Endomicroscopy. More than meets the eye. New horizons in diagnostics and therapy. Endomicroscopy is an innovative and unique endoscopic imaging modality. It allows in vivo microscopy of the whole mucosal layer with cellular resolution during ongoing gastrointestinal endoscopy. This is achieved by a miniaturized confocal microscope, which is embedded into the distal tip of an otherwise normal endoscope. The endomicroscope can be placed at any area of interest within the intestine during the ongoing examination. The blue laser light of the endomicroscope interacts with contrast agents within the mucosa, which have to be applied topically or intraveniously. This results in endomicroscopic images from the surface down to the deepest parts of the mucosal layer. Histology. In vivo. PENTAX Europe GmbH LIFE CARE Julius-Vosseler-Straße 104 22527 Hamburg Germany Tel.: +49 40 / 5 61 92 - 0 Fax: +49 40 / 5 60 42 13 E-mail: [email protected] Endomicroscopy. A deep insight into the cellular structure of the mucosa. PENTAX U.K. Limited LIFE CARE Pentax House Heron Drive, Langley Slough SL3 8PN United Kingdom Tel.: +44 17 53 / 79 27 23 Fax: +44 17 53 / 79 27 94 E-mail: [email protected] PENTAX France S.A.S. LIFE CARE 112 quai de Bezons P. B. 204 95106 Argenteuil France Tel.: +33 1 / 30 25 75 75 Fax: +33 1 / 30 25 75 76 E-mail: [email protected] PENTAX Nederland B.V. LIFE CARE Lage Mosten 35 4822 NK Breda Netherlands Tel.: +31 76 / 5 31 30 31 Fax: +31 76 / 5 31 30 00 E-mail: [email protected] PENTAX Italia S.r.l. LIFE CARE Via Dione Cassio, 15 20138 Milano Italy Tel.: +039 / 02 50 99 58 1 Fax: +039 / 02 50 99 58 60 E-mail: [email protected] Left: Normal colonic mucosa showing regular crypt architecture and vascular pattern Right: Colonic adenoma with tubular crypt architecture and reduced amount of goblet cells HOYA Corporation PENTAX Life Care Division 1-1-110, Tsutsujigaoka Akishima-shi 196-0012 Tokyo Japan Tel.: +81 33 / 9 60 51 55 Fax: +81 35 / 3 92 67 24 LCM01/09/10/320116/02 S.I.M. - Sistemas Integrales de Medicina, S.A. LIFE CARE Sistema Solar 25 28830 San Fernando de Henares · Madrid Spain Tel.: +34 91 / 301 62 40 Fax: +34 91 / 751 31 15 E-mail: [email protected]

Endomicroscopy will make you question your present daily routine. There is more behind Endomicroscopy. Sanduleanu et al. proved for the rst time the ability of Endomicroscopy to differentiate colorectal lesions based on cellular, vascular and nuclear changes using ouresceine and acriavine as combined contrast agents (Clin Gastroenterol. Hepatol. 2010 Apr; 8(4):371-8). The endomicroscop- A whole new range of possibilities. ic visualization of nuclei enabled differentiation of low-grade from highgrade dysplasia with high accuracy (96.7%). The bright signals in the endomicroscopic image represent...