Amplification-Free Targeted Sequencing
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Amplification-Free Targeted Sequencing - 1

AMPLIFICATION-FREE TARGETED SEQUENCING ACCESS PREVIOUSLY INACCESSIBLE GENOMIC REGIONS THE LEADER IN LONG-READ SEQUENCING Due to technology limitations, repeat-expansion disorders have gone without the needed base-level resolution of the disease causative long repetitive elements1,2,3. Enrichment of these hard-to-amplify genomic regions is now possible with our amplification-free targeted sequencing method utilizing the CRISPR/Cas9 system. By combining CRISPR/Cas9 enrichment with Single Molecule, Real-Time (SMRT®) Sequencing on the Sequel® System, scientists are now able to: ------ Eliminate PCR bias and errors Sequence through entire repeat expansions with base-level resolution Quantify repeat numbers in normal- and mutant-expanded alleles Identify interruption sequences Characterize somatic mosaicism VISUALIZATION OF INTERNAL REPEAT STRUCTURE ALLELE-SPECIFIC REPEAT COUNT IN FRAGILE-X PREMUTATION DISEASE SAMPLE ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●●●●●●●●●●●●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●●●●●●●●●●●●● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●●●●●●●●●●●●●●●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ● 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Open the catalog to page 1

All PacBio catalogs and technical brochures