Bone substitutes are classified into an Index of Bioactivity. 8 Matrix for the bone colonization + Stimulation of stem cells Matrix for the bone colonization Adhesion and Proliferation of mesenchymal stem cells hMSC on Glassbone® . 10 (in vitro study) Stem cells adhesion ® on the surface of Glassbone (dark dots) Multiplication and differentiation of the stem cells (dark spider web) 3. Activation phase At 21 days: The increased concentration of minerals improves the differenciation and proliferation of osteoblasts in the defect; and starts the formation of the extra-cellular matrix of collagen....

Clinical Results Examples 1: Clinical and radiographic evaluation of bioactive glass in posterior cervical and lumbar spinal fusion*. In this retrospective study, 30 patients with degenerative and traumatic pathologies of the cervical or lumbar spine underwent spinal fusion using a bioactive glass synthetic bone graft substitute (Glassbone®, Noraker, Lyon-Villeurbanne, France). Pain was assessed by VAS score and graft union by 1-to-1 postoperative radiographic images. Multilevel fusions accounted for the majority of the cohort (43% of patients with more than seven levels treated). Radiographic...

Glassbone® is intended for bone substitution to fill, rebuild, fuse bone defects, when autologous solutions are not applicable or sufficient, pending the regeneration of the bone. 9 Main indications : Bioactive Bone Substitutes References Granule size ORTHOPAEDIC SURGERY SPINAL SURGERY CMF / ENT SURGERY DENTAL SURGERY Glassbone® Injectable Putty GB-IP1.0 Tsigkou, O. et al. Biomaterials. 2009;30:3542-50 Oonishi, H. et al. J. Biomed. Mater Res. 2000;51:37-48. Jones, J.R. Acta Biomaterialia. 2013;9:4457-4486. Xynos, I.D. et al. Calcif Tissue Int. 2000;67:321-9. Hench, L.L. J. Mater Sci: Mater Med....