ePTFE vascular prosthesis with B ioactive luminal coating with double mechanism of action 1 ) Antithrombogenic effect for advanced hemocompatibility Injured vessel Initiation phase Fibrinogen Cross-linked Fibrin Clot Propagation phase Clot formation PM FLOW Plus Heparin Inhibition of Thrombin Propagation phase Cross-linked Fibrin Clot Heparin binds to the antithrombin  III (AT III) thanks to its bioactive site causing its conformational change and its activation. The activated AT III then inactivates proteases involved in blood clotting, most notably thrombin and Faxtor Xa. A : The formation of a complex between AT III, thrombin, and heparin results in the inactivation of thrombin. B : The conformational change in AT III on heparin-binding lead to its inhibition effect on factor Xa. Prevention of thrombosis and blood clot formation R 2 ) educed neointimal hyperplasia Heparin molecule is known to reduce neotimal hyperplasia phenomenon (1). Thus PM FLOW Plus Heparin bioactive coating helps to prevent progressive perianastomotic stenosis development which could lead to late thrombosis. (1) ai WW, Heparin coating of small-caliber decellularized xenografts reduces macrophage infiltration and intimal hyperplasia, Artif Organs. C 2009 Jun;33(6):448-55.

Peripheral Bypass Heparin coating Acute Thromboresistance In-vivo comparative study on pig (4) (highly thrombogenic animal model). Explanted vascular grafts after challenging 3 hours implantation at the level of carotid arteries : Control ePTFE PM FLOW Plus Heparin (left carotid artery) (right carotid artery) Anastomosis area : No thrombus formation observed on the PM FLOW Plus Heparin contrary to control ePTFE Medial area : No thrombus formation observed on the PM Flow Plus Heparin contrary to control ePTFE L ong-lasting antithrombogenic activity Heparin molecules are strongly attached to the...

Peripheral Bypass ePTFE vascular prosthesis with Heparin coating Thin Wall References Wall thickness Wall thickness Thin Wall with helical reinforcement This device is CE marked.

Peripheral vascular reconstructions Peripheral Bypass ePTFE vascular prosthesis with Heparin coating Heparin B ioactive luminal coating with double mechanism of action • Antithrombogenic effect • Reduced neointimal hyperplasia L ong-lasting antithrombogenic activity Full range of sizes and diameters with and without helical reinforcement