PEPperCHIP® Pan-AAV Capsid Protein Microarray Profile antibody responses against 15 AAV capsid proteins on the epitope level, in one single assay. Profile antibody responses against the most important wild type AAV capsid proteins with the PEPperCHIP® Pan-AAV Capsid Protein Microarray. The microarray contains the sequences of 15 different capsid proteins converted into over 5,000 overlapping peptides for high-resolution epitope data. Available with linear or cyclic constrained peptides for linear or conformational epitope mapping, the PEPperCHIP® Pan-AAV Capsid Protein Microarray can be used to analyze patient and animal sera as well as research and diagnostic anti-AAV antibodies on the epitope level. AAV capsid proteins antibody monitoring in patient sera before and after gene therapy · Identification of cross-reacting anti-AAV antibodies · Identification of pre-existing anti-AAV antibody responses in healthy individuals analysis of anti-AAV antibody responses in animal models · Validation of research or diagnostic antibodies against AAVs Control Antibody profiles Overlapping peptide library PEPperCHIP® Pan-AAV Capsid Protein Microarray Figure 1. Antibody fingerprinting workflow using the PEPperCHIP® Pan-AAV Capsid Protein Microarray. Fifteen different wild type AAV capsid proteins are converted into overlapping peptides and printed onto glass slides. Patient or animal serum is incubated on the microarray and antibodies present in the sample bind their corresponding epitopes on the microarray surface. The resulting response profiles can be compared across different samples to identify and monitor antibody reactivity against AAVs used in gene therapy research and development. PEPperPRINT GmbH

PRODUCT DETAILS Available Microarrays Organism Microarray content Sequence Compilation PEPperCHIP® Conformational Pan-AAV Capsid Protein Microarray PEPperCHIP® Linear Pan-AAV Capsid Protein Microarray Various adeno-associated virus Capsid proteins of the following AAVs: · AAV1 (protein ID NP_049542.1) · AAV2 (protein ID P03135) · AAV3b (protein ID O56139) · AAV4 (protein ID O41855) · AAV5 (protein ID Q9YIJ1) · AAV6 (protein ID O56137) · AAV7 (protein ID Q8JQG0) · AAV8 (protein ID Q8JQF8) · AAV9 (protein ID AAS99264.1) · AAVrh.10 (protein ID AAO88201.1) · AAVpo.1 (protein ID ACN42940.1) · AAV10...