High precision Temperature control solutions for the Pharmaceutical industry and Biotechnology
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5 High precision Temperature control solutions for the Pharmaceutical industry and Biotechnology

Temperature control solutions for the Pharmaceutical industry Huber offers a wide range of temperature control systems and associated accessories. The perfect unit for any application can be found within the range and help is always at hand to guide users to the right product for their application. This assistance is in the form of engineering expertise, well qualified and experienced partners and our wide range of Case Studies freely available on our web site. Our portfolio can be broadly split into three ranges: Unistats (hydraulically sealed thermostats), Open Bath Thermostats and...

ǡ Process thermostats Unistats are designed to control temperature in a wide variety of applications across all industries. They are used extensively in many departments and applications in the Pharmaceutical industry from small scale research to large scale production over a temperature range of -125 °C to 425 °C. Their ability to rapidly change the temperature of the circulating heat transfer fluid (HTF) and the advanced self-tuning PID controller provides the application with extremely tight and responsive temperature control. This can be seen in the Case Study collection on the Huber...

High precision temperature control in Research, Development Research & Development Huber units provide stable and predictable temperature control. This performance removes an unpredictable variant from the research. The rapid response of Unistats make them a common feature to keep the increased energy in larger reactions under tight temperature control. Analytical laboratory These labs commonly use simple chillers (OLÉ range) to remove heat from sensitive Analytical instruments.

Can be “low” or “high” volume batches. Unichillers fitted with heaters provide economic and reliable temperature control on Bio Reactors from Bench scale 1-litre fermenters to 3,000-litre Production scale Bio Reactors. Formulation Typically, bench-top open bath systems and chillers are used in various applications. Continuous flow Unistats and open bath units are used to reliably and accurately control the temperature of the reaction zones within the reactor. Quality control Procedure intended to ensure that raw ingredients, purchased compounds etc. a finished product under development or a...

Application examples  Glass reactors Jacketed glass reactors are a common tool. The ability to control the temperature of the reaction mass depends on the speed at which the jacket’s temperature can be changed to transfer thermal energy through the glass wall. The speed of transfer depends on the thermal qualities and design of the reactor and the Delta-T between the jacket and reaction mass. Glass reactors are inherently sensitive to pressure (typically the maximum permissible jacket pressure is 0.5 bar) and thermal shock (caused by the difference in temperature between the jacket and the...

Glass lined reactors Stainless steel reactors The metal component of the reactor will have a different expansion coefficient to the glass lining. To protect against stripping the glass by heating or cooling too quickly, the ramp rate can be set and controlled to either change the temperature of the jacket at a rate that does not endanger the glass lining or to be programmed in steps so that a “dwell” time allows the glass and metal to settle at the same temperature before the next change in temperature. These reactors are robust and are typically not subject to damage from either jacket...

Bioreactors Often, bioreactors can only use water or water/glycol as an HTF. After a process, the bioreactors need to be cleaned and sterilised "Cleaned In Place" (CIP) and "Sterilised in Place" (SIP). These routines are carried out at temperatures up to 120 °C using steam (The Huber Unichiller T-H temperature range can be extended to +120 °C). Before this can take place, the bioreactor's jacket must be drained of the water/glycol. Using a series of valves the reactor jacket can be drained into a holding tank and on completion of SIP. The system can be refilled by starting the chiller's...

 Controlled Rate Freeze & Thaw Some preparations need to be frozen at a predefined rate and then thawed at a predefined rate. The built-in ”Program“ feature in the Pilot ONE allows the creation of multiple programs that can be either stored in the Pilot ONE memory or onto a Thumb drive via the USB interface. The creation of a program is highly flexible yet extremely simple to realise thanks to the simple graphic display which clearly shows each step in the program as it is created and when it is completed. The frozen blocks of medical preparation can be thawed out in a special bath. These...

Application examples Rheometers, Viscometers To provide accurate and constant temperature control of a sample while under test, the Ministat or a unit from the “K” series are used. Compact, flexible and providing thermal stability to 0.02 K, these units can be ideal for controlling viscometer samples. Diverse analytical laboratory equipment such as X-ray diffractometers, mass spectrometer, etc. produce heat which has to be removed effectively. Huber chillers as source of external cooling with its compact design and small foot print will save precious space in labs.  Milling machines The...

Applications and units Application Open Baths Climate chamber Heat transfer station Immersion Cooler Cooling of sealing of drying oven Cold plates Decentralization of centralized cooling system Defined thawing of a medicinal preparation Distillation devices, short path distillation Filter, tangential flow filter, filter dryer Freeze dryers, spray dryers Freeze thawer Fume hood Liquid extraction columns Milling machine Particle sizer Mixing vessel Reactor, biology Reactor, cascade Reactor, glass Reactor, continuous flow Reactor, stainless steel / pressure Reactor, pallet Reactor,...