Navilas® Clinical Results: Diabetic Macular Edema Introducing a Better Treatment Paradigm for Patients and Physicians 65 % Injection-free after loading phase Ranibizumab Monotherapy Navilas®+ Ranibizumab See study details inside. % Injection-free after loading phase

Addressing Treatment Burden in Diabetic Retinopathy CAVNAV – Combination Anti-VEGF and Navigated Laser in Diabetic Macular Edema A 12-month, prospective, comparative cohort study of 66 patients with DME. Marcus Kernt, MD and colleagues, LMU Munich, Germany* Standardized combination regimen and control 3x ranibizumab Navilas®+ Ranibizumab n=34 navilas® Ranibizumab Monotherapy n=32 monthly visits for 12 months of total follow-up Results overview Ranibizumab Monotherapy Equivalent or better visual improvement (ETDRS letters gained, mean) Signficantly reduced number of injections (Post loading phase...

CAVNAV combination therapy patients demonstrated stable visual gains achieved with significantly less injections after Navilas. Gains from baseline were significant in both cohorts (p<0.001), cohort differences n.s. change in etdrs letters Navilas®+ Ranibizumab Ranibizumab Monotherapy 65% of combination therapy patients remained injection-free after ranibizumab loading and Navigated Laser. 84% of monotherapy patients required retreatment. Ranibizumab Monotherapy Navilas®+ Ranibizumab

US-based CAVNAV study supports similar results for Navilas + Bevacizumab combination. Change in ETDRS letters Total injections in 12 months Post loading phase injections% patients injection-free after loading phase 16% 65% 57% "Navilas® allows for a highly standardized and reproducible treatment. With image-based planning and accurate navigated execution, our diabetic patients appear to have a reduced need for re-injections in the year after Navigated laser therapy. This type of combination therapy may very well be the preferred solution for most DME patients in the future." William R. Freeman,...

Entering A New Era of Retinal Disease Management Navilas® Benefits over Conventional Laser Higher Accuracy +28% Accuracy and precision through image-guided laser pre-positioning 1,2 microaneurysm/plan spot hit rate Less Retreatments - 42% Navilas® Completeness through standardized digital planning and documentation Durability, lower retreatment rate in laser monotherapy 3 Retreatments during 8 mo. follow-up “ o longer is retinal laser treatment a leap of faith. The Navilas system enables me to see N on the screen where the navigated laser will hit based on the treatment plan designed from the...

Don‘t miss the Eyetube series on Navilas Navigated Laser Therapy: http://eyetube.net/ search.asp?q=navilas The Navilas® Navigated Laser System, a clinically significant advance in the management of retinal disease, reduces treatment burden on patients and staff and is also a sound investment for the practice. • N avilas® distinguishes the practice as a technology center of excellence you to efficiently meet the needs of a growing referral base while optimizing patient flow patient compliance by reducing the number of repeat injections comprehensive technology designed to effectively manage a...