ADS 610
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Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 Staggered or simultaneous stirrer start, manual or automated operation is offered by the advanced ADS-PTWS610 System. It includes an Ismatec Multi Channel Peristaltic Pump and a SA500 UV/VIS Diode Array Spectrophotometer or a T70 UV/VIS split beam UV/VIS Photometer with 8-cell changer. The fully automated closed loop Tablet Dissolution Testing System is controlled by the WinDiss32 Software Suite which is fully 21CFR Part 11 compliant. The PTWS 610 6+2-station Dissolution Bath is equipped with the EPE Auto-Sampling Manifold and a manual Tablet Drop Magazine. The added advantage of the EPE option is that the sampling probes are only in the dissolution medium when sampling is required. The EPE is raised out of the bath after the sampling sequence is complete. This fulfils the other school of thought that sampling probes should only be in the solution for a minimum period so as to avoid unnecessary solution perturbation. Each sampling tube may be fitted with 5 or 10 micron in-line filters so as to avoid the passage of insoluble excipients into the measurement cells inside the spectrophotometer. Using the Tablet Drop Magazine all 6-8 samples are dropped at the same time into the Dissolution Vessels for simultaneous sampling and measurement. Teflon tubing is connecting the Dissolution Vessels via an 8 channel Peristaltic Pump (IPC 8) to the Photometer with its built-in 8 cuvette changer. All instruments are controlled by the WinDiss32 Software which has to be installed to a suitable PC. As with nearly all sampling systems re-usable in-line filters are attached to the sampling tubes which are only placed in the dissolution vessel while sampling whenever the EPE Sampling System is used. Sampling position, distance and dimensions are according to the USP directive which states that the sampling point must be exactly half way between the dissolution medium surface and the top of the stirring tool (Paddle, Basket or TD cylinder). At +49 6182 9532-600 +49 6182 9532-650 email@pharma-test.de www.pharma-test.com PHARMA TEST AG Siemensstrasse 5 D-63512 Hainburg (GER)

Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 the appropriate pre-programmed time the EPE will drive down into sampling position, the pump will be switched on and the sample tubing lines to the cuvettes are filled. The pump will be stopped and the spectra measured are transferred from the spectrophotometer to the WinDiss32 Software for further processing. Also stirring speed, bath and media temperature (optional), sampling and measuring time are logged. The PTWS 610 can also be fitted with an optional online temperature monitoring device ITM connected to the EPE...

Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 On-line Systems Using an automated Dissolution System is offering a good number of advantages, such user free sampling, on-line measurement of drug absorbance, accurate sampling timing, precise sampling positioning both either using an inside media sampling probe (insitu) or a removing EPE sampling system which remains only inside the media as long as sampling takes place. Also data correction, using the on-line Standard and/or Blank Media and automated result calculation will save time and offer highest quality data...

Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 The Photometer We offer different Spectrophotometer Drivers which may be incorporated into the ADSPTWS610 Auto Dissolution Test System. Depending on the application the system should be used for the user may select between single beam, split-beam and double beam Photometers or Diode Array Detectors. The use of a single, split or double spectrophotometer is possible if only single or multiple wavelength tests with now timing problem have to be performed. As soon as measuring speed or spectra scanning should be done we...

Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 high performance characteristics flexibility user friendly operation. Reproducible measurements… UV-Visible Spectroscopy is a universally accepted, well documented technology with many applications. The technique is extensively used for the analysis of foods, drugs, agricultural products and is widely used in the medical care, public health, environmental protection, life sciences industries and many other organic and biochemical applications. The T70 series of UV-Visible Spectrophotometer offer excellent performance, high...

Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 Data collection rate: The user can enter multiple data collection times during the entire dissolution run thus allowing more data points when active dissolves quickly and less towards the end of the profile. FDA 21 CFR part 11 Compliance The WinDiss32 Administration allows the system administrator to enter details of users to access the system. The user Logon name, full name and password are configured for each user with Group or individual access rights. Individual access to the system is by a unique user name and password...

Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 WinDiss32 provides the user with total management of the signing process, from start to finish. This includes configuring the number of signing levels, the Users for each level, Signer Activity and Meaning. PHARMA TEST AG Siemensstrasse 5 D-63512 Hainburg (GER)

Fully Automated Tablet Dissolution Testing System- Type ADS-PTWS610 Signing and Reporting Signed Records Once data is acquired in a Group with signing rights, any report generated will show the signing status for all pages of the record shown on the report. Product Name Method Group Method Group John Brown TEST Group Name Station Name Date - Time Quality Control Dtsso lution. Time (hh:mm:ss) Technician Tested by John Brown 05 10 2004 09:50 Analyst Sign Off Signing Level Supervisor Requires Signing. Signing Level Qualified Person" Requires Signing. PHARMA TEST AG Siemensstrasse 5 D-63512...