Nx2me™
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Nx2me™ Connected Health Why Connected Health? Connects clinicians with their home hemodialysis patients, enabling timely exchange of health information and improving the patient experience

Why Connected Health? Dialysis population growth is expected to challenge the system 2025 Dialysis Outlook1-3 More centers More nephrologists More staff References: Data sources for calculation: 1. McCullough KP, Morgenstern H, Saran R, Herman WH, Robinson BM. Projecting ESRD Incidence and Prevalence in the United States through 2030. J Am Soc Nephrol. 2019;30(1):127–135. 2. Census Bureau 2017 National Population Projections Dataset-1. 3. USRDS 2019 Reference Table D.6: Counts of point prevalent ESRD

Why Connected Health? The Advancing American Kidney Health Executive Order • Calls for 50% of dialysis patients to be dialyzing at home by 2025.1,2 References: 1. Rosenberg ME, Ibrahim T. Winning the War on Kidney Disease, Perspective from the American Society of Nephrology. CJASN 14: 1792-1794, 2019. 2. USRDS historically reports that 30% of ESRD patients have a functioning graft. Facilities and managing clinicians will need 50% of patients using home dialysis in order to achieve a goal of 80% home dialysis and transplant patients by 2025.

Nx2me Overview Connected Health can play a key role in reaching 50% by 2025 Enhance Clinician Productivity & Efficiency Improve Retention Nx2me is designed to... Reduce Patient Burden & Instill Confidence Enhance Care Communication Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communication

Nx2me Overview Data captured from patients is available to clinicians and NxStage Technical Support Home Tech Support & Nurse Virtual Session Clinician Portal NxStage Secure Servers Patient Vitals and Assessment Nx2me works over a Wi-Fi network established at the patient’s home. If a patient doesn’t have Internet service, a cell data plan may be available. All patient information is encrypted and transmitted using secure Internet protocols. Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communicatio

Nx2me Overview Nx2me App With easy-to-use navigation and large display, Nx2me is designed to give patients more confidence in their ability to perform treatments at home. Nx2me helps to eliminate tasks performed by the patient (such as filling out flowsheets manually) or making tasks easier or less time-consuming (such as logging blood pressure or weight.) Data collected in the Nx2me app can include: • Treatment information directly from the NxStage HHD cycler* • Patient weight, blood pressure, and temperature can be captured via Bluetooth-compatible devices. • Medications taken • Notes and...

Nx2me Overview Nx2me Clinician Portal Once a patient finishes a treatment, data recorded in the Nx2me app is transmitted directly to the Nx2me Clinician Portal, where it can be reviewed by clinicians. Treatment records are accessible 24/7. Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communication

Nx2me Overview Virtual Sessions & Picture Sharing Virtual Sessions • Streaming video and cycler data allows for faster and more effective support by NxStage Technical Support and nurses. Virtual Session • View patient’s current rates, volume, pressures, and cycler status – as well as Treatment Cycler Values (such as Alarms) from prior to the Virtual Session. Nurse Virtual Session View Picture Sharing • May enhance communication with clinician Virtual Session Patient View Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Commun

Nx2me Overview Nx2me App Phone Calls Patients can call NxStage Technical Support or their Dialysis Center directly from Nx2me with a Wi-Fi Internet connection • Accessible to patients directly within the Alarm Troubleshooting window • Available at any time from the Nx2me App Menu • Reduces patient burden in needing a secondary phone device to call for support during treatment • Virtual Sessions can easily be added to a Phone Call by NxStage Technical Support or a Nurse • Dialysis Center phone numbers are configurable within Nx2me App Settings in the Clinician Portal Clinician Productivity &...

Retention Nx2me delivers quantifiable benefits such as enhanced therapy retention1 All Study Patients Lower therapy discontinuation rate (excluding death and transplant)1 Source: 1. Weinhandl ED, et al. Hemodial Int. 2018 Jul;22(3):318-327. doi: 10.1111/hdi.12621. Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communication

Retention Potential Key Benefits 1. Adherence Clinicians may monitor and support treatment adherence. Clinicians may identify health problems before unscheduled care is needed (blood, arterial, or venous pressures running too high). Notifications (to patients and nurses) when key clinical parameters deviate from preestablished norms may help support patient case management. Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communication

Retention Nx2me Reports Flowsheet Summary & Flowsheet Calendar Report These reports help clinicians better monitor patient adherence and health status to determine if timely intervention is needed. Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communication

Adapting to Patients’ Unique Needs Patients receive alerts in the Nx2me App when their prescription has been updated. Additional alerts for vitals, such as blood pressure, can also be configured to let patients know when they exceed limits set by their clinician. Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communication

Clinician Productivity & Efficiency Billing and Nurse Productivity Nx2me Connected Health is designed to reduce the effort of collecting flowsheets and allows for more proactive care. Nx2me helps clinicians better monitor: • Automatic capture of NxStage HHD cycler data • Timely access to records • Electronic flowsheets • Ability to interface with EMR and billing systems *The Nx2me app does not control the NxStage HHD cycler. Clinician Productivity & Efficiency Instill Patient Confidence Enhance Care Communic