Guidance for anti-VEGF intravitreal injections during the COVID-19 pandemic Operio sterile Laminar Air flow unit eliminates over 99.9% of Covid-19 Operio sterile Air Flow: the device works with high-purifying Hepa H 14 filters which purify the air in the operating filed and, on the instruments, practically completely (99.9%) of bacteria, viruses (also coronavirus SARS-CoV-2) and other microorganisms. The unit creates an ultraclean area to perform intravitreal injections both in office setting as well as in an ambulatory room or operating theater with up to 100-fold more aseptic conditions than a convectional operating room ISO 7 for eye surgery. The unit allows to create a Covid-free zone to treat patients with maximum of safety (also during examination of Ophthalmology patients) Patients requiring IVI therapy are often at increased risk for complications associated with COVID-19 given their age and comorbidities. Management of patients with retinal disease receiving intravitreal injections during the COVID-19 pandemic will require adjustment to regular clinical practice to minimize the risk of exposure of patients and healthcare staff, and to prioritize those with the greatest medical need.. Operio sterile Air Flow: the devices work with high-purifying Hepa H 14 filters which purify the air in the operating field for intravitreal injections and on the instruments practically completely (99.9%) of bacteria, viruses (also coronavirus SARSCoV-2) and other microorganisms . With this principle, an extremely high level of antiseptic conditions can be achieved in an office setting as well as in an operating theater which was previously only possible in a very expensive ISO 5 operating rooms. The devices can be positioned in such a way that a “germ-free zone” is set up, which offers the greatest possible protection for both the surgical team and the patient. The devices filter 400 m3 of air per hour so that the microorganisms in the entire room can be reduced. Areas of application: intravitreal injections, cataract surgeries, glaucoma surgeries, refractive surgery, laser surgery, etc. The devices are extremely efficient because they precisely protect the area of the surgical field and instruments recommended by the German Robert Koch Institute from bacteria and microorganisms without obstacles such as surgical microscope or OR light. Furthermore, Operio can increase the personal protection of surgeons and operating room personnel Normeditec (Nordic Medical Technology) Germany Heilbronn Tel.: +49 (0) 7139/ 20 90 85 9 Fax: +49 (0) 7139/ 59 34 98 6 Email: [email protected] www.normeditec.com Italy Parma Tel +39 348 730 24 45 [email protected]

Traditional air flow ceilings only work very limited Operio: prepare the instruments protected With Operio, the instruments and implants can always be prepared in the protected area with the sterile Air Flow devices. Then the operating instrument table is simply moved to the operating area and the protection area is then expanded to include the operating area. With conventional supply air ceilings, the protection area of the instruments is only guaranteed within the supply air ceiling - the instruments are almost always unpacked outside the supply air ceiling and the sterility of the instruments...

Intravitreal injectiones The sterile OP-Air Flow device Operio enables inexpensive aseptic conditions to be created for operations and intravitreal injections in eye surgery. The devices work with high-purifying Hepa H 14 filters which purify the air in the operating room and on the instruments practically completely (99.995%) of bacteria and other microorganisms. You combine the advantages of outpatient surgery (shorter intervention times, lower costs, better profitability, more patient satisfaction) while maintaining asepsis, which is comparable to a conventional operating room. Intravitreal...

Technical specifications The Operio devices are extremely small and handy and can also be used in very small rooms. The removable instrument table from Operio is available in various lengths of 45 cm (for intravitreal injections), 60 cm (for ophthalmic operations and intravitreal injections) and 75 cm (for operations that require a lot of instruments). The electrical height adjustment can be carried out by the sterile OR staff (using a sterile covered display) as well as by the other OR staff using a separate display. There is no need to purchase a separate instrument table for storing the instruments....