Packaging size Bulk volume [3] Art.-No. PerOssal®Resorbable Bone Substitute PerOssal® • The osteoconductive synthetic bone substitute • Prolonged protection against microbial colonization if preloaded with suitable antibiotics [6, 7] • Completely biodegradable during osteoneogenesis [5] • No subsequent explantation necessary References [1] Rauschmann et al. (2005), Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections, Biomaterials. 26(15):2677-2684. [2] Englert et al. (2007), Konduktives Knochenersatzmaterial mit variabler Antibiotikaversetzung [Conductive bone substitute material with variable antibiotic delivery], Unfallchirurg. 110(5):408-413. [3] Standardized bulk volume, data on file at OSARTIS GmbH. [4] von Stechow and Rauschmann (2009), Effectiveness of combination use of antibiotic-loaded PerOssal® with spinal surgery in patients with spondylodiscitis, Eur Surg Res. 43(3):298-305. [5] Kraus und Schnettler (2008), Gutachten bei Osteitis [Expert opinion in osteitis], in: Bericht uber die Unfallmedizinische Tagung in Mainz am 8./9.11.2008, Deutsche Gesetzliche Unfallversicherung (Hrsg.), [6] Fleege et al. (2012), Systemische und lokale Antibiotikatherapie bei konservativ und operativ behandelten Spondylodiszitiden [Systemic and local antibiotic therapy of conservative and operative treatment of spondylodiscitis], Orthopade. 41(9):727-735. [7] Fleege et al. (2020), Development and current use of local antibiotic carriers in spondylodiscitis: Pilot study on reduction of duration of systemic treatment, Orthopade. 49(8):714-723. [8] Fleege et al. (2017), Antibiotikatherapie der pyogenen Spondylodiszitis bei Erwachsenen [Antibiotic therapy of pyogenic spondylodiscitis in adults], Die Wirbelsaule. 01(4):265. [9] Release kinetic data on file at OSARTIS GmbH. [10] Visani et al. (2018), Treatment of chronic osteomyelitis with antibiotic-loaded bone void filler systems: an experience with hydroxyapatites calcium-sulfate biomaterials, Acta Orthop Belg. 84(1):25-29. [11] Sakellariou et al. (2015), Combination of Calcium Hydroxyapatite Antibiotic Carrier with Cement Spacers in Peri-Prosthetic Knee Infections, Surg Infect. 16(6):748-54. [12] Jimenez-Martin et al. (2008), Use of calcium sulfate and hydroxyapatite with antibiotics in osteomyelitis of £n the hand: Two clinical cases. Utilidad del sulfato calcico e hidroxiapatita con antibioticos en las osteomielitis de la mano, a proposito de 2 casos clmicos, Trauma Fund MAPFRE 20(1):45-48. Auf der Beune 101, 64839 Munster, Germany PerOssal® www.osartis.de OSARTIS

PerOssal® Dosage Recommendation* for Antibiotic Load PerOssal® is intended for the restoration of bone In vitro release of the tested antibiotics from defects. After thorough surgical debridement and PerOssal over a period of 10 days under systemic or local antibiosis, it may be also implanted in infected or contaminated areas. PerOssal is a synthetic, biodegradable and osteo® conductive bone substitute material for restoration ces (such as antibiotics) and their controlled sus- and filling of bone defects. Its unique microporous structure ensures uniform uptake of liquid substan- PerOssal has...