WinDiss ARGUS
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Dissolution Software Program - WinDiss32-V3 WinDiss32-V3 Automated Tablet Dissolution Testing and HPLC Analysis using the Agilent Chemstation™ Software - System Description and Requirements - …unique automated solution for HPLC Dissolution Analysis PHARMA TEST AG Siemensstrasse 5 D-63512 Hainburg (GER)

Dissolution Software Program - WinDiss32-V3

Dissolution Software Program - WinDiss32-V3 1 General Information The WinDiss32-V3 HPLC option provides an analytical system for customers to configure analysis for Dissolution testing utilising Agilent Chemstation™ and 1100 LC system. WinDiss32-V3 control Dissolution Baths, Pumps and collects samples in the Autosampler ASP2000 Workstation. These samples can be further Diluted, Mixed and injected into the Agilent 1100 LC Peak data are acquired from Chemstation after each injection and processing and WinDiss32-V3 calculates and plots the Dissolution profile in real time. Data is stored using...

2 System Requirements The following represents a base system only. Customers should apply for a quotation at the time of ordering or for budgeting purposes. WinDiss32-V3 Software Program for HPLC Sample Processing -Collection, Dilution, Mixing, Injection and HPLC measurement. Systems Cables for Pump and MSV Integrator and Auto-Zero Cable to RS8/IO ASP 2000 Auto Sampling Workstation ASP 2000 HPLC Injection Valve with Control MSV2X800 Media Switcher (closed loop sampling prior to dispensing (2nd. valve block and 16 channel pump if media replacement is required) RS8/PC Cable to ASP 2000 IPC 8...

4 Driver Linkage with unique solution path technology > Support a wide range of Baths, Pumps and ASP2000 Analytical Processing Workstation > Unique Solution Path Technology > Configuration for different analysis requires no additional configuration. > Support for Closed and Open Loop Dissolution systems. > Collect and store Samples in ASP2000 Analytical Processing Workstation to perform online Dilution, Mixing and Injection into Chemstation™ HPLC. > Other options include Offline sample preparation of Liquid Finished Products followed by HPLC measurement. The WinDiss32-V3 system can...

Dissolution Software Program - WinDiss32-V3 A typical system configuration is shown below and consists of a Bath, Pump, the ASP 2000 AutoSampler Workstation and Chemstation™ CDS. The maximum or available functionality of each instrument is utilised. For example, Temperatures for Baths with Vessel Temperature probes will show all temperatures for each Vessel while those with only one bath probe will only display a single temperature. Icalis ASP2000 HPLC Injection Valve ASP01023 Agilent ChemStation Cavro XL3000 8 Syringe Diluter C Schematic for an HPLC System, designed using WinDiss32-V3...

Dissolution Software Program - WinDiss32-V3 Once the workstation has been installed, a search for all HPLC Systems on the Workstation selected will occur. At the start of the analysis, the WinDiss32-V3 method will show all HPLC Systems installed on the workstation and will establish communications with the Chemstation HPLC System selected. A list of all methods on the HPLC System selected will appear. Once a method is selected for the analysis, certain parameters from the method, i.e., the processing time is acquired from the Chemstation method and used as part of the timing sequence in the...

Dissolution Software Program - WinDiss32-V3 This simple but effective approach makes working with WinDiss32-V3 and Chemstation seamless, thus simplifying the whole operation. 7 Flexible Methodology In today’s world of diverse dissolution applications, WinDiss32-V3 provides the most dynamically configured methodology to suit most customers’ requirements. From a simple HPLC Dissolution System to systems with pH and Media change, Cell Grouping for comparative dissolution testing to running multiple dissimilar tests on one PC, the WinDiss32-V3 has the functionality. 8 Multiple Standards with...

Dissolution Software Program - WinDiss32-V3 9 Acquisition of Bath Parameters Temperature and Speed are acquired from the Bath throughout the analysis. These can be acquired more frequently than the Sampling or Time Interval. 10 Comparison or Different Testing Conditions WinDiss32-V3 has many research features which are unique to our dissolution system configurations. Users can for example group their Samples, 2 Groups of 3 Samples or 3 Groups of 2 Samples etc for comparative Dissolution Testing, for method development or comparing stability conditions where each Group can be a different...

Dissolution Software Program - WinDiss32-V3 11 HPLC Analysis with pH Change by Media Addition and or Removal WinDiss32-V3 provides the most advanced functionality for changing the pH throughout the experiment. Systems for Discrete or Gradient Media Addition can be configured with Media removal to allow for a single or multiple Media Change during the analysis, results calculated and displayed in real time. For a full Media change, the user will be prompted when a full change is occurring and the experimental timer can be configured to halt until the change has occurred. This will allow you...

Dissolution Software Program - WinDiss32-V3 12 System Control and Real Time Display of Results The ASP 2000 Auto Sampler Workstation allows simultaneous operations for Sampling, Dilution, and Injection into a Chemstation LC system. After each injection, Chemstation perform the processing and the integrated values or results are acquired from the Chemstation System. The dissolution profile is updated and displayed numerically and graphically in real time on WinDiss32-V3 workstations. There is no need for any manual intervention once this system has started. Using a special Deferred Data...

Dissolution Software Program - WinDiss32-V3 13 Display of Compliance Table and Ranges Graphically During the analysis or after the test has completed, the compliance table indicating whether the test has passed or failed can be displayed graphically or numerically. This is a very important tool for Quality Control and for Stability studies. Specification Compliance Table – Multiple Specifications can be configured for different pharmacopoeia requirements Graphical display of Specification Compliance PHARMA TEST AG Siemensstrasse 5 D-63512 Hainburg (GER)