PEPperCHIP® Peptide Microarrays for Cancer Research Analyze cancer frameshift and point mutations. Monitor tumor-specific antibody responses. Identify neoepitopes, in one single assay. Screen and characterize tumor or patient-specific antibody responses against tens and thousands of peptides in a single assay with PEPperCHIP® Peptide Micorarrays for Cancer Research. Browse our selection of PEPperCHIP® Standard Peptide Microarrays with pre-designed peptide libraries containing known human immuno-oncogenic antigens converted into overlapping peptides, learn more about our personalized PEPperCHIP® Cancer Neoepitope Microarrays, or design your own PEPperCHIP® Custom Peptide Microarrays with any tumor-specific peptide content of your choice. Immuno-oncogenic / Tumor antigen(s) Patient sera of therapeutic antibodies against tumor-associated or immuno-oncogenic antigens of immunogenic epitopes for immunotherapy, early disease detection, or the developent of cancer vaccines · Monitoring of patient-specific anti-tumor antibody responses · Discovery of prognostic cancer neoepitopes Healthy control Antibody profiles Overlapping peptides PEPperCHIP® Peptide Microarrays Antibody fingerprinting workflow for cancer research using PEPperCHIP® Peptide Microarrays. Immuno-oncogenic or patient-specific tumor antigens are converted into overlapping peptides and printed onto glass slides. Patient sera is incubated on the microarray and antibodies present in the sample bind their corresponding epitopes or neoepitopes on the microarray surface. The resulting response profiles can be compared across different samples to identify and monitor antibody reactivity against immuno-oncogenic tumor antigens for immunotherapy, cancer vaccine or IVD/CDx development. PEPperPRINT GmbH

PEPperCHIP® Standard Peptide Microarrays for Cancer Research details Antigen Microarray Epitope Microarray Antigen Microarray Microarray 21 melanoma antigens content (e.g. MAGE 1-4, MUC18, p53) as 4,125 overlapping linear peptides 3,653 linear B-cell epitopes of human oncoviruses, including 7 citrullinated peptides with corresponding arginine variants 22 tumor antigens (e.g. p53, NY-ESO-1, SOX-2) as 4,319 overlapping linear peptides Peptide lengths 15 amino acids with 13 3 amino acids to 20 amino 15 amino acids with 13 and overlaps amino acid overlap acids depending on epito- amino acid overlap...