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Behavioral Research

Behavioral Research

Product catalog summary

Overview: This document is a catalog from Harvard Bioscience, Inc., detailing a range of products and solutions for behavioral research, electrophysiology, and neuroscience. It highlights the company's commitment to high-quality products and customer support, with a focus on innovation and integration of new technologies.

Main Sections:

Product Offerings: The catalog lists various tools and systems for research, including video tracking systems, operant conditioning setups, and electrophysiology solutions. Key products include the SMART Video Tracking System V3.0, modular operant boxes, and solutions for neural recording and stimulation.
Research Applications: The products are designed for a wide range of applications in psychopharmacology, neuroscience, and behavioral studies. These include studies on cognition, memory, emotion, and related pathologies such as Alzheimer's and Parkinson's disease.
Technical Support: Harvard Bioscience emphasizes its pre- and post-sales support, offering assistance with system configurations and technical questions through its team of scientists.
Innovative Solutions: The catalog highlights the integration of new technologies and the synergy created by combining expertise from different divisions, such as Triangle Biosystems International and Multi Channel Systems.
Detailed Product Descriptions: Each product section provides detailed descriptions, including key features, parameters measured, and specific applications. For example, the SMART Video Tracking System V3.0 is noted for its flexibility, reliability, and advanced data analysis capabilities.

Key Features and Benefits:

Modular and Flexible Systems: Many products, like the SMART Video Tracking System, offer modular structures to fit various experimental needs and budgets.
Advanced Data Analysis: Products include customizable data reports and calculations for a wide range of behavioral paradigms.
Integration and Synergy: The catalog emphasizes the integration of behavioral analysis with in vivo neuronal recording and stimulation, enhancing research capabilities.

Conclusion: Harvard Bioscience provides comprehensive solutions for behavioral and neuroscience research, with a focus on quality, innovation, and customer support. The catalog serves as a detailed guide for researchers looking to enhance their experimental setups with advanced tools and technologies.

SMART Packages Overview: The document outlines various SMART packages designed for animal behavioral experiments. The packages include the SMART Basic Pack, Super Pack, and Premium Pack, each offering different modules for flexibility in experimental setups. The Basic Pack is suitable for one animal in one arena, while the Super and Premium Packs add more modules for enhanced functionality.

SMART Video-Tracking System V3.0: This system provides video tracking capabilities for behavioral experiments. It includes features for tracking calculations, specific calculations like arm choice and alternation triplets, and time evolution reports. The system supports various experimental modules such as open field, water maze, and social interaction.

Ordering Information: The document provides order numbers and descriptions for different SMART V3.0 packs, platforms, extensions, and accessories. It also includes details for digital video recording systems under the RECORD-IT! line, which ensures traceability and security of experimental data.

RECORD-IT! Digital Video Recording Systems: These systems offer options for external digital video recording, compatible with the SMART system and other tracking programs. Key features include traceability, compatibility with multiple cameras, and the ability to generate independent digital video files.

LimeLight Video Tracking Software: LimeLight is a flexible video tracking system that can track up to four arenas simultaneously. It offers features for zone creation, behavior scoring, and data export. The software is designed for various applications like open field and plus maze testing, providing detailed analysis and statistics.

Key Features and Parameters: The document highlights key features of the video tracking systems, such as distance traveled, time spent in regions, body length measurements, and latency to zones. It also mentions the components included with the software, such as instruction manuals and software updates.

Overview: The document provides detailed information on various video tracking software and behavioral test systems used in animal research. It includes descriptions of LimeLight and WaterMaze software, as well as the Habitest Modular Behavioral Test Systems.

LimeLight Video Tracking Software:

Features video buttons and key commands for trial viewing.
Offers analysis options such as grid crossings, distance traveled, and time spent in each grid square.
Data can be exported to Excel for further analysis.
Allows for partial trial analysis and custom zone creation.
Supports tracking based on different body parts and complex analyses.
Batch exporting of data is available for grouped trials.

WaterMaze Video Tracking Software:

Designed for Morris Water Maze experiments.
Includes a Project Manager for complex trial sequences.
Tracks parameters like thigmotaxis, quadrant times, and crossings.
Allows for easy setup with standard cameras and robust tracking capabilities.
Data can be exported to Excel and other formats for analysis.

Habitest Modular Behavioral Test Systems:

Offers maximum flexibility with modular test arenas.
Supports a wide range of behavioral tests including mazes, operant conditioning, and avoidance tests.
Features modular design for reconfigurable options and a variety of stimulus response sensors.

Ordering Information: The document lists various products and accessories available for purchase, including software upgrades, USB interfaces, camera kits, and test cages for mice and rats.

References: The document cites several studies and articles related to the use of these systems in research.

Overview: This document provides detailed information on various equipment and software used for behavioral research, particularly focusing on operant conditioning systems for mice and rats. It includes specifications, ordering information, and references to scientific studies.

Specifications and Equipment:

Shock Level Tester: A13-16 model with a 25 ft. shock cable.
Gustatory Stimuli: Pellet delivery troughs and feeders for mice and rats, with specific models for different pellet sizes.
Levers and Lickometers: Various models for mice and rats, including retractable and optical versions.
Response Sensors: Contact sensors and infrared activity monitors are available.

Operant Conditioning Systems:

Habitest Modular Behavioral Test Systems: Suitable for a range of experiments including self-administration, variable interval, and fixed ratio tests.
Graphic State® 4 Software: Enhanced software for designing and running behavioral experiments with features like USB interface, math function capabilities, and improved time resolution.
Modular Operant Box: A flexible system that can be customized for different experimental needs, supporting up to 8 stations connected to a PC.

Software and Analysis:

Packwin V2.0 Software: A modular and user-friendly platform for conducting operant procedures, offering real-time calculations and advanced reporting features.

References: The document cites various studies related to behavioral research, highlighting the application of the equipment in scientific experiments.

Ordering Information: Detailed product codes and descriptions are provided for easy ordering of equipment and software upgrades.

Overview: The document provides detailed information about Packwin and Tru Scan software systems used for behavioral experiments in research settings. These systems are modular and customizable to meet specific research needs, focusing on operant conditioning and locomotor activity monitoring.

Packwin Software:

Customized Module: Allows researchers to create complex protocols without needing to learn programming languages. It supports various operant procedures such as associative learning, memory tasks, addiction studies, attention tests, and anxiety & depression protocols.
Pre-Configured Test Modules: Offers ready-to-use templates for standard behavior experiments, including modules for 5-Choice Serial Reaction Time Test, Vogel Test, fear conditioning, and startle response evaluation.
Parameters Measured: Includes detailed reports on experiment duration, response patterns, and specific metrics for each module, such as correct/incorrect responses, latencies, and freezing episodes.

Tru Scan for Open Field Activity Monitoring:

Key Features: Provides precise tracking in small arenas for mice, with options for audio, visual, and electrical stimuli. It is scalable and allows for simultaneous nose poke and floor plane activity monitoring.
Data Analysis: Automated data analysis with results presented in tables or graphs. Raw data can be re-analyzed to find additional behaviors or effects.
Versatility: Supports various tasks such as nose poke, place preference, and conditioned freezing. Accessories like shock floors and noise generators enhance functionality.

IR Actimeter for Locomotor Activity Assessment:

System Components: Includes IR frames for monitoring locomotor activity, rearing, and exploration in rodents. The system is modular and adaptable for different species and experimental conditions.
Features: Offers up to 15 sensitivity levels and can ignore obstructed beams. Suitable for both short-term and long-term experiments.

References: The document cites various studies that utilized these systems, highlighting their application in research on addiction, memory, attention, and other behavioral studies.

Overview: The document provides detailed information on various systems and software used for monitoring and analyzing locomotor activity and circadian rhythms in rodents. It includes specifications, features, and ordering information for different models and software.

Key Features and Specifications:

The systems can be controlled independently or via SEDACOM software, allowing data export to Excel through RS-232/USB ports.
ActiTrack software offers additional analysis of animal trajectories, including distance, speed, and time spent in selected zones.
Interchangeable frames are available for different activity modes, and the system can operate without a computer.
Simultaneous recording is possible for up to 16 cages or 32 IR frames.
Parameters measured include stereotypies, rearings, nose-pokes, global activity, and inactivity intervals.

ActiTrack Software:

Controls up to 32 frames and provides spatial position and displacement patterns.
User-adjustable thresholds for classifying activity into fast, slow, and resting movements.
Allows track re-analysis with user-defined zones and replay of experiments with different speed thresholds.
Measures traveled distance, speed, permanence time, and number of zone entrances.

Rodent Activity Wheel and Cage:

Quantifies rodent voluntary exercise in home cage environments with external or internal wheel options.
Suitable for rats, mice, and hamsters, and ideal for high throughput experiments.
Data can be stored in user-defined intervals and exported to SEDACOM PC interface.

ClockLab Software for Circadian Biology:

Offers sophisticated data analysis for circadian biology studies with a user-friendly interface.
Measures phase shifts, mean alpha, and predicts future activity onsets.
Supports up to 448 channels and integrates light control and recording.
Allows remote data access and real-time viewing of actograms.

References: The document cites various studies and research papers that have utilized these systems and software for different experimental purposes.

Overview: The document provides detailed information on various scientific studies and equipment related to circadian biology, sensory motor coordination, and behavioral neuroscience. It includes references to research articles and descriptions of equipment used in these fields.

Research Studies:

Wilcockson (2013) - Discusses the dissociation of circadian and circatidal timekeeping in marine crustaceans.
LeGates et al. (2012) - Examines how aberrant light affects mood and learning through melanopsin-expressing neurons.
Fonken et al. (2012) - Investigates the impact of dim nighttime light on cognition and depressive-like responses in rodents.
Eastwood et al. (2012) - Studies the effects of neonatal methamphetamine and thioperamide exposure on spatial memory and circadian activity.
Karatsoreos et al. (2011) - Explores the effects of circadian clock disruption on metabolism, brain, and behavior.

Equipment Descriptions:

Big Brother Video-Based Tracking System: Used for tracking animal behavior in neuroscience and circadian biology. It can monitor up to 200 animals and provides high temporal resolution with infrared sensitivity.
Grip Strength Meter: Evaluates muscular strength in rodents, measuring the maximum force developed by the front and hind paws. It is used to assess neuromuscular functions and potential neurotoxicity.
Rota Rod: Tests motor coordination, endurance, and fatigue resistance in rodents. It features a touchscreen interface and can measure latency to fall and rotation speed.
Small Animal Treadmill: Used for forced exercise training and fatigue testing in rodents. It offers adjustable speed and slope, with a touchscreen interface for data visualization.

Key Features and Specifications:

Big Brother: Easy setup, flexible tracking, high temporal resolution, and compatibility with ClockLab for circadian analysis.
Grip Strength Meter: Standalone system, multi-unit display, and RS-232 connection for data output.
Rota Rod: Touchscreen interface, mechanical fall detection, and precise speed regulation.
Small Animal Treadmill: Silent operation, accurate shock intensity control, and positive/negative slope adjustment.

Conclusion: The document provides comprehensive insights into the tools and methodologies used in circadian biology and sensory motor coordination research. It highlights the importance of precise measurement and analysis in understanding animal behavior and physiology.

Overview: The document provides detailed information on various laboratory equipment designed for sensory motor and coordination experiments in small animals. It includes specifications, ordering information, and optional accessories for treadmills, rotameters, rodent shockers, and data transfer software.

Specifications: The equipment includes single, double, and 5-lane treadmills with adjustable current range (0 to 2 mA) and belt speed (5 to 150 cm/sec). Shock grids and air-puff options are available for ethical considerations. The rotameter measures rotational behavior with adjustable sensors and harnesses for different animal sizes. The rodent shocker is used for testing anticonvulsant drugs with safety features and adjustable current settings.

Procedures: The document outlines the use of treadmills for indirect calorimetry experiments and the rotameter for evaluating rotation behavior in animal models of Parkinson’s Disease. The rodent shocker is used to induce seizures for anticonvulsant drug testing.

Standards and Recommendations: The equipment complies with CE standards and requires specific power supplies (110 or 220 Vac, 50/60 Hz). The air-puff option is recommended as a more ethical alternative to electrical shocks.

Data Management: SEDACOM V2.0 software facilitates data collection and exportation for further analysis. It supports various devices and allows for easy data visualization and exportation in compatible formats.

Ordering Information: Detailed product codes and descriptions are provided for each piece of equipment and accessory, including optional software and adapters.

Key References: The document cites studies that have utilized the equipment for research on exercise, anticonvulsant drugs, and Parkinson’s Disease models.

Overview: This document provides detailed information on various devices and methods used for evaluating thermal analgesia in laboratory animals. It includes specifications, key features, components, and options for each device, along with references to scientific studies.

1. Tail Flick Meter:

Key Features: Optimal detection with perfect alignment of heat stimulus and photo beam trigger, adjustable sensitivity, manual and remote timer, automatic cut-off, and optional data transfer software (SEDACOM V2.0).
Parameters Measured: Time latency response to thermal stimulus.
Components Included: Control unit, stimulation unit, mouse tail adapter, holder for rat or mouse, footswitch, instruction manual, calibration certificate, cables, connectors, and spare fuses.
Options: Tail-Temperature recorder, SEDACOM software, RS-232/USB adapter.

2. Hot-Plate for Evaluating Thermal Analgesia:

Key Features: Digital set point, built-in electronic timer, foot switch timing operation, and optional data transfer software (SEDACOM V2.0).
Parameters Measured: Time latency to 'paw licking' and 'jumping'.
Components Included: Base with heating plate, footswitch, cables, connectors, calibration certificate, instruction manual, and spare fuses.
Specifications: Temperature range of 45 to 62°C, reaction time precision of 0.1 sec, and CE compliant.

3. Hot/Cold Plate for Testing Animal Sensitivity:

Key Features: Unmatched temperature stability, fast acclimation, homogeneous temperature distribution, and BSRamp software for temperature ramps.
Parameters Measured: Animal reaction time to hot or cold stimulus.
Specifications: Temperature range from -3°C to 65°C, accuracy of ±0.5°C, and automatic power requirements.

4. Thermal Place Preference:

Key Features: Monitor thermal place preference and nociceptive thresholds, unrestrained animals, and optional automatic detection software.
Parameters Measured: Time spent in each zone, time of zone trespassing, and temperature of each zone.
Specifications: Temperature range from -3°C to +65°C, accuracy of ±0.5°C, and dimensions including cage.

5. Thermal Gradient Test:

Key Features: Continuous thermal gradient, monitor 2 mice or 1 rat, and automated system with video tracking.
Parameters Measured: Time spent in each temperature zone, temperature of zone over time, and overall distance travelled.
Specifications: Temperature range from 5 to 55°C, stability of 1°C, and dimensions for 2 mice/1 rat.

6. Plantar Test (Hargreaves Apparatus):

Key Features: Automatic detection of paw withdrawal, measurement of hyperalgesia, and modular animal enclosure.
Specifications: Operating temperature from 15° to 30°C, adjustable IR intensity, and universal power requirement.

7. Dynamic Plantar Anesthesiometer:

Key Features: Automatic detection of paw withdrawal, consistent force application, and data portability.
Functionality: Automates assessment of touch sensitivity on the plantar surface of rats or mice.

Dynamic Plantar Anesthesiometer: The Dynamic Plantar Anesthesiometer is used to measure the force at which an animal withdraws its paw in response to a stimulus. It features a force range of 0 to 50 grams, adjustable force increase rate, and a filament travel of 12 mm. The device connects to a PC via a DeLta 9-pin connector.

Electronic Von Frey for Evaluating Mechanical Allodynia: This instrument measures mechanical pain sensitivity thresholds in rodents. It offers a measurement range of 0 to 500 grams with high precision and accuracy. The device includes statistical functions for data analysis and can store up to 100 values. It is available with embedded video options and is suitable for both rats and mice.

Paw & Tail Pressure Meter: The Randall & Selitto test measures the threshold response to pain induced by pressure on the paw or tail. The device features a digital display, adjustable pressure increase rate, and footswitch control. It includes a control unit with RS-232 communication and various components for conducting experiments.

Plethysmometer for Evaluating Paw Volume: The Digital Water Plethysmometer measures small volume changes in rodent paws to assess inflammatory responses. It uses a volume transducer with a conductive solution and platinum electrodes. The system includes a control unit, footswitch, and options for different cell sizes.

Dynamic Weight Bearing Test: This test measures the postural equilibrium of freely moving rodents by recording the weight distribution on each limb. Data is captured and analyzed via a USB link, allowing for replay and validation of results.

Dynamic Weight Bearing Test: This test features a floor-instrumented cage for measuring the weight borne by each limb of a freely moving animal. It includes components such as an animal cage, sensor, USB interface, webcam, and software. The system ensures accuracy through initial calibration and records data at a 10 Hz sampling rate with synchronized video. Specifications include dimensions and weight for mice and rats, sensor accuracy, resolution, and range, as well as computer requirements.

Incapacitance Meter: This device assesses spontaneous pain in animals without applying experimental stimuli. It features a touchscreen interface and measures weight distribution on two separate sensors. The test is controlled via a footswitch and can display statistics. Specifications include resolution, average time, and overpressure capacity.

Social Interaction Test: This test evaluates social behavior by allowing an animal to explore an unfamiliar congener. The social box is divided into three compartments with sliding doors and grid enclosures for interaction. It is optimized for video-tracking systems.

Circular Pool for Learning & Memory: The Morris Water Maze is used for spatial memory studies. The pool includes a water pump, thermostat, and tubing, with temperature control between 22-32°C. It is compatible with video-tracking systems for analyzing animal behavior.

Barnes Maze: This test assesses spatial learning and memory using a platform with peripheral holes. The animal seeks a dark goal box, and the time taken to locate it is measured. The maze is made of non-reflective material and is suitable for video-tracking systems.

T-Y Maze: Used for assessing spatial working memory, these mazes are made of non-reflective, odor-resistant material. They are designed for video-tracking systems and are used for tasks like spontaneous alternation.

Overview: The document provides detailed information on various maze systems and software used for evaluating learning, memory, and attention in laboratory animals, specifically rats and mice. It includes specifications, features, and ordering information for different maze models and associated software.

Maze Systems:

T-Y Mazes: Used for evaluating learning and memory. They allow automated standard experiments with options for manual or automated door control and animal detection via photoelectric cells or video tracking.
Radial Mazes: Available in manual, semi-automated, and automated versions. They are used for evaluating working and reference memory. The maze consists of a central area with eight arms, and the doors can be controlled manually or automatically using the Mazesoft-8 software.

Key Features:

Automated and manual control options for maze doors.
Animal position detection using photocells or video tracking.
Data export capabilities to Excel for further analysis.

Software:

MAZESOFT-8: A comprehensive software for monitoring radial maze experiments. It allows for the configuration of protocols for studying working and reference memory, with real-time visualization of animal positions and data export options.

Habitest Runways & Hubs:

Modular design for flexibility and reconfiguration.
Available in various shapes and used for runway intersections in different maze configurations.

Ordering Information: The document provides detailed ordering information for various maze models, software, and accessories, including control units, hubs, runways, and shock cables.

References: The document cites several studies that have utilized these maze systems for research on brain function, memory, and behavior in rats.

Overview: The document provides detailed information on various laboratory equipment designed for behavioral studies in animals, specifically focusing on Passive and Active Avoidance Boxes. These devices are used to assess memory and learning in small laboratory animals through fear-motivated testing.

Specifications and Features:

Passive Avoidance Cages: These include a drop pan, shock floor, photocell sensors, and a barrier/doorway. They are designed with a blacked-out compartment to facilitate memory testing.
Guillotine Doors: Optional doors that can replace open barriers, controlled by a 28-volt signal for safe operation.
Shuttle Boxes: Used for both Active and Passive Avoidance studies, featuring independent grid floors and optional guillotine doors.
Materials: Constructed from methacrylate, aluminum, and stainless steel, ensuring durability and ease of cleaning.
Software Control: The ShutAvoid software manages up to eight boxes, controlling stimuli presentation and recording animal responses.

Key Features:

High sensitivity weight transducers for accurate animal detection.
Stable shock intensity delivery independent of grid bars treaded.
Modular design for flexibility and reconfiguration.
CE compliant with a power supply of 110/220 VAC, 50/60 Hz.

Ordering Information: The document lists various models and accessories available for order, including Passive Avoidance cages for mice and rats, Shuttle Boxes, and related software.

Applications: These devices are primarily used in research to assess short-term and long-term memory in animals, providing insights into learning and memory processes.

Overview: The document provides detailed information on modular shuttle cages and the StartFear Combined System, both designed for animal behavioral experiments, particularly focusing on stimulus-response and fear conditioning studies.

Shuttle Cages: These cages are modular and designed for both mice and rats, allowing for various configurations and applications beyond active and passive avoidance. Key features include photocell sensors for animal movement detection, optional guillotine doors, and easy-to-clean components. The cages can be expanded with additional stimuli, feeders, and response sensors for diverse experimental setups.

Ordering Information: The document lists various products and accessories available for purchase, including software, power bases, connection boards, and specific components for mouse and rat cages.

StartFear Combined System: This system is designed for conducting fear conditioning and startle reflex experiments. It includes a high-sensitivity weight transducer system for recording animal movements and software modules for data analysis. The system is adaptable for different spatial contexts and includes components like soundproof boxes and load cell amplifiers.

Specifications: The document provides detailed specifications for the experimental chambers, including dimensions, material composition, and power supply requirements. It also lists ordering information for various components and options available for the StartFear system.

FreezeFrame Software: This video-based system is used for fear conditioning experiments, offering high sensitivity and automation. It features a proprietary motion detection algorithm and supports various stimuli control through a computer interface. The software allows for detailed data analysis and export.

References: The document cites several studies and publications related to fear conditioning and startle response research, highlighting the scientific basis and applications of the systems described.

5/9 Hole Box for Attention Performance: The 5/9 Hole Box is designed for evaluating attention performance in laboratory animals. It features black aluminum walls, a transparent front door, and nine apertures with adjustable LED lights for visual cues. The box includes a food pellet dispenser and a nose-poke detector. It is compatible with Packwin V2.0 software for experiment control and data collection, measuring parameters such as correct and incorrect responses, omissions, and response latency. The box is available for both rats and mice, with specific configurations for each.

Elevated Plus Maze & Elevated Zero Maze: The Elevated Plus Maze is used to assess anxiety-like behavior in rodents, featuring a cross-shaped design with open and closed arms. The maze exploits rodents' fear of open spaces versus their exploratory nature. The Elevated Zero Maze offers a similar assessment without a central zone. Both mazes are compatible with video tracking systems and are available in various sizes for rats and mice.

Open Field Box: The Open Field Box evaluates animal activity in response to novel or anxiogenic environments. Available for rats and mice, the box is made of non-odor absorbing material and is easy to clean. It supports video tracking and can be customized for specific research needs.

Aron Test for Screening Anxiolytic Substances: The Aron Test, or Four Plates Test, is an anxiety model where exploration is suppressed by mild electric shocks. It measures the number of punished crossings, with anxiolytic substances increasing these crossings. The test setup includes a control unit and shock generator.

Black & White Test: The Black and White Box assesses anxiety by measuring an animal's movement between compartments with different illumination. It is easy to clean and connect to a PC for data analysis. The test identifies behavioral changes due to pharmacological agents.

Vogel Test: The Vogel Test screens potential anxiolytic properties by measuring the number of licks and shocks received in an animal's home cage. It supports up to 32 cages connected to a single computer and includes a special nipple system to prevent non-specific contacts.

Overview: The document provides detailed descriptions of various experimental setups and equipment used in behavioral studies related to anxiety, depression, reward, and addiction in rodents. It includes specifications, ordering information, and key features of each apparatus.

1. Vogel Test: The Vogel test is designed to assess the anxiolytic properties of drugs by punishing drinking behavior with mild shocks, leading to reduced water consumption. The setup includes a home cage with a grid floor and a special nipple for detecting drinking behavior. The system can handle up to 32 cages, interconnected via RS-232 serial communication. Key specifications include internal memory for 99 trials and shock intensity ranging from 0.1 to 2 mA.

2. Immobilization Board: This board is used for inducing psychological stress in rodents by restraining them. It features a central board with movable arms for paw fixation and a Velcro ribbon for securing the body. The design minimizes physical stress and enhances the quality of psychological stress, ensuring reproducibility in results.

3. Forced Swimming Test: Used for screening anti-depressive effects, this test involves forcing rodents to swim in a transparent cylinder, leading to immobility, which is considered a depressive-like behavior. The test is automated with video tracking options available.

4. Tail Suspension Test: This test screens psychotropic properties of drugs by measuring the energy expended by mice trying to escape suspension. It includes automatic measurement of immobility and can monitor up to 6 mice simultaneously. Results can be exported to Excel.

5. Place Preference Box: Used for assessing conditioned place preference and aversion, this box allows for the combination of visual and tactile cues. It includes weight transducer technology for animal detection and can connect up to 8 stations to a PC. The system is used to study the reinforcing properties of drugs and the neurobiological systems involved in reward and addiction.

6. Spatial Place Preference Box: This box optimizes place preference and aversion studies by allowing differentiation between compartments using visual, tactile, and spatial cues. It is designed to minimize initial place preference and can be used with video-tracking systems for detailed analysis.

Overview: This document provides detailed information on various systems and software designed for laboratory experiments related to reward, addiction, and metabolism studies in animals. It includes descriptions of the PPCWIN software for conditioned place preference tests, the Self Administration Box for studying addiction, and the OxyletPro System for metabolic studies.

PPCWIN Software:

Designed for conditioned place preference and black and white experiments.
Features include real-time visualization of animal position, integrated results, and exportable data in Excel format.
Measures parameters such as total entries into compartments, permanence time, and latency to first transition.
Includes software installation, USB license key, cables, connectors, and a digital instruction manual.

Self Administration Box:

Modular experimental enclosure for studying reward and addiction.
Features include a removable waste tray, modular components for self-administration, and compatibility with Packwin software.
Measures parameters like number of responses, response rate, and reinforcements received.
Includes experimental chamber, instruction manual, cables, connectors, and a 2-year warranty.

OxyletPro System:

Modular system for studying respiratory metabolism, food and drink intake, and activity in home cages.
Features include high accuracy monitoring, modular design for expandability, and indirect calorimetry for metabolic evaluation.
Measures parameters such as O2 consumption, CO2 production, and energy expenditure.
Includes software modules for metabolism, intake, and activity studies, with data exportable in Excel format.

Key Features and Applications:

Systems are designed to minimize stress to subjects and are easily expandable.
Applications include studies on obesity, diabetes, metabolic disorders, and drug screening.
Software provides real-time monitoring, data analysis, and graphical representation of results.

Overview: This document is a product catalog for Harvard Apparatus and Panlab, focusing on equipment and software for behavioral research. It includes a comprehensive index of products and their applications in various research areas.

Key Sections:

Video Tracking Systems: Includes systems like SMART Video Tracking System V3.0 and WaterMaze Video Tracking System, used for monitoring and analyzing animal movement.
Operant Conditioning: Features Modular Operant Box and related software like Graphic State® 4, used for behavioral experiments involving stimulus-response learning.
Sensory Motor and Analgesia: Products like the Grip Strength Meter and Hot Plate Analgesia Meter are highlighted for assessing motor coordination and pain response.
Social Interaction and Anxiety: Includes systems like the Social Box and Elevated Plus Maze, designed to study social behaviors and anxiety-related responses.
Learning, Memory & Attention: Covers a range of mazes and software like MAZESOFT-8, used for cognitive and memory testing.
Metabolism and Physiology: Features products like the OxyletPro and METABOLISM Software, focusing on metabolic studies.
Electrophysiology & Optogenetics: Discusses in vivo systems for neural recording and stimulation, including optogenetics tools.

Contact Information: Provides contact details for Harvard Apparatus offices worldwide, including the USA, UK, Spain, France, Germany, Canada, and Sweden.

Usage Note: Products are intended for research use only and not for human application unless specific regulations are followed.

Catalog excerpts

Behavioral Research Video Tracking Operant Conditioning Circadian Biology Sensory Motor Analgesia Social Interaction Anxiety & Depression Reward & Addiction Food & Drink / Metabolism Learning, Memory & Attention Locomotor Activity & Exploration In Vivo Electrophysiology & Optogenetics divisions of Harvard Bioscience, Inc. Call to receive other Behavioral Regenerative Medicine Electroporation & Electrofusion Animal, Organ & Cell Physiology Electrophysiology & Cell Biology Research Molecular Sample Preparation catalogs of interest Pumps Surgical Tools

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In addition to our high quality research products, we are proud to offer unparalleled pre- and post-sales support. Our technical staff scientists are happy to help answer any questions you may have or assist with system configurations. ► Product Specifications ► Instruction Manuals ► Working Procedures ► Application Sheets Coulbourn / Harvard Apparatus phone 508.893.8999 • toll free U.S. 800.272.2775 fax 508.429.5732 www.coulboum.com Panlab / Harvard Apparatus Spain +34934190709 • International +34834750697 fax +34934750699 www.panlab.com

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Our products help solve relevant problems in basic and clinical psychopharmacology. Applications include the study of brain functions (cognition, memory, emotion…), the study of related pathologies (Alzheimer’s, Parkinson’s, depression, addiction…) as well as the discovery and screening of new therapeutic compounds. Our goal has always been to offer our customers the best service and full attention which translates into a dynamic business focus, while a constant effort is made to guarantee that high quality standards are accomplished in every detail. The company is constantly renewing and evolving...

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Video Tracking Graphic State® 4 Software pages 16-17 Sensory Motor & Coordination SMART Video Tracking System V3.0 pages 4-7 Analgesia Tru Scan Activity Monitor pages 22-23 Small Animal Treadmills pages 34-35

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Species Guide for Behavioral Systems To help you become more familiar with our product line, we have added small animal icons for every product. These icons will help guide you to which species can be used with each system. Below are the animal icons you will see throughout this catalog.

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Video Tracking SMART Video Tracking System V3.0 Video Tracking • SMART Video Tracking System V3.0 } Flexibility, reliability, productivity and simplicity all } Modular structure to fit all experimental needs, basic and advanced, and budgets } Designed with the latest in both hardware and software technologies, SMART V3.0 represents over 15 years experience for increased functionality and maximum productivity for your experiments

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SMART V3.0 offers the most flexible and easy-to-learn software on the market for the automated evaluation of behavior in the widest range of pre-clinical and neuroscience applications. Utilizing advanced image analysis, SMART V3.0 allows the recording of activities, trajectories, events, social interactions and global activity. SMART V3.0 provides users the versatility of a modular system with the capabilities of a broadband package. Our enhanced data analysis includes customizable data reports and complete calculations for unlimited behavioral paradigms. Developed with the daily experimental...

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SMART Video-Tracking System V3.0 (continued) Video Tracking • SMART Video Tracking System V3.0 Running classic behavior experiments and looking to save time and expense? Opt for our experiment-targeted modules for pre-configured setup and data reports for such tests as water maze (SMART-WM), plus maze (SMART-PM), open field (SMART-OF), place preference (SMART-CPP), forced swim test (SMART-FST), etc. SMART Extensions Our Global Activity Extension - SMART-GA - is ideal for activity related experiments. This option uses frame-to-frame detection for precise monitoring of spontaneous activity and...

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• Information about Subjects, Sessions and Configuration • Tracking calculation in arms, center and total (entries, time, distance covered, speed, resting/slow/fast displacements etc.) • Specific calculations: first arm choice, first arm choice latency, spontaneous alternation triplets, Max Alternation triplet, total arm entries • Time evolution report lists (zone transitions, scored events) • Group evolution graph SMART-CPP (Conditioned Place Preference) • Information about Subjects, Sessions and Configuration • Tracking calculation in drug/placebo related compartment, corridor and total (entries,...

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RECORD-IT! Digital Video Recording Systems Video Tracking • RECORD-IT! Digital Video Recording Systems Ensure traceability ► Systems available for one to 8 cameras ► Record each camera independently as defined by the user ► Generates digital video files that can be processed with standard codecs in a Microsoft® Windows environment (no proprietary format restrictions) ► Independent video files can be generated on-the-fly ► Compatible with our SMART video tracking system, but not exclusive We offer several different options for external digital video recording for ensuring traceability and security...

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Built-in RECORD-IT! BASIC NEEDS Computer Dependency Digital Video Recording / Tracking simultaneous Process of the same Experiment Quality/Price Ratio SMART Built-In/External Solution Digital Video File specifications Image source camera Number & Productivity sMART V2-5, & smart Junior compatibility Other specific Features Video Tracking • RECORD-IT! Digital Video Recording Systems Panlab www.panlab.com iimrniHBiTs

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LimeLight Video Tracking Software Video Tracking • LimeLight Video Tracking Software key features Developed in close collaboration with behavioral neuroscientists ► Flexible and powerful video tracking system ► Ideal for: Open Field, Plus Maze, Zero Maze, Novel Object Recognition, Conditioned Place Preference parameters measured ► Distance travelled in each region (cm or %) ► Time spent in each region (sec or %) ► Crossings into each region ► Body length from nose to base tail (mm), together with stretch-attend bouts ► Pointing direction (orientation) ► Mean distance from center ► Latency to...

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