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Fully Automated Tablet Dissolution Testing System- Type ADS-DT70 Simultaneous stirrer start, manual or automated operation is offered by the advanced ADS DT70 System. It includes a Ismatec Multi Channel Peristaltic Pump and a Pharma Test T70 UV/VIS Spit-Beam Spectrophotometer or a any other suitable UV/VIS Photometer with 8-cell changer. The fully automated closed loop Tablet Dissolution Testing System is controlled by the WinDiss32 Software Suite which is fully 21CFR Part 11 compliant. The DT70 4+3-station Low-Head Dissolution Bath is equipped with insitu Sampling probes. The Drive Head automatically centres and closes the dissolution vessels when in operation position. Each sampling tube may be fitted with 5 or 10 micron in-line filters so as to avoid the passage of insoluble excipients into the measurement cells inside the spectrophotometer. Drop all 6-8 samples into the Dissolution Vessels for simultaneous sampling and measurement. Teflon tubing is connecting the Dissolution Vessels via an 8 channel Peristaltic Pump (IPC 8) to the Photometer with its built-in 8 cuvette changer. All instruments are controlled by the WinDiss32 Software which has to be installed to a suitable PC operating under Windows™ XP operating software. As with nearly all sampling systems re-usable in-line filters are attached to the sampling tubes which are placed in the dissolution vessel during the entire test, distance and dimensions are according to the USP directive which states that the sampling point must be exactly half way between the dissolution medium surface and the top of the stirring tool (Paddle, Basket or TD cylinder). At the appropriate pre-programmed time the pump will be PHARMA TEST AG Siemensstrasse 5 D-63512 Hainburg (GER)

Fully Automated Tablet Dissolution Testing System- Type ADS-DT70 switched on and the sample tubing lines to the cuvettes are filled. The pump will be stopped and the spectra measured are transferred from the spectrophotometer to the WinDiss32 Software for further processing. Also stirring speed, bath and media temperature (optional), sampling and measuring time are logged. As the DT70s fitted with 7 vessels, then cuvette 7can be filled with a fresh Reference Standard or it is connected to vessel 7 which may hold Blank Media. This can be measured each time prior to the measurement sequence....

Fully Automated Tablet Dissolution Testing System - Type ADS DT70 On-line Systems Using an automated Dissolution System is offering a good number of advantages, such user free sampling, on-line measurement of drug absorbance, accurate sampling timing, precise sampling positioning using an inside media sampling probe (insitu). Also data correction, using the on-line Standard and/or Blank Media and automated result calculation will save time and offer highest quality data presentation. This popular configuration is elaborate, but allows real time calculation of results using the new fully 21...

Fully Automated Tablet Dissolution Testing System - Type ADS DT70 The use of a single, split or double beam spectrophotometer is suitable if only single or multiple wavelength tests with now timing problem have to be performed. As soon as measuring speed or spectra scanning should be done we recommend the use of a PDA Diode Array UV/VIS Spectrophotometer. Any of the possible Spectrophotometer Types which can be included needs to be equipped with a 6- to 8-cell changer. The cell compartment should have enough space to connect the required Tubing and allow free movement of the cell changer...

Fully Automated Tablet Dissolution Testing System - Type ADS DT70 password protection and administration, electronic signature, report generator etc. It offers single ob multi-component analysis. The ADS System components are controlled and integrated into WinDiss32 Dissolution Data management software which is used by the worlds largest Pharmaceutical companies. Driver Linkage with Unique Solution Path Technology • WinDiss32 Supports a wide range of Baths, Auto samplers, Fraction Collectors, Pumps, and other Detectors It uses a Unique Solution Path Technology Configuration for different...

Fully Automated Tablet Dissolution Testing System - Type ADS DT70 Configurable Centralised Security The Global Settings allow the administrator to set limits to prevent unauthorised access to the data station, Password expiry, Log Off Times etc for each Access Level. These activities can be performed remotely from any WinDiss32 networked workstation. WinDiss32 provides the user with total management of the signing process, from start to finish. This includes configuring the number of signing levels, the Users for each level, Signer Activity and Meaning. PHARMA TEST AG Siemensstrasse 5...

Fully Automated Tablet Dissolution Testing System - Type Signing and Reporting Signed Records Once data is acquired in a Group with signing rights, any report generated will show the signing status for all pages of the record shown on the report. Product Name Method Group Method Group Join Broun TEST Group Name Station Name Date - Time Quality Control Dtsso lution. Time (hh:mm:ss) Technician Tested by John Brown 05 10 2004 09:50 Analyst Sign Off Signing Level Supervisor Requires Signing. Signing Level Qualified Person" Requires Signing. PHARMA TEST AG Siemensstrasse 5 D-63512 Hainburg (GER)

Fully Automated Tablet Dissolution Testing System - Type ADS DT70 Dynamic Report Editor The WinDiss32 report organizer allows users to produce customized reports with the right information by selecting from a combination of objects such as Method Header, Data Tables, Method Parameters, Graphs and the Company Logo. These details may include any parameter measured during the test such as Bath Temperature, Paddle Speed, Time Intervals as well as Absorbance, Concentration and % Dissolved. Any number of pages can be selected with automatic page numbering. Standard Report Format Graphics Printer...

Fully Automated Tablet Dissolution Testing System - Type ADS DT70 User Queryable Audit Trail WinDiss32 Audit Trail lists all user activity that creates, deletes or modifies; i.e., from logging on and off to editing of method and data records. This Audit Trail can be queried to limit the volume of information from a search and the results from any search can be printed. Networking Our networked system provides a central relational database that contains all data (methods and data records) from all WinDiss32 workstations. Details are accessible from any station linked to the networked...