iLine F PRO
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iLine F PRO LIVE CELL ANALYZER Optimize your bioprocess efficiency through real-time cell monitoring VISIT OVIZIO.COM

Shed light on your cells The Ovizio iLine F PRO provides you with improved insight Cell detection is made possible through machine-learning into your cell-based processes by bringing real-time monitoring of Cell Quality Attributes (CQA’s). parameters such as viability, bead count, cell activation profile, cell infection status, etc. Based on label-free analysis, our analyzer ensures continuous monitoring of your cells status’ without the Our user-friendly software integrates remote-monitoring and manual handling usually required. automation features for improved cell-monitoring. Secured...

Benefits Achieve continuous cell monitoring Automated analyzer Drastically reduce handling operations Closed-loop system Drastically reduce risk of external contamination Eliminate wasted biological material Machine Learning algorithms Achieve reproducible measurements Identify multiple Cell Quality Attributes (CQAs) Customize your cell classification Continuous cell monitoring Remote monitoring Early detection of cell-growth issues Alert triggering options Open platform Optimize your bioprocesses & feeding strategy Reduce time-to-harves

iLine F PRO The iLine F PRO enables label-free cell analysis through holographic imaging. The analyzer is easy to use and only features one button for on/off operations. It is equipped with a built-in computer and and a 7 inch touchscreen display to enable continuous display of the ongoing cell monitoring. Data can easily be backed up through a built-in USB port or sent to a dedicated server through the integrated ethernet port. An integrated QR code reader enables BioConnect identification for improved traceability. BioConnect Our BioConnect enables closed-loop connection between the iLine...

Machine Learning Algorithm Our machine learning algorithm will scan each Our software uses machine learning to identify object features and classify cells accordingly image and identify all visible objects, such as cells and beads. For each of these objects, it will measure multiple features and combine them into a biological signature. This signature will be utilized for cell classification and enables identification of different cell culture Membrane Regularity Cell viability Cell count Magnetic bead count Morphological changes Object Features

OsOne Software Example of CHO Cells cultivated in Dasgib bioreactor for 7 days. Phase with overlay The OsOne software is at the center of Ovizio's analyzers. Designed to deliver an attractive user experience, OsOne is built for easy data acquisition and thorough quantitative data analysis of suspension cell cultures. The intuitive interface and wizard enable a rapid understanding and navigation through the app. Improved user traceability has been integrated ensure compliance with FDA norm CFR21/11.

Specifications Ovizio reader iLine F holographic transmission microscope Cell concentration range Cell counting range of 0.5 to 10 Mcells/mL The device provides a ± 10% cell density variation Light source Partially coherent monochromatic LED 630 nm (red) C-MOS camera 2456 (H) x 2058 (V) – 8 bits Cell travel time 5 to 25 min. Varies according to specific setup (pump profile, total …) Analyzer objective Olympus LUCPLFLN20X analyzer objective 20x – 0.45 NA Tubing length Total magnification Welding interface Horizontal resolution From 300 mLto 10.0 L total process Acquisition rate Retention volume...