EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND
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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 1

EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND DRESSINGS IN TREATMENT OF CHILDREN WITH LOCAL BURNS Moscow Scientific Institute of Pediatrics and Children Surgery Moscow Children Hospital Named by G.N.Speransky Moscow Russia

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 2

Purpose of work: To assess following Pharmaplast Products on Children of the first 3 years of life, who were mostly injured with hot liquid as a thermal agent. Vilowond POVI Gauze (Silkofix POVI) • During the period from September 5 till December 15, 2012, the Thermal Injury Clinic of the Federal State Budgetary Institution Moscow Research Institute of Paediatrics and Paediatric Surgery of the Ministry of Health of Russia used Pharmaplast S.A.E (Egypt) dressings to treat 40 children with thermal injuries. The observed patients were divided into 4 groups (of 10 persons) according to the...

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 3

• The first group of patients was treated with Pharma-Jelly Net Ag (Fibrotul Ag) dressing which is a wound lipidocolloid bactericide sterile non-adhesive polymer network-based dressing with Ag ions. Composition: hydrocolloid particles (carboxymethyl cellulose), soft paraffin, Ag (HeiQ AGS-20), cohesive polymers, polyether network. HeiQ AGS-20 is a composite with Ag nanoparticles which are included into the dressing matrix and are a source of Ag ions to inhibit bacteria and fungi growth. Carboxymethyl cellulose particles absorb the exudates and turn into a cohesive gel with soft paraffin...

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 4

• The second group included 10 burned patients who received topical treatment with Pharmacoll Ag (Fibrocold Ag) dressing, which is a bactericide hydrocolloid sterile adhesive polymer-based dressing with Ag ions. Based on the polymer semi-permeable polyurethane film with a planimetric net covered with an adhesive matrix containing hydrocolloid particles (of carboxymethyl cellulose) and Zeomic particles (antibacterial Ag ion containing zeolite) impregnated through the entire dressing surface. Zeomic is an antibacterial zeolite consisting of composite structures containing Ag ions in silicon...

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 5

• The third group included 10 children whose burn wounds were treated with a hydrogel bactericide non-adhesive polymer-based dressing Pharmagel Ag (Silkofix Gel Ag). Its properties: bactericide, contains Ag ions, has a mild cooling effect and high absorptive capacity, transparent, impermeable for bacteria; its micromesh base provides air and moisture exchange; it is hypoallergic. It is based on a polymer polyurethane film covered with Ag ions containing hydrogel. Indications for use: 1. Topical burn wound (thermal, chemical, induced by electrical injury) of the I-II degree. 2. Dermal...

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 6

• 10 patients of the fourth group received topical conservative treatment with Vilowond POVI (Silkofix POVI). It is a povidone-iodine ointment, fabric net-based dressing. Its properties are as follows: bactericide, atraumatic and airproof. Indications for use: 1. Topical burn wounds (thermal, chemical, induced by electrical injury) of the I-II degree. 2. Infected wounds. 3. Granulating long non-healing wounds. 4. Burn wounds complicated with a herpetic infection. 5. Infected postoperative wounds. 6. Donor wounds. 7. Wounds after graft edge lysis 8. Pressure ulcers. • The efficacy of each...

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 7

Table 1. Patient grouping as to their age and type of a thermal agent Study characteristics Vilowond POVI Thermal Agent: Number, person As it comes from Table 1, the dressings were used in children of the first 3 years of life, who were mostly injured with hot liquid as a thermal agent. www.pharmaplast-online.com

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 8

Table 2. Patient grouping as to clinical characteristics of the burn wound process. Clinical characteristics of the wound process Wound area, % body surface area Wound epitalization 8(6;0) period, days Vilowond POVI Dermal autograft 7 (6;7) acceptance period, days Number of dressings 2 (2;3) No Side effects Bleeding sickness No when dressings are changed

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 9

Treatment of local superficial burns with PharmaJelly Net Silver & Pharmacoll Ag

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 10

Treatment of local superficial burns with Pharmagel Ag

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 11

Application of PharmaJelly Net Ag after grafting

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 12

Application of Vilowond POVI after plastic by local fabrics

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 13

Treatment of granulated wounds with Pharmacoll Ag

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 14

Treatment of granulated wounds with Pharmacoll Ag

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 15

The laboratory tests of wound process meant monitoring of the microbial landscape of burn wounds at the stages of their healing (Table 3). Table 3. Characteristics of the microbial landscape of burn wounds treated with modern dressings. Microbial landscape PharmaJelly Net Ag Before After Pure culture Mixed flora No growth Dressing Pharmacoll Ag Pharmagel Ag Before After Before After + + + + Vilowond POVI Before After + + The table data illustrate the antimicrobial activity of the tested dressings.

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 16

•The following recommendations for use of these dressings can come from the analysis of the use of the medical products in the topical conservative treatment of children with burn wounds. •Recommendations for the use of the PharmaJelly Net Ag, Pharmacoll Ag, Pharmagel Ag, Vilowond POVI dressings: 1. Any of the above listed dressings can be used as monotherapy: - for I-II degree partial-thickness burns - PharmaJelly Net Ag; - for II-III degree skin burns which are so-called mosaic burns - Pharmacoll Ag, Pharmagel Ag. 2. For long non-healing granulating wounds of less than 1% body surface...

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 17

During the research we calculated the cost of the topical treatment for one patient with topical burns of up to 10% of the body surface with use of two dressings PharmaJelly Net Ag and Pharmacoll Ag. The data are presented in Tables 4 and 5. • Table 4. Estimation of the cost of treatment for one patient with PharmaJelly Net Ag The cost of one PharmaJelly Net Ag dressing (15x15 cm) – 170 roubles 00 kopecks Percent Body Surface Area Number of PharmaJelly Net Ag Consumption Affected by Burns Dressings Material, pcs Dressing Total Cost of Topical Treatment of 1 patient, roubles Dermal autograft...

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EXPERIENCE OF USING SILVER &IODINE CONTAINING WOUND - 18

Table 5. Estimation of the cost of treatment for one patient with Pharmacoll AgThe cost of one Pharmacoll Ag dressing (15x15 cm) – 240 roubles 00 kopecks Percent Body Surface Area Number of Dressings with Consumption Affected by Burns Pharmacoll Ag Material, pcs Dressing Total Cost of Treatment of 1 roubles Topical patient,

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