IDS 1000
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Catalog excerpts

IDS 1000 - 1

In-Situ Tablet Dissolution Testing - Type IDS 1000 What is IDS 1000 In-Situ Dissolution? IDS or In situ Dissolution System is about the application of direct measurement technology to Dissolution Testing. Traditionally, dissolution testing has been carried out on solid dosage forms using a standard dissolution tester. Samples of the dissolving active within the dosage form are taken for estimation from the dissolution tester either manually, or using more automated means such as a pump which has been connected to a suitable measurement device, usually a UV Spectrophotometer. Using IDS 1000, not only can the whole process of sample measurement be automated, but can also be self contained, such that there is no need for samples to be pumped out of the dissolution vessels to external measurement facilities such as a spectrometer, because all that is needed for the measurements to be made is contained within the confines of the instrument itself. How does it work? In the first instance the introduction of tablets or other dosage forms is as with a conventional dissolution instrument using a synchronous tablet drop magazine. The instrument is started according to the WinDiss32 Dissolution Software control, but the sampling sequences have been replaced by direct measurement technology within the dissolution vessel itself, with each measurement cycle accomplished in seconds rather than minutes. PHARMA TEST AG Siemensstrasse 5 D-63512 Hainburg (GER)

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IDS 1000 - 2

In-Situ Tablet Dissolution Testing - Type IDS 1000 The in situ measurement is carried out using fibre optic probes which are located in the shafts of the dissolution tools, i.e., a paddle or a basket (Apparatus 2 or 1). The fibre optic probe can be removed from the shaft so that various path length inserts can be employed for different active concentrations and extinction coefficient ranges. The fibre optic probe can then be simply reinserted into the tool shaft and the next analysis started. Why is it different? This system is different for many reasons and brings a really new dimension to...

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IDS 1000 - 3

The IDS 1000 offers both. All test vessels are placed in a 4 + 4 line-up so that it is easy to remove spent samples and refill with medium. The clear-view Plexiglas water bath sits on vibration absorbing feet as does the built-in circulation pump. There are external temperature probes to better control both bath and medium temperature. The special design, in which the pump and heating system (as well as the mains electronic boards) are accessible without having to move the instrument, coupled with the fact that the water bath is placed on vibration absorbers virtually eliminates any...

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IDS 1000 - 4

Measurements made with hollow shaft technology > 316 Stainless steel fabrication throughout > Paddles or baskets just screw into mono shaft > Paddle "windows” allow good flow through of medium System set up to work with almost all USP tools > Choose USP 1 or USP 2 as well as USP 5 > Special tools for trans-dermal patches and creams > Easy tool change over > Qualify the 25mm position for paddles and all other tools are automatically in correct working position. Synchronous tablet drop with auto-magazine > Program controlled tablet drop for all vessels while stirrers don’t move > Tablet...

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IDS 1000 - 5

• Empty the water bath completely via the center drain tap • Automated Tablet Drop magazine with incorporated vessel covers to stop media evaporation • Clearly visible LCD screen shows actual operational status, "traffic light” display to highlight any errors. • Visible and acoustic information informs the user of measurement sequences which take place in the instrument. • Fully automated self check and re-adjustment of stirrer drive and bath thermostat as soon as any change has been detected. • Programmable heater start up and shut down time. • Vibration free water bath assembly, placed on...

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IDS 1000 - 6

> Temperature Range: > Test Vessels: > Stirrers: > Tablet Introduction: > Sample Analysis: > Dip Probes: > Reference Cell: > Calibration Setup: > Control: > Software: > Validation: 25.0° C - 45° C, ± 0.2° C 8 round bottomed USP 1 litre glass vessels, individual numerical coding, 1 vessel for standard and 1 for medium (blank) 8 off 316 stainless steel mono-shafts with 316 stainless steel blades screwed into the mono-shafts 1 automated magazine which drops 1 sample automatically at start of a run into the dissolution vessel during which time the stirrers are stopped UV Diode Array...

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IDS 1000 - 7

What are the key Spectrometer USP’s? > SST, System Suitability Test prior to the start of an analytical sequence. > Easy access to lamp and power supply - without having to physically move the bath or the housing of the complete test equipment. Supports service and maintenance in an efficient way. > Fast acquisition of all 9 channels in less than 20 seconds > Real sequential dual beam operation with reference and intensity compensation > Much higher response time, up to 50 times faster compared to existing systems > A special highlight is the possibility of high speed kinetic measurements...

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IDS 1000 - 8

Diode Array Detector: Spectral range: Spectral resolution: Optical grating: Baseline noise specification: Wavelength accuracy: Temperature Drift: Scattered light: Light sources: Light source: Lifetime: Data Integration: TIDAS Detector element with 1024 diodes 190 nm - 610 nm 0.8nm per pixel 248 L/mm Extremely low at < 50 AU peak to peak without smoothing Long term stability < 0.1nm Repetitive Accuracy is < 0.1 nm < 0.005nm / °C < 0.1% @ 340nm (D2 lamp) Integrated D2 Built in light source with light transfer using fibre guides D2 lamp has a life of approx. 1500 hours Data integration time...

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IDS 1000 - 9

In-Situ Tablet Dissolution Testing - Type IDS 1000 Configurable Centralised Security The Global Settings allow the administrator to set limits to prevent unauthorised access to the data station, Password expiry, Log Off Times etc for each access level. These activities can be performed remotely from any WinDiss32 networked workstation. WinDiss32 provides the user with total management of the signing process, from start to finish. This includes configuring the number of signing levels, the Users for each level, Signer Activity and Meaning. Signing and Reporting Signed Records Once data is...

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